TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0394996
Disease: Acute alcoholic intoxication
Acute alcoholic intoxication 		0.020 GeneticVariation disease BEFREE The present study aims to assess plasma cytokine and chemokine levels in male and female adolescents and young adults during acute alcohol intoxication and to correlate these results with the toll-like receptor 4 (TLR4) response. 27699959 2017
CUI: C0701807
Disease: Acute anterior uveitis
Acute anterior uveitis 		0.030 GeneticVariation disease BEFREE The purpose of this study was to investigate the role of TLR2 and TLR4 gene polymorphisms in the pathogenesis of AAU. 22128242 2011
CUI: C0701807
Disease: Acute anterior uveitis
Acute anterior uveitis 		0.030 Biomarker disease BEFREE IL-6 and IFN-gamma production stimulated by TLR4 activation was significantly reduced in patients with AAU, compared with that in healthy control subjects (P < 0.05). 17389503 2007
CUI: C0701807
Disease: Acute anterior uveitis
Acute anterior uveitis 		0.030 Biomarker disease BEFREE Increased expression of miRNA146a (p<0.01), miRNA155 (p<0.05) and miRNA125a5p (p<0.01) was demonstrated in AU PBMC compared with HC. miRNA155 was increased following TLR1/2 (p<0.05) and TLR4 (p<0.05) stimulation and miRNA146a increased in response to IL1β (p<0.05). 30297336 2019
CUI: C0241868
Disease: acute aortic dissection
acute aortic dissection 		0.010 Biomarker disease BEFREE Either serum MMP9 or TLR4 was independently associated with the risk of AAD (all p < 0.001). 30497388 2018
CUI: C0582415
Disease: Acute asthma
Acute asthma 		0.010 Biomarker disease BEFREE Saxagliptin mitigates airway inflammation in a mouse model of acute asthma via modulation of NF-kB and TLR4. 31678284 2019
CUI: C0001311
Disease: Acute bronchiolitis
Acute bronchiolitis 		0.010 GeneticVariation disease BEFREE We found no association between TLR4 polymorphisms (Asp299Gly and Thr399Ile) and the development of acute bronchiolitis. 25572736 2015
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents 		0.010 Biomarker disease BEFREE TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models. 29910175 2018
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 AlteredExpression disease BEFREE We suggest that TLR4 and MAPK families maybe involved in activation of circulating DC of ACS patients. 18373609 2008
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 Biomarker disease BEFREE Pharmacologic inhibition of TLR4 and hemopexin replacement therapy prior to hemin infusion protected sickle mice from developing ACS. 24084741 2013
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 AlteredExpression disease BEFREE We found that mRNA expression levels of TLR2 but not TLR 4 and 9 are up-regulated in platelets of patients with ACS when compared to patients without coronary atherosclerosis. 31644579 2019
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 Biomarker disease BEFREE TLR4, miR-155, and inflammatory cytokines may be closely related to ACS. 28407320 2018
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 Biomarker disease BEFREE S100A8/A9 expression was significantly correlated with TLR-4 and COX-2 in the ACS group and with TLR-4 in the CHD group. 30367682 2018
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 AlteredExpression disease BEFREE The TLR4 expression levels were significantly higher in the ACS group than in the SAP group. 19556696 2009
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.070 Biomarker disease BEFREE TLR-4 might play a more important role than TLR-2 in atherogenesis, especially in ACS. 25179298 2016
CUI: C2118460
Disease: Acute colitis
Acute colitis 		0.030 Biomarker disease BEFREE Interestingly, WT mice cohoused with villin-TLR4 mice displayed greater susceptibility to acute colitis than singly housed WT mice did. 26755160 2016
CUI: C2118460
Disease: Acute colitis
Acute colitis 		0.030 AlteredExpression disease BEFREE In vivo, mucosal EPI and AR expression are significantly decreased in TLR4(-/-) mice (P=0.02) compared to wild-type mice during acute colitis. 20498653 2010
CUI: C2118460
Disease: Acute colitis
Acute colitis 		0.030 Biomarker disease BEFREE As compared to wt animals, TLR2(-/-), TLR4(-/-), and TLR2/4(-/-) mice displayed reduced macroscopic signs of acute colitis and the amelioration of inflammation was associated with reduced IFN-gamma levels in mesenteric lymph nodes, lower amounts of neutrophils, and less FOXP3-positive T-cells in the colon in situ. 17653282 2007
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.340 AlteredExpression disease BEFREE Toll-like receptor-4 is upregulated in plaque debris of patients with acute coronary syndrome more than Toll-like receptor-2. 25179298 2016
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.340 GeneticVariation disease LHGDN These results, which must be confirmed by a prospective longitudinal study, provide evidence of an association between the Asp299Gly polymorphism of the human TLR4 receptor and acute coronary syndromes. 14563652 2003
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.340 Biomarker disease CTD_human The study aims to explore the relationship between expressions of toll-like receptor 4 (TLR4) on peripheral blood monocytes, serum tumor necrosis factor-alpha (TNF-α) and matrix metalloproteinase-9 (MMP-9) in patients with acute coronary syndromes(ACS), and to investigate the possible mechanisms of Benazepril stabilizing atherosclerosis plaques. 20981132 2010
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.340 GeneticVariation disease BEFREE These results, which must be confirmed by a prospective longitudinal study, provide evidence of an association between the Asp299Gly polymorphism of the human TLR4 receptor and acute coronary syndromes. 14563652 2003
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.340 Biomarker disease BEFREE Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. 15883205 2005
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.340 AlteredExpression disease BEFREE The results showed that the expression of TLR4 and MAPK families are increased in the patients with acute coronary syndrome (ACS), compared with it in the patients with stable angina and controls. 18373609 2008
CUI: C0149523
Disease: Acute cystitis
Acute cystitis 		0.010 GeneticVariation disease BEFREE TLR4 (896) AG genotype and TLR4 (896) G allele had higher prevalence in UTI (especially in acute cystitis and urethritis) patients, whereas CXCR1 (2608) GC genotype and CXCR1 (2608) C allele had lower prevalence in UTI patients than controls. 21151974 2010