|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
A trend for an association between BPI and TLR4 was observed in UC patients, but failed to reach statistical significance.
|
19275920 |
2009 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Additional well-powered studies of the association between TLR4 variants and UC are needed.
|
20093834 |
2010 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
LHGDN |
Additionally, 51.67% of the CD patients were carriers of a TLR4 and/or CD14 polymorphic allele and at least one variant of the NOD2/CARD15, compared to 27% of the UC patients.
|
15655821 |
2005 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
All-Trans Retinoic Acid Modulates TLR4/NF-<i>κ</i>B Signaling Pathway Targeting TNF-<i>α</i> and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer.
|
28408791 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Allele and genotype frequencies of NOD2/CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD patients, in 45 UC patients, and in 103 healthy controls.
|
18680223 |
2008 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
ANRIL/miR-323b-5p/TLR4/MyD88/NF-κB pathway may provide a new strategy for UC therapy.
|
30477744 |
2019 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Association between Toll-like receptor 4 and inflammatory bowel disease.
|
15905704 |
2005 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Coding variants in TLR4 have been associated with autoimmune diseases like ulcerative colitis, Crohn's disease, and rheumatoid arthritis.
|
17927684 |
2007 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Despite the mutant TLR-4 predisposition for UC pancolitis, smoking was associated with more limited disease (P < 0.001).
|
22918682 |
2013 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
EGCG can inhibit the intestinal inflammatory response by reducing the severity of ulcerative colitis and maintaining the Th1/Th2 balance through the TLR4/MyD88/NF-<i>κ</i>B signaling pathway.
|
29404307 |
2017 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, a novel association between a functional polymorphism in TLR4 and ulcerative colitis is reported.
|
15207785 |
2004 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast, PAB and GAB antibodies were not associated with NOD2/CARD15 or TLR4, response to medical therapy, or need for surgery.No associations were found in UC.
|
18972554 |
2009 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In contrast, pattern recognition-mediated innate immune pathways (TLR4 and TLR2) were significantly elevated in UC but not in CD.
|
30517639 |
2019 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, increased expression of PTPRO, toll-like receptor (TLR4) and inflammatory cytokines were observed in mucosal tissues (MTs) from inflamed areas and lamina propria mononuclear cells (LPMCs) of patients with UC compared with those from healthy controls.
|
31452237 |
2020 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to determine whether TLR4 gene was associated with Crohn's disease (CD) and ulcerative colitis (UC) among Moroccan patients, and evaluated its correlation with clinical manifestation of the disease.
|
25492126 |
2014 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, TLR4 Asp299Gly polymorphism was significantly associated with increased risk of CD and UC in all genetic models, except for the additive one in CD.
|
26023918 |
2015 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IRF5, but not TLR4, DEFB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population.
|
23971939 |
2013 |
|
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Mice transgenic for a constitutively active TLR4 under the intestine-specific villin promoter (villin-TLR4 mice) were treated with dextran sodium sulfate (DSS) for acute colitis and azoxymethane (AOM)-DSS TLR4 expression was analyzed by immunohistochemistry in colonic tissue from patients with ulcerative colitis (UC) and UC-associated cancer.
|
21674704 |
2011 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
MiR-146a regulates the development of ulcerative colitis via mediating the TLR4/MyD88/NF-κB signaling pathway.
|
30915760 |
2019 |
|
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Most studies have focused on TLR2, TLR3, and TLR4 participation in UC.
|
22185629 |
2011 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No association of IBD with the TLR4 single-nucleotide polymorphism was found in either cohort (UC p = 0.430, CD p = 0.783 vs. UC p = 0.745, CD p = 0.383).
|
18174680 |
2007 |