|
Degenerative polyarthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, we verified that PDX ameliorated cartilage degradation in monosodium iodoacetate (MIA)-induced OA rats through histological evaluation and ELISA of TNF-α in the serum and intra-articular lavage fluid.
|
31837574 |
2020 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A search strategy was developed using the terms: "Mood disorder" OR "Depressive Disorder" OR "Bipolar disorder" AND "Infliximab" OR "tumor necrosis factor antagonist" as text words and Medical Subject Headings (i.e., MeSH and EMTREE).
|
31837338 |
2020 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A search strategy was developed using the terms: "Mood disorder" OR "Depressive Disorder" OR "Bipolar disorder" AND "Infliximab" OR "tumor necrosis factor antagonist" as text words and Medical Subject Headings (i.e., MeSH and EMTREE).
|
31837338 |
2020 |
|
Mood Disorders
|
0.370 |
GeneticVariation
|
group |
BEFREE |
A search strategy was developed using the terms: "Mood disorder" OR "Depressive Disorder" OR "Bipolar disorder" AND "Infliximab" OR "tumor necrosis factor antagonist" as text words and Medical Subject Headings (i.e., MeSH and EMTREE).
|
31837338 |
2020 |
|
Depressive Disorder, Treatment-Resistant
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Studies have suggested that alterations in proinflammatory cytokines play an important role in the pathophysiology of TRD, as well as a significant relationship between the number of failed treatment and the levels of tumor necrosis factor-alpha (TNF-α).
|
31837338 |
2020 |
|
Cutaneous hypersensitivity
|
0.010 |
Biomarker
|
disease |
BEFREE |
MC-derived tumor necrosis factor (TNF) induces nerve growth factor (NGF) and participates in nerve fiber elongation in skin hypersensitivity.
|
31837249 |
2020 |
|
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gain- and loss-of-function studies revealed that FoxC1 overexpression promoted, whilst silencing inhibited OA synovial fibroblast (OASF) proliferation and pro-inflammatory cytokine (interleukin 6 (IL-6), interleukin 8 (IL-8), and tumour necrosis factor-α (TNF-α)) production.
|
31837247 |
2019 |
|
Oedema auricular
|
0.090 |
Biomarker
|
disease |
BEFREE |
Topical application of V. bifalcata reduced ear edema formation, cell infiltration and interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels.
|
31836516 |
2020 |
|
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that, compared to the OA group, the OA + treadmill and OA + wheel groups had lower levels of IL-1β, IL-6 and TNF-α, and similar levels of p-P65, p-JNK, and P-IκBα.
|
31836142 |
2020 |
|
Autistic Disorder
|
0.060 |
Biomarker
|
disease |
BEFREE |
Plasma levels of leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), macrophage chemoattractant protein-1 (CCL2), tumor necrosis factor-alfa (TNF-α), and interleukin-6 (IL-6) were correlated with clinical scores and were compared among different ASD subgroups according to the presence or absence of: (i) GI symptoms, (ii) regressive onset of autism.
|
31835709 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results exhibited that CB treatment prevented cognitive impairment, Aβ deposits, microglia activation and production of tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the brain of APP/PS1 mice.
|
31835282 |
2020 |
|
Influenza A
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mechanisms exploration revealed that MENK (10 mg/mL) significantly inhibited the nucleoprotein (NP) of influenza virus and up-regulated levels of IL-6, TNF-α and IFN-β compared with those in H1N1 control group.
|
31835089 |
2020 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Registries have been central in clarifying the risk of infection and malignancy with anti-TNF therapy, despite the limitations of selection and channelling bias, incomplete case capture, unmeasured confounding, and the inability to infer causality.
|
31834407 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Registries have been central in clarifying the risk of infection and malignancy with anti-TNF therapy, despite the limitations of selection and channelling bias, incomplete case capture, unmeasured confounding, and the inability to infer causality.
|
31834407 |
2020 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Mean ± SD tear TPC and TNF-α concentrations for normal were 7.10 ± 1.53 and 1.39 ± 0.24 pg/mL; for diabetes without retinopathy, 6.37 ± 1.65 and 1.53 ± 0.27 pg/mL; for mild NPDR, 6.32 ± 2.05 and 1.60 ± 0.21 pg/mL; for moderate NPDR, 3.88 ± 1.38 and 1.99 ± 0.05 pg/mL; and for severe NPDR, 3.64 ± 1.26 and 2.21 ± 0.04 pg/mL, respectively.
|
31834153 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study evaluated differences of TPC and TNF-α concentrations in tears at different severity of NPDR among participants with diabetes in comparison with normal participants.
|
31834153 |
2019 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
This study evaluated differences of TPC and TNF-α concentrations in tears at different severity of NPDR among participants with diabetes in comparison with normal participants.
|
31834153 |
2019 |
|
Nonproliferative diabetic retinopathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study evaluated differences of TPC and TNF-α concentrations in tears at different severity of NPDR among participants with diabetes in comparison with normal participants.
|
31834153 |
2019 |
|
Heart Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Chronic diseases, like diabetes and heart disease, are considered inflammatory conditions with elevated levels of the proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) and the anti-inflammatory cytokine interleukin-10 (IL-10).
|
31833408 |
2020 |
|
Acute pancreatitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, irisin treatment also effectively downregulated serum tumor necrosis factor-alpha and interleukin-6 levels and alleviated injury in the pancreas, liver and lung of AP mice.
|
31832004 |
2019 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The TNF-α level in AS was significantly lower than that in RA (p = 0.016).
|
31830775 |
2020 |
|
Ankylosing spondylitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The TNF-α level in AS was significantly lower than that in RA (p = 0.016).
|
31830775 |
2020 |
|
Tinnitus
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
TNF-α and HSP70 levels appears to be sensitive to the time when samples were collected (morning or afternoon).<b>Conclusions:</b> The results of our study showing fluctuations in inflammatory markers along the hearing loss process, reinforce the idea that inflammatory mechanisms are involved in hearing loss pathogenesis but also in tinnitus.
|
31829778 |
2019 |
|
Degenerative polyarthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PI3K inhibitor LY294002 attenuated TNF-α-induced overexpression of Cadherin-11 and decreased the invasive capacity of OA FLS.
|
31829201 |
2019 |
|
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study aimed to characterize the activation of Schwann cells (SCs) and the increase of expression of inflammatory cytokines IL-1β, IL-6, and TNF-α in the sural nerve of PD, and further explore whether peripheral nerve inflammation is the cause of PD sensory disturbances.
|
31828965 |
2019 |