|
Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On subgroup analysis however, haplotype TNF-2 was more frequent in women with extensive colitis compared to distal colitis (31% vs 12%; P = 0.028).
|
11196710 |
2000 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
NOD2/CARD15 was associated with ileal involvement, while presence of TNF-863A was inversely associated with ileal disease (OR = 0.42, p= 0.008) and positively associated with isolated colitis (OR = 2.16, p= 0.008, OR = 2.12, p= 0.03 corrected) and familial disease (p= 0.004).
|
15667501 |
2005 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a prospective, multicenter, one-year study biologic naïve patients aged 25-65 years, with corticosteroid-dependent or refractory colitis received combination treatment with anti-TNFα and azathioprine for 6 months followed by anti-TNFα monotherapy.
|
27866814 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data suggested that SGK1 may protect IECs in colitis from tumor necrosis factor-α-induced apoptosis partly by triggering MEK/ERK activation.
|
26034353 |
2015 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neutralization of TNF-α in dextran sulfate sodium (DSS)-induced colitis mice demonstrates improved the outcomes, and the therapeutic effect of the TNF-α neutralizing mAb is mediated in part by the preservation of DRA expression.
|
29330471 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vivo: KLD significantly improves body weight, clinical score, histological score and large intestine length of mice with DSS-induced colitis and reduces TNF-α, IL-1β and IL-6 mRNA levels, while increases IL-10 mRNA and VDR levels.
|
29633636 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inulins inhibited the development of dextran sulfate sodium-induced colitis and colon cancer in mice; these fructans reduced the concentration of tumor necrosis factor alpha and prevented the formation of intestinal polyps, villous atrophy, and lymphoid hyperplasia.
|
28293641 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Administration of LMWH-NP at 500 IU/kg has markedly improved the clinical activity as compared to LMWH while similarly pathophysiological indicators revealed increased therapeutic outcome in presence of NP compared to LMWH alone: Myeloperoxidase (Colitis control: 10 480 ± 5335, LMWH-PEMT-A NP: 1507 ± 2165, LMWH-PEMT-B NP: 382 ± 143, LMWH: 8549 ± 5021 units/g) and tumor necrosis factor: (Colitis control: 1636 ± 544, LMWH-PEMT-A NP: 511 ± 506, LMWH-PEMT-B NP: 435 ± 473, LMWH: 1110 ± 309 pg/g).
|
28509629 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cux1 expression increased in cultured intestinal epithelial cells stimulated with tumor necrosis factor alpha (TNFα), in the mouse intestinal epithelium during experimental colitis and in human IBD patient samples.
|
20848487 |
2010 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
However a role of TNF-α in the regulation of NHE-2 is discounted in the present model of colitis.
|
28493993 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The loss of NLRX1 results in increased disease severity, populations of Th1 and Th17 cells, and inflammatory markers (IFN-γ, TNF-α, and IL-17) in mice with dextran sodium sulfate-induced colitis.
|
28159898 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim was to investigate the expression of CDX2 and MEP1A in colitis; to assess if they are regulated by tumor necrosis factor-α (TNF-α), and finally to reveal if CDX2 is involved in a TNF-α-induced down-regulation of MEP1A.
|
22326557 |
2012 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colitis was induced in mice by transfer of CD4+CD45RB<sup>hi</sup> to FcγR<sup>-/-</sup>Rag1<sup>-/-</sup> or Rag1<sup>-/-</sup> littermates; mice were given different antibodies against TNF or isotype (control) antibodies and disease activity index scores were determined.
|
28756234 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
DAI evaluation, colon length, colon tissue morphology, histologic damage scores and relative protein concentrations (MPO, TNF-α and IL-1β) demonstrated that the Alg/Chi/IL-1Ra microcapsules alleviated DSS-induced colitis in mice.
|
30779979 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inhibition of the tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) system reduces intestinal cell death and disease development in several models of colitis.
|
26012567 |
2015 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Additionally, huperzine A was effective to reverse colitis-induced high lucigenin-enhanced CL values and serum TNF-α levels.
|
23810507 |
2013 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified a pteridine derivative, 4AZA2096, with strong inhibitory activity on TNF production and a remission- inducing effect in TNBS colitis, supporting further preclinical and clinical development of this novel TNF inhibitor for treatment of inflammatory diseases.
|
16881868 |
2006 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found the BAG-1 isoform BAG-1M upregulated threefold in human Caco-2 cells following stimulation with tumor necrosis factor receptor α (TNFα) to induce a pro-inflammatory response, and up to sixfold in mouse enterocytes following treatment with dextran sodium sulfate (DSS) to induce colitis.
|
24876225 |
2014 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation.
|
24548422 |
2014 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
High mucosal TNFα concentrations were observed in αCTLA-4-induced colitis.
|
28967957 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that the LB-9 probiotic exhibits therapeutic potential for UC through suppression of TNF-α-mediated IEC apoptosis in a murine DSS-induced colitis model, with important biological implications for treatment of IBD in humans.
|
30615542 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we use wildtype (WT) and mice lacking Tnf (Tnf-/-) in an acute TNBS colitis model to investigate the role of TNF in colitis and how its presence or absence affects the colonic microbiota.
|
25775453 |
2015 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, this study determines the levels of miR-19a and TNF-α in both DSS-induced experimental murine colitis and human UC and further demonstrates that miR-19a might directly regulate TNF-α.
|
23795660 |
2013 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Treatment with M1 and its derivatives M2-M4 significantly inhibited TNF-alpha-induced attachment of U937 monocytic cells to HT-29 cells, which mimics the initial phase of colon inflammation.
|
19765578 |
2009 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Next, we orally administered GC-modified NPs loaded with TNF-α siRNA to C57BL/6 mice treated with 3% dextran sodium sulfate (DSS) to investigate their use in the treatment of colitis.
|
30315858 |
2018 |