Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PKCδ inhibition significantly reduced TNF-α-mediated hyperpermeability and TEER decrease in vitro in activated HBMVEC and rat brain in vivo 24 h after CLP induced sepsis.
|
30400800 |
2018 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Plasma cytokine (IL-1β and TNF-α) levels were increased in patients with sepsis exhibiting high mPR3 expression.
|
29621735 |
2018 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Plasma levels of miR-187 in sepsis patients were inversely correlated with those of TNF-α and IL-6 (r = -0.2841, -0.2163), and plasma levels of miR-21 and miR-145 were positively correlated with those of TNF-α and IL-6 (r = 0.615, 0.3057, 0.4465, 0.2734).
|
31415369 |
2019 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of IL-1beta/-1470, IL-1beta/-511, IL-1beta/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and TNFalpha/-308 are susceptibility loci for the development of sepsis and organ dysfunction in major trauma patients.
|
20217044 |
2010 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Possible explanations for these outcomes include immunologic response to sepsis by a leukemia-specific T-cell response or the release of various cytokines, such as tumor necrosis factor and interleukin-2, during infections.
|
22627572 |
2012 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Potential immunologic mechanisms responsible for the rhIL-7 putative beneficial effect were also examined, focusing on IL-17, IL-22, IFN-γ, and TNF-α, cytokines that are critical in the control of sepsis and pulmonary Pseudomonas infections.
|
27630218 |
2017 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results from association study indicated that trauma patients carrying the TNF-α/-308/A allele were more likely complicated with sepsis.
|
20805766 |
2011 |
Septicemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis.
|
15489642 |
2004 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum markers associated with the acute proinflammatory phase of sepsis (TNFα, IL-1β, and IL-6) rapidly increased and then progressively decreased during the 30-day period post-CLP, concomitant with a progressive increase in RAGE ligands (S100B, <i>N</i>ϵ-[carboxymethyl]lysine, HSP70, and HMGB1).
|
29127203 |
2018 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Significant reductions in the levels of circulating interleukin-6 (<i>P</i> = 0.046) and tumor necrosis factor-α (<i>P</i> = 0.008) were found in the sepsis group.
|
30666251 |
2018 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Single Nucleotide Polymorphisms (SNPs) at positions -238, -308, -376 and +489 in the promoter region of TNF gene exhibit differential association to inflammation and increased TNF production in sepsis.
|
23317877 |
2013 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
T-lymphocyte subsets were detected by flow cytometer, the levels of tumor necrosis factor-α, interleukin-1 and calcitonin were determined by double-antibody immunoluminometric assay, and the effect of vitamin D on the above indicators in the treatment of sepsis was observed.
|
30116318 |
2018 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The -308G >A TNF-α SNP effect was analyzed in the entire patient group, in patients with sepsis (349/520), and in those who developed septic shock (248/520).
|
21670923 |
2011 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TNFA minor A-allele group also had a higher Multiple Organ Failure score of 0.26 (95% CI: 0.03, 0.49; p = 0.024) after adjustment for sex, race, age, and sepsis.
|
23796916 |
2013 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The absence of TRPM2 triggered less production of inflammatory mediators (IL-1β, IL-6, TNF-α) and decreased apoptosis related proteins (BNIP3, AIF, Endo G) expressions in response to LPS induced sepsis.
|
31450153 |
2019 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The amount of TNF released in situations of severe infection and sepsis appears to be influenced genetically.
|
8625623 |
1996 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of AQP-5 in the sepsis group were significantly decreased compared with those in ctrl and SO groups (P<0.01), while the levels of TNF-α, IL-6 and p-P38 were significantly increased in sepsis group compared with those in ctrl and SO groups (P<0.01).
|
30127927 |
2018 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The influence of polymorphisms of the TNF locus on susceptibility to, and outcome from sepsis remains uncertain.
|
15526005 |
2004 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The levels of TNF-α were higher in patients with sepsis (P=0.03), and deceased patients (P=0.001).
|
31701129 |
2019 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The levels of TNF-α in the KO sepsis group were significantly higher than those of the WT sepsis group (P < .05).
|
31701658 |
2020 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The mouse model of sepsis was then established and the serum was extracted to detect interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).
|
30915758 |
2019 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The progression of OPG levels paralleled the deterioration of kidney and endothelial functions from sepsis to sepsis-AKI, revealed as progressively increased levels of serum E-selectin (15.3%), endothelin-1 (ET-1) (19.6%), and decreased nitric oxide (NO) (29.7%), associated with elevations of TNF-α (25.5%) and TGF-β (18%).
|
28840836 |
2017 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The protection of female hearts against the dysfunction associated with sepsis is (at least in part) attributable to cardiac activation of the Akt/eNOS survival pathway, decreased activation of NF-κB, and decreased expression of iNOS, TNF-α and IL-6.
|
24945834 |
2014 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results of the in vitro and in vivo experiments indicated that the levels of LPS, TNF-α and IL-6 of the palmatine group were significantly lower than those of the sepsis model group (p<0.01).
|
28278436 |
2017 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results revealed that combined treatment in pediatric burn sepsis patients decreased the inflammatory cytokine tumor necrosis factor α and interleukin (IL)-1β serum levels, whereas it increased IL-10 and human leukocyte antigen-D related levels.
|
29599842 |
2018 |