|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed that children who were heterozygous or homozygous for both the CD14/-159T and TLR2/-16934A alleles had a 4-fold lower risk for asthma than children who were carriers of the T allele of CD14 but non-carriers of the A allele of TLR2, and an almost 3-fold lower risk for asthma when compared to all other groups.
|
31403268 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these data implicated that ABCA1 suppressed PDGF-induced proliferation, migration, and contraction in rat ASMCs at least partly through TLR2/NF-κB/NFATc1 signaling, which might offer hope for the future treatment of airway remodeling in asthma.
|
29775222 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Short-term exposure to A. fumigatus could down-regulate the expression of GCR, aggravate airway hyper-responsiveness and increase the level of TLR2 in rats with asthma.
|
28696809 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HE staining showed that the infiltration degree of inflammatory cells in perivascular tissues in TLR2-/- asthma group was reduced compared with that in C57BL/6 asthma group.
|
29863259 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combined results show that rs3804099 in TLR2 and rs4986791 in TLR4 were significantly associated with asthma risk.
|
28858111 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum IP-10 levels showed a significant negative correlation with age (p=0.009), TLR2 (p=0.05) and spirometric indices (p=0.002) in all asthmatics and a significant positive correlation with parameters of asthma attack severity (p=0.03) in acute asthma group.
|
27955890 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With respect to the TLR2 rs4696480 polymorphism, significant association was detected between asthma susceptibility and TLR2 rs4696480 polymorphism under dominant model (OR = 2.455, 95% CI = 1.235-4.88, P = .01) and codominant 3 model (OR = 2.776, 95% CI = 1.199-6.427, = 0.017).
|
28514297 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Asthmatics had significantly lower circulating HPC expressing TLR-2 and TLR-9 with a similar trend for TLR-4.
|
28252235 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
B7-H3 participates in the development of Asthma by augmentation of the inflammatory response independent of TLR2 pathway.
|
28094276 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chlamydia pneumoniae induces interleukin-12 responses in peripheral blood mononuclear cells in asthma and the role of toll like receptor 2 versus 4: a pilot study.
|
28035483 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, recent results indicate that the TLR-2 → NLRP3 → caspase-1 → IL-18 axis is critical to H. pylori-specific immune regulation conferring protection against allergen-induced asthma and inflammatory bowel disease in murine models.
|
27460807 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Wherease some previous studies indicated TLRs and their polymorphisms might have some role in asthma incidence and features, our data demonstrated that TLR2 Arg753Gln and TLR4 Asp299Gly gene variants were not risk factors for asthma or its features in Iranian patients.
|
25530138 |
2015 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR4 and TLR2 were reduced in total PBMC from asthmatics in comparison to PBMC from controls.
|
25722071 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that polymorphism of the TLR2 subfamily may be associated with prevalence of post-bronchiolitic asthma and/or atopy.
|
24445834 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of toll-like receptor (TLR) 2 subfamily genes, including genes encoding TLR1, TLR2, TLR6 and TLR10, have been connected to allergy and asthma.
|
24112285 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study demonstrates a lack of association of TLR2 and TLR4 polymorphisms with asthma and allergic rhinitis but suggests significant association between these genetic variants and the disease severity.
|
22402138 |
2012 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sputum TLR2 mRNA expression was up-regulated in both acute and stable asthma compared with healthy controls and decreased 4-6 weeks after acute exacerbation.
|
21129050 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interaction between ITGB3 SNPs and TLR2/+596, which was previously shown to be associated with asthma, was studied.
|
21570717 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, TLR2 expression at the protein and mRNA levels was upregulated in cord blood basophils from neonates born to mothers with asthma following stimulation with PGN but not Df.
|
21438704 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR2–16934A>T polymorphism could be a genetic predictor of AD severity, the coexistence of asthma or atopic conjunctivitis as well as a family history of atopic diseases, especially in subjects having higher TS IgE.
|
21134221 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Twenty-four single nucleotide polymorphisms (SNPs) in CD14, Toll-like receptor 4 (TLR4), TLR2, MD2 and MyD88 were genotyped in 408 agricultural workers with spirometry and questionnaire data on asthma symptoms available.
|
21389010 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased Toll-like receptor 2 (TLR2) expression has been reported in patients with chronic obstructive pulmonary disease and in a murine asthma model, which may predispose the hosts to bacterial infections, leading to disease exacerbations.
|
21239529 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of TLR2 and TLR4 on macrophages with increased sensitivity to hyaluronan fragments suggests a novel proinflammatory mechanism by which persistence of hyaluronan fragments could contribute to chronic inflammation and airway remodeling in asthma.
|
21570715 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate main effects and gene-gene interactions of haplotype tagging single nucleotide polymorphisms of genes involved in regulatory T-cell function-IL6, IL6R, IL10, heme-oxygenase 1 (HMOX1), IL2, Toll-like receptor 2 (TLR2), TGFB1, TGF-beta receptor (TGFBR)-1, TGFBR2, IL2RA, and forkhead box protein 3 (FOXP3)-in relation to atopy and asthma.
|
20599261 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that a genetic variant in the TLR2 subfamily may play a role in susceptibility to asthma.
|
20815312 |
2010 |