Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
|
20525286 |
2010 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Candidate single nucleotide polymorphisms (SNPs) within bacterial recognition (TLR4 +896, CD14 -159) and inflammatory response (TNF-alpha -308, IL-1beta -31, IL-6 -174) loci were evaluated for association with increased risk for severe sepsis (sepsis plus organ dysfunction or septic shock) and mortality.
|
15520404 |
2004 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some, but not all, epidemiological studies have suggested that Toll-like receptor 4 (TLR4) polymorphisms, Asp299Gly and Thr399Ile, may influence the risk of at-risk patients for sepsis.
|
22537674 |
2012 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease.
|
18034244 |
2008 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis.
|
21968286 |
2012 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate whether organ failure in sepsis patients is related to the TLR4 rs11536889 genotype.
|
24950711 |
2014 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Combined with our previous in vitro functional study, the results suggest that the TLR4 11367 polymorphism might be a good predictor of who is more likely to develop complications such as sepsis or multiple organ dysfunction syndrome, depending on genotype.
|
20026833 |
2009 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Specific point mutations in the human toll-like receptor 4 (TLR4) confer altered risk for diverse diseases including sepsis, aspergillosis and inflammatory bowel disease.
|
30885307 |
2019 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To simulate sepsis, male C57BL/6 (wild-type) and C57BL/10ScNJNJU (TLR4<sup>-/-</sup>) mice were subjected to cecal ligation and puncture (CLP).
|
29149705 |
2018 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Serum levels of tumour necrosis factor, interleukin (IL)-10, and IL-6 at sepsis onset did not significantly differ between patients carrying wild-type and mutant TLR4.
|
12807489 |
2003 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis.
|
12404174 |
2002 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis.
|
17989521 |
2007 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Examples include variants of TLR4 in sepsis, malaria, inflammatory bowel disease and atherosclerosis; variants in TLR2 in tuberculosis and asthma; a variant in Mal (a key signal for TLR2 and TLR4) in malaria, tuberculosis and systemic lupus erythematosus; and variants in the kinase IRAK4 in pyogenic infections.
|
20375592 |
2009 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Adjusting for independent risk factors, carriage of the variant TLR4 896 G allele was associated with decreased risk of complicated sepsis (odds ratio = 0.3, 95% confidence interval, 0.1-0.7, p = 0.008).
|
19131814 |
2009 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The toll-like receptor 4/2242 polymorphism is a functional variant and might be used as a relevant risk estimate for organ dysfunction and sepsis in trauma patients.
|
20228685 |
2010 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Consequently, this study was not able to detect associations between TLR4 polymorphisms and sepsis in this population.
|
23871732 |
2013 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of this meta-analysis suggest that the rs4986790 and rs4986791 polymorphisms in toll like receptor 4 gene may have no statistically significant influence on sepsis susceptibility.
|
27958344 |
2016 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14 were significantly associated with the risk of sepsis when compared to the control group.
|
25394369 |
2014 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis.
|
25454804 |
2015 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data show for the first time that otherwise noninjurious mechanical ventilation can exacerbate ALI due to extrapulmonary sepsis underscoring a potential interactive contribution of common events (sepsis and mechanical ventilation) in critical care, and that a WISP1-TLR4-integrin β5 pathway contributes to this phenomenon.
|
30445996 |
2018 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Some TLR4 modulators are undergoing preclinical and clinical evaluation for the treatment of sepsis, inflammatory diseases, cancer, and rheumatoid arthritis.
|
25515751 |
2014 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, GLN has a potential therapeutic effect in the protection against cardiac dysfunction mediated by sepsis through regulating the TLR4/MAPK/NF-κB signaling pathway.
|
29285127 |
2017 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly, negative correlation between Toll-like receptor 4 (TLR4) and FAM46C in sepsis was observed.
|
30910647 |
2019 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bacterial lipopolysaccharide (LPS), mainly functioning by stimulating toll-like receptor 4 (TLR4), mediates platelet activation and sepsis.
|
29653689 |
2018 |