Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
The aim of this study was to evaluate the association of genetic variants within the genes encoding tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-3 (MMP-3), with stroke.
|
21219546 |
2011 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We investigated the role of inflammatory genes IL1B, IL6, MPO, and TNF in stroke susceptibility and recovery in a population sample of 672 patients and 530 controls, adjusting for demographic, clinical and lifestyle risk factors, and stroke severity parameters.
|
21407237 |
2011 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Recent reports suggested that tumor necrosis factor-α (TNF-α) (-308) polymorphism is an important risk factor for stroke in children with SCA.
|
21160173 |
2011 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
RGD |
Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns.
|
21171972 |
2010 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
In inflammatory cytokines, increased cytokines [including interleukin (IL) 1beta, IL-18, tumor necrosis factor alpha] after stroke lead to depression.
|
19891854 |
2009 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor- alpha (TNF-alpha), an important immune mediator, may contribute to the initiation and progression in the stroke.
|
19168815 |
2009 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk.
|
17981284 |
2008 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk.
|
17600229 |
2007 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis.
|
17452160 |
2007 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk.
|
17600229 |
2007 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
It was examined whether G to A promoter polymorphism in the tumor necrosis factor-alpha gene at position -308 affects the risk of stroke.
|
16473522 |
2006 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
|
16879054 |
2006 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
|
16879054 |
2006 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We investigated whether gradual increases in tumor necrosis factor-alpha (TNF-alpha) reported during exercise down-regulates expression of TNF-alpha receptors I and II (TNFRI and II) in stroke, leading to reduced brain damage.
|
17109621 |
2006 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
There is increasing evidence on the role of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the occurrence and outcome of stroke.
|
15733973 |
2005 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The combination of TNF (-308)GG homozygosity and the IL4R 503P variant carrier status was associated with a particularly strong predisposition to LV stroke (odds ratio [OR] = 5.5; 95% confidence interval [CI] = 2.3-13.1).
|
14615367 |
2004 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene.
|
15036607 |
2004 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
LHGDN |
The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke.
|
14681891 |
2003 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Cells that are resistant to apoptosis by Par-4 alone, however, are greatly sensitized by Par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, tumor necrosis factor, ionizing radiation, intracellular calcium elevation, or those involved in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and stroke.
|
12565819 |
2003 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Possession of the TNF-alpha T allele significantly increases the risk of vascular dementia, and increases the risk of Alzheimer's disease associated with apolipoprotein E. Although further research is needed, these findings suggest a potential role for anti-inflammatory therapy in vascular dementia and Alzheimer's disease, and perhaps especially in patients who have had a stroke.
|
11273064 |
2001 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
CTD_human |
The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke.
|
10950380 |
2000 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This study was designed to detect wether the TNF2 allele is associated with disease progression in MS. We examined the TNFalpha -308 polymorphism with an allelic discrimination PCR to detect the G-->A transition in the genomic DNA of 283 MS patients from Germany and in 72 patients with amyotrophic lateral sclerosis (ALS) and 66 with stroke from the same genetic background who served as controls.
|
10552245 |
1999 |