|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, a novel association between a functional polymorphism in TLR4 and ulcerative colitis is reported.
|
15207785 |
2004 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC.
|
15194649 |
2004 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the associations between polymorphisms TLR4 Asp299Gly and CD14 C-260T and Chinese patients with ulcerative colitis (UC).
|
16085746 |
2005 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We observed that the R702W and 1007fs Nod2 alleles and the A299G Tlr4 alleles were significantly more prevalent in patients with CD as compared to healthy controls or patients with ulcerative colitis.
|
16010583 |
2005 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Association between Toll-like receptor 4 and inflammatory bowel disease.
|
15905704 |
2005 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
LHGDN |
Additionally, 51.67% of the CD patients were carriers of a TLR4 and/or CD14 polymorphic allele and at least one variant of the NOD2/CARD15, compared to 27% of the UC patients.
|
15655821 |
2005 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The 299Gly TLR4 allele was identified in one UC and one CD patient.Conclusion.
|
16840031 |
2006 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.
|
17850411 |
2007 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15-1.48; P=0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16-1.54; P=0.000035) but not ulcerative colitis.
|
17538633 |
2007 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No association of IBD with the TLR4 single-nucleotide polymorphism was found in either cohort (UC p = 0.430, CD p = 0.783 vs. UC p = 0.745, CD p = 0.383).
|
18174680 |
2007 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Coding variants in TLR4 have been associated with autoimmune diseases like ulcerative colitis, Crohn's disease, and rheumatoid arthritis.
|
17927684 |
2007 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Allele and genotype frequencies of NOD2/CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD patients, in 45 UC patients, and in 103 healthy controls.
|
18680223 |
2008 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
A trend for an association between BPI and TLR4 was observed in UC patients, but failed to reach statistical significance.
|
19275920 |
2009 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast, PAB and GAB antibodies were not associated with NOD2/CARD15 or TLR4, response to medical therapy, or need for surgery.No associations were found in UC.
|
18972554 |
2009 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additional well-powered studies of the association between TLR4 variants and UC are needed.
|
20093834 |
2010 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Most studies have focused on TLR2, TLR3, and TLR4 participation in UC.
|
22185629 |
2011 |
|
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
There was a significant decrease of NHE-1 and a significant increase (P < 0.05) of TLR-4, MyD88 and NFkB protein levels in the untreated UC or 5'-ASA plus steroid treated UC patients as compared to the controls.
|
21221801 |
2011 |
|
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Mice transgenic for a constitutively active TLR4 under the intestine-specific villin promoter (villin-TLR4 mice) were treated with dextran sodium sulfate (DSS) for acute colitis and azoxymethane (AOM)-DSS TLR4 expression was analyzed by immunohistochemistry in colonic tissue from patients with ulcerative colitis (UC) and UC-associated cancer.
|
21674704 |
2011 |
|
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Polymorphisms in CD14-159C > T and TLR4-299A > G significantly affected mCD14 and mTLR4 expression levels and also increased susceptibility to UC.
|
22192785 |
2012 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.
|
23239925 |
2012 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Despite the mutant TLR-4 predisposition for UC pancolitis, smoking was associated with more limited disease (P < 0.001).
|
22918682 |
2013 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IRF5, but not TLR4, DEFB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population.
|
23971939 |
2013 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |