|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
<i>Sch B</i> could protect against LPS-induced sepsis via the TLR4/NF-κB/MyD88 signaling pathway, and potentially be a novel anti-inflammatory and immunosuppressive drug candidate for treating sepsis.
|
29736208 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Toll receptors and sepsis.
|
11805536 |
2001 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis.
|
28976923 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis.
|
29343440 |
2018 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TLR4 is of particular interest, since over-stimulation of its pathway by excess lipopolysaccharide (LPS) molecules from the outer membranes of Gram-negative bacteria can result in sepsis, which causes millions of deaths each year.
|
31351116 |
2019 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of TLR4 modulates vascular smooth muscle cells (VSMCs) phenotype and contributes to cardiovascular changes after sepsis.
|
31794773 |
2020 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248925 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248930 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Acute hepatic dysfunction associating sepsis is mediated mainly by toll-like receptor-4 (TLR-4)/nuclear factor kappa-B (NF-κB) inflammatory pathway.
|
28189063 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Adjusting for independent risk factors, carriage of the variant TLR4 896 G allele was associated with decreased risk of complicated sepsis (odds ratio = 0.3, 95% confidence interval, 0.1-0.7, p = 0.008).
|
19131814 |
2009 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alkaline phosphatase (AP) is currently being investigated as an anti-inflammatory agent for detoxifying LPS through dephosphorylating lipid A, thus providing a potential treatment for managing both acute (sepsis) and chronic (metabolic endotoxemia) pathologies wherein aberrant TLR4/MD2 activation has been implicated.
|
31704704 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Allicin Improves Lung Injury Induced by Sepsis via Regulation of the Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Primary Response 88 (MYD88)/Nuclear Factor kappa B (NF-κB) Pathway.
|
30957795 |
2019 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although TLR-4 mRNA expression in healthy control monocytes could be modulated in vitro by culture with lipopolysaccharide or interleukin-10, this was not observed in monocytes obtained from sepsis and ITU control subjects, suggesting that septic and ITU control milieus may alter the immunoregulation of TLR-4 mRNA expression on monocytes.
|
15086396 |
2004 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
As compared to sham surgery, polymicrobial sepsis dampened malignant tumor growth in wild-type (WT) mice, but neither in <i>Toll-like receptor 4</i> (<i>Tlr4)<sup>-/-</sup></i> nor in <i>Myd88<sup>-/-</sup></i> mice.
|
31646090 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bacterial lipopolysaccharide (LPS), mainly functioning by stimulating toll-like receptor 4 (TLR4), mediates platelet activation and sepsis.
|
29653689 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because TcpB suppresses both TLR4- and caspase-4/11-mediated inflammation, TcpB might be a candidate target for developing drugs against LPS-induced septicemia.
|
29061850 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis.
|
17989521 |
2007 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Candidate single nucleotide polymorphisms (SNPs) within bacterial recognition (TLR4 +896, CD14 -159) and inflammatory response (TNF-alpha -308, IL-1beta -31, IL-6 -174) loci were evaluated for association with increased risk for severe sepsis (sepsis plus organ dysfunction or septic shock) and mortality.
|
15520404 |
2004 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Circulating histones contribute to inflammation, and to lethality in sepsis, a hyperinflammatory condition, by interacting with specific receptors, notably toll-like receptor 4 (TLR4).
|
29997623 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Collectively, the results from the current study demonstrate CD16 as a key regulator of the TRIF-dependent TLR4 pathway in human monocytes and their CD16-expressing subset, with implications in sepsis.
|
22427642 |
2012 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Combined with our previous in vitro functional study, the results suggest that the TLR4 11367 polymorphism might be a good predictor of who is more likely to develop complications such as sepsis or multiple organ dysfunction syndrome, depending on genotype.
|
20026833 |
2009 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Consequently, this study was not able to detect associations between TLR4 polymorphisms and sepsis in this population.
|
23871732 |
2013 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Dex pretreatment protects against LPS-induced ALI via inhibiting the activation of the TLR-4/NF-kB signaling pathway by upregulating the expression of Cav-1 downregulated by sepsis.
|
31545263 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
During hemorrhagic shock and sepsis, inflammation triggers the translocation of CIRP from the nucleus to the cytosol and its release to the extracellular space. eCIRP then induces inflammatory responses in macrophages, neutrophils, lymphocytes, and dendritic cells. eCIRP also induces endoplasmic reticulum stress and pyroptosis in endothelial cells by activating the NF-κB and inflammasome pathways, and necroptosis in macrophages via mitochondrial DNA damage. eCIRP works through the TLR4-MD2 receptors.
|
30645013 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effect of TLR4/MyD88 signaling pathway on sepsis-associated acute respiratory distress syndrome in rats, via regulation of macrophage activation and inflammatory response.
|
29545858 |
2018 |