|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data show for the first time that otherwise noninjurious mechanical ventilation can exacerbate ALI due to extrapulmonary sepsis underscoring a potential interactive contribution of common events (sepsis and mechanical ventilation) in critical care, and that a WISP1-TLR4-integrin β5 pathway contributes to this phenomenon.
|
30445996 |
2018 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis.
|
24878008 |
2015 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The activation of the TLR4/TLR9/p38 MAPK/STAT3 signal pathway contributes to the production of miR-23b in CLP-induced sepsis. miR-23b inhibitor decreased the number of spleen cells positive by terminal deoxynucleotidyl transferase dUTP nick-end labeling and improved survival. miR-23b inhibitor restored the immunoreactivity by alleviating the development of T-cell exhaustion and producing smaller amounts of immunosuppressive interleukin 10 and interleukin 4 during late sepsis.
|
29506272 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Some TLR4 modulators are undergoing preclinical and clinical evaluation for the treatment of sepsis, inflammatory diseases, cancer, and rheumatoid arthritis.
|
25515751 |
2014 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, GLN has a potential therapeutic effect in the protection against cardiac dysfunction mediated by sepsis through regulating the TLR4/MAPK/NF-κB signaling pathway.
|
29285127 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
|
20525286 |
2010 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The IL-1 receptor-associated kinase (IRAK-1) plays a central role in TLR2- and TLR4-induced activation of nuclear factor (NF)-kappaB, a critical event in the transcriptional regulation of many sepsis-associated proinflammatory mediators.
|
16528020 |
2006 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Sch B could increase miR-17-5p expression, promote inflammation, and decrease TLR4 expression in sepsis mice and LPS-induced macrophages.
|
30506107 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly, negative correlation between Toll-like receptor 4 (TLR4) and FAM46C in sepsis was observed.
|
30910647 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bacterial lipopolysaccharide (LPS), mainly functioning by stimulating toll-like receptor 4 (TLR4), mediates platelet activation and sepsis.
|
29653689 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Candidate single nucleotide polymorphisms (SNPs) within bacterial recognition (TLR4 +896, CD14 -159) and inflammatory response (TNF-alpha -308, IL-1beta -31, IL-6 -174) loci were evaluated for association with increased risk for severe sepsis (sepsis plus organ dysfunction or septic shock) and mortality.
|
15520404 |
2004 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
<i>Sch B</i> could protect against LPS-induced sepsis via the TLR4/NF-κB/MyD88 signaling pathway, and potentially be a novel anti-inflammatory and immunosuppressive drug candidate for treating sepsis.
|
29736208 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
ULI administration may improve patient outcome by reducing the spinal inflammation through a mechanism involving the TLR4/MyD88/NF-κB signaling in sepsis.
|
28796387 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, preemptive clinical sedative doses of DXM may upregulate the expression of caveolin‑1 downregulated by sepsis, which may contribute to the inhibition of inflammatory pathways such as TLR4‑mediated pathways.
|
28000867 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expressions of TLR4 and NF-κB p65 protein were significantly lower in simvastatin-treated rats than that in sepsis rats at the same time point.
|
28800541 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some, but not all, epidemiological studies have suggested that Toll-like receptor 4 (TLR4) polymorphisms, Asp299Gly and Thr399Ile, may influence the risk of at-risk patients for sepsis.
|
22537674 |
2012 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that TLR4 stimulation and human sepsis activate pathways that couple NAD(+) and its sensor SIRT1 with epigenetic reprogramming.
|
21245135 |
2011 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248925 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data indicate that HMGB1 accumulates in renal tissue and enters the urine and the interaction between HMGB1 and TLR4 turns TECs into inflammatory promoters during sepsis.
|
26312770 |
2016 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of TLR4 modulates vascular smooth muscle cells (VSMCs) phenotype and contributes to cardiovascular changes after sepsis.
|
31794773 |
2020 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Gram-negative bacterial lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) mediated pro-inflammatory signaling plays a key role in immunoprotection against infectious challenges and boosts adaptive immunity, whereas the activation of the cytosolic LPS receptor caspase-4/11 leads to cell death by pyroptosis and is deeply implicated in the development of sepsis.
|
29780528 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease.
|
18034244 |
2008 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis.
|
21968286 |
2012 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate whether organ failure in sepsis patients is related to the TLR4 rs11536889 genotype.
|
24950711 |
2014 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effect of TLR4/MyD88 signaling pathway on sepsis-associated acute respiratory distress syndrome in rats, via regulation of macrophage activation and inflammatory response.
|
29545858 |
2018 |