|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, a novel association between a functional polymorphism in TLR4 and ulcerative colitis is reported.
|
15207785 |
2004 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Most studies have focused on TLR2, TLR3, and TLR4 participation in UC.
|
22185629 |
2011 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
To investigate the effects and the underlying mechanism of HU210 action on the UC in relation to a role of TLR4 and MAP kinase signaling.
|
27995407 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.
|
15194649 |
2004 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Of the six TLRs (TLRs 1, 2, 4, 5, 6 and 9) examined, only TLR-4 was increased significantly in IBD, specifically in active UC.
|
26462859 |
2016 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the associations between polymorphisms TLR4 Asp299Gly and CD14 C-260T and Chinese patients with ulcerative colitis (UC).
|
16085746 |
2005 |
|
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
There was a significant decrease of NHE-1 and a significant increase (P < 0.05) of TLR-4, MyD88 and NFkB protein levels in the untreated UC or 5'-ASA plus steroid treated UC patients as compared to the controls.
|
21221801 |
2011 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
EGCG can inhibit the intestinal inflammatory response by reducing the severity of ulcerative colitis and maintaining the Th1/Th2 balance through the TLR4/MyD88/NF-<i>κ</i>B signaling pathway.
|
29404307 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We observed that the R702W and 1007fs Nod2 alleles and the A299G Tlr4 alleles were significantly more prevalent in patients with CD as compared to healthy controls or patients with ulcerative colitis.
|
16010583 |
2005 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the regulatory mechanism of mesalazine (MSLZ) on microRNA-21, microRNA-31 and Toll-like receptor 4/myeloid differentiation primary response 88 (TLR4/MyD88)-dependent pathway in 2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol-induced ulcerative colitis (UC) model in mice.
|
31378906 |
2019 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were found between Crohn's disease (CD) and minor NOD2 variants, as well as TLR4 299Gly, TNF-α G-308A, IL-6 G-174C and IL-1RN VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN VNTR A2 variants.
|
26316104 |
2015 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.
|
17850411 |
2007 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
A trend for an association between BPI and TLR4 was observed in UC patients, but failed to reach statistical significance.
|
19275920 |
2009 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
All-Trans Retinoic Acid Modulates TLR4/NF-<i>κ</i>B Signaling Pathway Targeting TNF-<i>α</i> and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer.
|
28408791 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Allele and genotype frequencies of NOD2/CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD patients, in 45 UC patients, and in 103 healthy controls.
|
18680223 |
2008 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
To investigate whether variants in NOD2/CARD15 and TLR4 are associated with CD and ulcerative colitis (UC) in a genetically admixed population of Rio de Janeiro, where IBD has continued to rise.
|
27107867 |
2016 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Despite the mutant TLR-4 predisposition for UC pancolitis, smoking was associated with more limited disease (P < 0.001).
|
22918682 |
2013 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
MiR-146a regulates the development of ulcerative colitis via mediating the TLR4/MyD88/NF-κB signaling pathway.
|
30915760 |
2019 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15-1.48; P=0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16-1.54; P=0.000035) but not ulcerative colitis.
|
17538633 |
2007 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In contrast, pattern recognition-mediated innate immune pathways (TLR4 and TLR2) were significantly elevated in UC but not in CD.
|
30517639 |
2019 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IRF5, but not TLR4, DEFB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population.
|
23971939 |
2013 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No association of IBD with the TLR4 single-nucleotide polymorphism was found in either cohort (UC p = 0.430, CD p = 0.783 vs. UC p = 0.745, CD p = 0.383).
|
18174680 |
2007 |