Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
TNF-α and PON total methylation levels correlated each other (r = 0.44; p = 0.031), especially in stroke patients (r = 0.72; p = 0.008).
|
24500802 |
2014 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings indicate the important roles that TNF-α and IL-1β serum levels play regarding the risk of PSD, particularly during the acute phase of stroke and in patients with genetic susceptibility.
|
28844626 |
2017 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Up-regulated TNF-α expression has also been found in various neurodegenerative diseases such as cerebral malaria, AIDS dementia, Alzheimer's disease, multiple sclerosis, and stroke, suggesting a potential pathogenic role of TNF-α in these diseases as well.
|
21298033 |
2011 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Serum levels of TNF-α, C-reactive protein (CRP), IL-4, IL-6, IL-10, IL-17, IL-23, and TGF-β increased, whereas serum level of IFN-γ decreased at all time points after stroke.
|
27682880 |
2017 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Quantitative PCR analysis of whole cell lysate as well as flow-sorted myeloid cells from the perilesional cortex showed increased cellular interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) mRNA levels but reduced plasma levels of these cytokines in MS P2X4R KO mice after stroke.
|
28751018 |
2017 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Moreover, plasma H19 levels showed a positive correlation with National Institute of Health Stroke Scale score and tumor necrosis factor-α levels.
|
28630232 |
2017 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
<b>Results:</b> MCAo resulted in profound attenuation of immune activation, as anticipated. t-PA treatment not only worsened neurological deficit, but further reduced lymphocyte and monocyte counts in blood, enhanced plasma levels of both IL-10 and TNFα and decreased various conventional DC subsets in the spleen and cLN, consistent with enhanced immunosuppression and systemic inflammation after stroke.
|
30972077 |
2019 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
LHGDN |
The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke.
|
14681891 |
2003 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We investigated whether gradual increases in tumor necrosis factor-alpha (TNF-alpha) reported during exercise down-regulates expression of TNF-alpha receptors I and II (TNFRI and II) in stroke, leading to reduced brain damage.
|
17109621 |
2006 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Injection of lentiviral miR-126-5p improved behavioral outcomes at 3 days after stroke (<i>P</i><0.05). miR-126-3p and -5p overexpression downregulated the expression of proinflammatory cytokines IL-1β and TNF-α and adhesion molecules VCAM-1 and E-selectin, as well as decreased MPO<sup>+</sup> (myeloperoxidase positive) cell numbers at 3 days after ischemia (<i>P</i><0.05).
|
31822249 |
2020 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Alveolar macrophages and epithelial and endothelial cells of Sham and Stroke animals were also isolated for evaluation of mRNA expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α.
|
30290827 |
2018 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke.
|
30120034 |
2018 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation.
|
31440125 |
2019 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> Tumor necrosis factor-a-induced protein 8-like 2 (TIPE2) is a novel regulator of immunity and protects against experimental stroke.
|
30588195 |
2018 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
These data provide evidence that serum TNF-α and IL-1β concentrations are related to poor long-term outcomes after stroke in the presence of particular alleles.
|
29161722 |
2018 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
In inflammatory cytokines, increased cytokines [including interleukin (IL) 1beta, IL-18, tumor necrosis factor alpha] after stroke lead to depression.
|
19891854 |
2009 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Quantitative assessment of stroke outcome was evaluated by measuring infarct volume (by magnetic resonance imaging), cerebral blood flow (by laser speckle imaging), neurological and sensory-motor outcome, and postischemic thrombo-inflammation (platelet thrombi, fibrin, neutrophil, phospho-NFκB [nuclear factor κB], TNFα [tumor necrosis factor α], and IL1β [interleukin 1β]).
|
30909835 |
2019 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
The aim of this study was to evaluate the association of genetic variants within the genes encoding tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-3 (MMP-3), with stroke.
|
21219546 |
2011 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
There is increasing evidence on the role of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the occurrence and outcome of stroke.
|
15733973 |
2005 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Stroke survivors (50-76 years) underwent a fasting blood draw for measurement of TNF-α, IL-6, CRP, serum amyloid A, sICAM-1, sVCAM-1, and bilateral vastus lateralis biopsies before and after RT.
|
27955950 |
2017 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
This study suggests that delirium is not scarce in patients with AIS admitted to the non-intensive stroke unit, and that delirium developing after AIS seems not to be associated with serum TNF-alpha, IL-1 beta, IL-18, BDNF and NSE but is associated with length of hospital stay and stroke severity.
|
27816188 |
2017 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We investigated the role of inflammatory genes IL1B, IL6, MPO, and TNF in stroke susceptibility and recovery in a population sample of 672 patients and 530 controls, adjusting for demographic, clinical and lifestyle risk factors, and stroke severity parameters.
|
21407237 |
2011 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Polymorphic variants in genes encoding apoptotic proteins, either from the extrinsic (FAS, TNF-α, CASP8) or the intrinsic (BAX, BCL2, CASP3, CASP9) pathways could be highly valuable in the diagnosis of neurodegenerative diseases and stroke.
|
22695677 |
2013 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Cells that are resistant to apoptosis by Par-4 alone, however, are greatly sensitized by Par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, tumor necrosis factor, ionizing radiation, intracellular calcium elevation, or those involved in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and stroke.
|
12565819 |
2003 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke.
|
28611085 |
2017 |