|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review explores some of the new elements of immunoinflammatory response in severe sepsis, tumor necrosis factor-alpha in severe acute pancreatitis as a clinical example of immune response in sepsis, immune response in severe trauma with or without secondary sepsis, and genetic aspects of host immuno-inflammatory response to various insults in critically ill patients.
|
24371374 |
2013 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This new mechanistic understanding of endothelial regulation and the modulation of tumor necrosis factor-induced endothelial dysfunction creates a novel link between coagulation, inflammation, and cell death and provides insight into the molecular basis for the efficacy of APC in systemic inflammation and sepsis.
|
11278252 |
2001 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the -308G/A gene polymorphism in the TNF-α gene may contribute to risk of sepsis and septic shock, but not risk of mortality.
|
29212277 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings indicated that the levels of TNF-α, IL-6, IL-8, PCT, ET-1 and IL-10 were associated with the condition and prognosis of elderly patients with sepsis, and the assessment system for immune levels based on the levels of these indicators was conducive to the stipulation of individualized immune regulation procedure and prognostic evaluation of sepsis.
|
30112039 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we hypothesized that TNF has a dual role in sepsis, namely a mediating and a protective role, and that protection might be obtained by TNFR1-specific inhibition.
|
31787972 |
2019 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the JNK1 and nNOS inhibitory pathways represent a "brake" that limits myocardial TNF-alpha expression in sepsis.
|
20237583 |
2010 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, culture- and next-generation sequencing (NGS)-based fungal findings as well as corresponding plasma levels of β-d-glucan, interferon gamma (INF-γ), tumor necrosis factor alpha (TNF-α), interleukin (IL)-2, -4, -6, -10, -17A, and mid-regional proadrenomedullin (MR-proADM) were evaluated in 50 septic patients at six consecutive time points within 28 days after sepsis onset.
|
28820494 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therapy with vitamin D in animal models of sepsis improves blood coagulation parameters in disseminated intravascular coagulation and modulates levels of systemic inflammatory cytokines including TNF-α and IL-6.
|
21777617 |
2011 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Then, Caco-2 monolayers were utilized to further investigate the protective effect of the EcN supernatant (EcN<sup>sup</sup>) on the barrier dysfunction induced by TNF-<i>α</i> and IFN-<i>γ</i> in vitro; the plasma level of both the cytokines increased significantly during sepsis.
|
31354386 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The α7 nAChR partial agonist GTS-21 reduces secretion of pro-inflammatory cytokines including interleukin-6 (IL6) and tumor-necrosis factor (TNF) in models of endotoxemia and sepsis, and its anti-inflammatory effects are widely ascribed to α7 nAChR activation.
|
30947238 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The whole peripheral blood samples obtained immediately after admission were stimulated with bacterial lipopolysaccharide and then determined for production of tumor necrosis factor α. Sepsis morbidity rate and multiple organ dysfunction (MOD) scores were accessed.
|
22266968 |
2012 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of TNF-α superfamily members in immunopathogenesis of sepsis.
|
30142533 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results revealed that combined treatment in pediatric burn sepsis patients decreased the inflammatory cytokine tumor necrosis factor α and interleukin (IL)-1β serum levels, whereas it increased IL-10 and human leukocyte antigen-D related levels.
|
29599842 |
2018 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results of the in vitro and in vivo experiments indicated that the levels of LPS, TNF-α and IL-6 of the palmatine group were significantly lower than those of the sepsis model group (p<0.01).
|
28278436 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The protection of female hearts against the dysfunction associated with sepsis is (at least in part) attributable to cardiac activation of the Akt/eNOS survival pathway, decreased activation of NF-κB, and decreased expression of iNOS, TNF-α and IL-6.
|
24945834 |
2014 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The progression of OPG levels paralleled the deterioration of kidney and endothelial functions from sepsis to sepsis-AKI, revealed as progressively increased levels of serum E-selectin (15.3%), endothelin-1 (ET-1) (19.6%), and decreased nitric oxide (NO) (29.7%), associated with elevations of TNF-α (25.5%) and TGF-β (18%).
|
28840836 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The mouse model of sepsis was then established and the serum was extracted to detect interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).
|
30915758 |
2019 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The levels of TNF-α in the KO sepsis group were significantly higher than those of the WT sepsis group (P < .05).
|
31701658 |
2020 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The levels of TNF-α were higher in patients with sepsis (P=0.03), and deceased patients (P=0.001).
|
31701129 |
2019 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The influence of polymorphisms of the TNF locus on susceptibility to, and outcome from sepsis remains uncertain.
|
15526005 |
2004 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of AQP-5 in the sepsis group were significantly decreased compared with those in ctrl and SO groups (P<0.01), while the levels of TNF-α, IL-6 and p-P38 were significantly increased in sepsis group compared with those in ctrl and SO groups (P<0.01).
|
30127927 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The amount of TNF released in situations of severe infection and sepsis appears to be influenced genetically.
|
8625623 |
1996 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The absence of TRPM2 triggered less production of inflammatory mediators (IL-1β, IL-6, TNF-α) and decreased apoptosis related proteins (BNIP3, AIF, Endo G) expressions in response to LPS induced sepsis.
|
31450153 |
2019 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TNFA minor A-allele group also had a higher Multiple Organ Failure score of 0.26 (95% CI: 0.03, 0.49; p = 0.024) after adjustment for sex, race, age, and sepsis.
|
23796916 |
2013 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The -308G >A TNF-α SNP effect was analyzed in the entire patient group, in patients with sepsis (349/520), and in those who developed septic shock (248/520).
|
21670923 |
2011 |