Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Injection of lentiviral miR-126-5p improved behavioral outcomes at 3 days after stroke (<i>P</i><0.05). miR-126-3p and -5p overexpression downregulated the expression of proinflammatory cytokines IL-1β and TNF-α and adhesion molecules VCAM-1 and E-selectin, as well as decreased MPO<sup>+</sup> (myeloperoxidase positive) cell numbers at 3 days after ischemia (<i>P</i><0.05). 31822249 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation. 31440125 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Quantitative assessment of stroke outcome was evaluated by measuring infarct volume (by magnetic resonance imaging), cerebral blood flow (by laser speckle imaging), neurological and sensory-motor outcome, and postischemic thrombo-inflammation (platelet thrombi, fibrin, neutrophil, phospho-NFκB [nuclear factor κB], TNFα [tumor necrosis factor α], and IL1β [interleukin 1β]). 30909835 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE <b>Results:</b> MCAo resulted in profound attenuation of immune activation, as anticipated. t-PA treatment not only worsened neurological deficit, but further reduced lymphocyte and monocyte counts in blood, enhanced plasma levels of both IL-10 and TNFα and decreased various conventional DC subsets in the spleen and cLN, consistent with enhanced immunosuppression and systemic inflammation after stroke. 30972077 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Patients with first-in-life stroke were analysed according to: plasma concentration of the following markers on the first day of stroke: interleukin 2 (IL-2) and interleuki 6 (IL-6), S100B, tumor necrosis factor-α (TNF-α), progranulin (GRN), neuron specific enolase (NSE), urokinase-type plasminogen activator (uPA), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), leucocyte and thrombocyte counts; their neurological status on the first day of stroke (NIHSS) and their functional status at 30 days following stroke (mRS). 31356182 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Primary rat neuronal cells were subjected to a 90-minute HBOT treatment at 2.5 absolute atmospheres prior to either tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS) injury to simulate the inflammation-plagued secondary cell death associated with stroke and traumatic brain injury (TBI). 30972972 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE <b>Background:</b> Tumor necrosis factor-a-induced protein 8-like 2 (TIPE2) is a novel regulator of immunity and protects against experimental stroke. 30588195 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE These data provide evidence that serum TNF-α and IL-1β concentrations are related to poor long-term outcomes after stroke in the presence of particular alleles. 29161722 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE The reduced release of TNFα and IP-10 after ex vivo blood stimulation with endotoxin is independently associated with poor outcome after stroke. 29275013 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE We also subjected TNF knockout mice to experimental stroke (permanent middle cerebral artery occlusion) and validated the effect of TNF inhibition on EV release. 29807527 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Alveolar macrophages and epithelial and endothelial cells of Sham and Stroke animals were also isolated for evaluation of mRNA expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α. 30290827 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke. 30120034 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE These findings indicate the important roles that TNF-α and IL-1β serum levels play regarding the risk of PSD, particularly during the acute phase of stroke and in patients with genetic susceptibility. 28844626 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Stroke survivors (50-76 years) underwent a fasting blood draw for measurement of TNF-α, IL-6, CRP, serum amyloid A, sICAM-1, sVCAM-1, and bilateral vastus lateralis biopsies before and after RT. 27955950 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Serum levels of TNF-α, C-reactive protein (CRP), IL-4, IL-6, IL-10, IL-17, IL-23, and TGF-β increased, whereas serum level of IFN-γ decreased at all time points after stroke. 27682880 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE This study suggests that delirium is not scarce in patients with AIS admitted to the non-intensive stroke unit, and that delirium developing after AIS seems not to be associated with serum TNF-alpha, IL-1 beta, IL-18, BDNF and NSE but is associated with length of hospital stay and stroke severity. 27816188 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Quantitative PCR analysis of whole cell lysate as well as flow-sorted myeloid cells from the perilesional cortex showed increased cellular interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) mRNA levels but reduced plasma levels of these cytokines in MS P2X4R KO mice after stroke. 28751018 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Moreover, plasma H19 levels showed a positive correlation with National Institute of Health Stroke Scale score and tumor necrosis factor-α levels. 28630232 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke. 28611085 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor (TNF) has been shown to be involved in the pathogenesis of hemorrhagic stroke, having deleterious effects on cerebral arteries by promoting inflammation and apoptosis in vascular and immune cells. 27809686 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Cumulative incidence of stroke was significantly higher for children with TNF-α A allele (p=0.02) and lower for children with HBA deletion (p=0.02). 25175566 2015
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE TNF-α and PON total methylation levels correlated each other (r = 0.44; p = 0.031), especially in stroke patients (r = 0.72; p = 0.008). 24500802 2014
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Polymorphic variants in genes encoding apoptotic proteins, either from the extrinsic (FAS, TNF-α, CASP8) or the intrinsic (BAX, BCL2, CASP3, CASP9) pathways could be highly valuable in the diagnosis of neurodegenerative diseases and stroke. 22695677 2013
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE These findings strongly implicate the involvement of TNF-α in the pathogenesis of stroke. 23050663 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Up-regulated TNF-α expression has also been found in various neurodegenerative diseases such as cerebral malaria, AIDS dementia, Alzheimer's disease, multiple sclerosis, and stroke, suggesting a potential pathogenic role of TNF-α in these diseases as well. 21298033 2011