|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of the present study was to describe our experience with the recombinant Fab' antibody fragment against TNF-α Certolizumab Pegol (CZP) in patients with Behçet's disease (BD) refractory to standardized therapies and previous biologic agents.
|
28712320 |
2017 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
No differences existed in patients switched from other tumor necrosis factor (TNF)-α inhibitors about efficacy at 12 weeks (p = 0.13) and rapidity of response (p = 0.93) while relapses (p = 0.01) and ADA discontinuation at 24 months (p = 0.001) were significantly more common.Adverse events occurred in 10 patients.ADA confirmed its effectiveness in BD.
|
27679471 |
2017 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The activating transcription factor 3 (ATF3) transcript level was increased in PBMCs from patients with stable BD compared to that in PBMCs from HCs. siRNAs targeting C/EBPβ and C/EBPδ significantly reduced the production of IL-6 and TNF-α in lipopolysaccharide-stimulated CD11b+ cells from patients with BD as well as from HCs.
|
28392644 |
2017 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether single nucleotide polymorphisms (SNPs) of the Tumor Necrosis Factor Superfamily 4 (TNFSF4) gene are associated with Vogt-Koyanagi-Harada (VKH) and Behcet's disease (BD) in a Chinese Han population.
|
27872495 |
2016 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nine BD patients (mean age 34.55 ± 16.30 years) refractory to tumor necrosis factor blockers and standardized therapies are reported in our survey.
|
24305945 |
2015 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-23 Receptor Gene Polymorphism May Enhance Expression of the IL-23 Receptor, IL-17, TNF-α and IL-6 in Behcet's Disease.
|
26222305 |
2015 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study might suggest that TNF-α -308A/G, IL-10 -1082G/A, -819C/T, -592C/A polymorphisms are associated with BD susceptibility.
|
24267724 |
2013 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the meta-analysis showed a significant association of the TNF -857T/C polymorphism with BD (OR = 0.758, 95% CI = 0.593-0.968, p = 0.027).
|
24049437 |
2013 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report the first association between BD and TNF-α SNPs in Moroccan patients.
|
22711844 |
2012 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assayed aqueous humor (AH) samples from patients with Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-γ and tumor necrosis factor-α and the immunosuppressive cytokine IL-10.
|
21334264 |
2011 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Data suggest that other HLA (HLA-C, HLA-DR) and HLA-related [MHC Class I chain-related gene A (MIC-A), TNF-α] genes may play a role in BD co-susceptibility or pathogenesis.
|
21059670 |
2011 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
No apparent differences in interleukin (IL)-4, 6, 8 and 10 were observed, whereas production of soluble IL-2-receptor and tumor necrosis factor (TNF)-alpha were more pronounced in the BD group.
|
21816027 |
2011 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that functional TNF-α, IL10 genotypes or combined TNF-α, IL10 genotypes do not play a role in BS susceptibility in Turkish BS patients.
|
20191386 |
2010 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Particular genotypes and haplotypes in TNF-α were over-represented in BD, which may, in turn, predispose individuals to this disease.
|
21059493 |
2010 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A literature review was performed using MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials for original studies published in English up to October 31, 2009 and that examined the association of the TNF-alpha promoter polymorphisms with Behçet's disease.
|
20470944 |
2010 |
|
Behcet Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since NRAMP1 plays a role in the up-regulation of the TNF-alpha, iNOS and MHC expression, it may also be a candidate gene for Behçet's syndrome (BS).
|
18998137 |
2009 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphisms of the IL-6 and IL-8 receptor genes and the TNF-alpha gene analysed here do not appear to be associated with Behçet's disease.
|
19026125 |
2009 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that TNF-alpha is a susceptibility gene for BD in patients from Iranian Azeri Turk ethnic group.
|
19774383 |
2009 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also sought to determine the effects of periodontal condition and TNF-alpha-1031T/C polymorphism on clinical severity of BD.
|
18355201 |
2008 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the TNF molecule may have an important genetically and/or functionally implication in the pathogenesis of BD in the Tunisian population.
|
17349875 |
2007 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
The aim of the study is to compare stimulated production of TNF-alpha by PBM of BD patients with that of healthy volunteers (HV) and to examine correlations between the ability of PBM to produce TNF-alpha and organ/system involvement in patients with BD.
|
16897113 |
2007 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with the novel -646A allele of the TNFalpha promoter region were significantly associated with the expression of the HLA-B51 allele (p(corr) = 0.006), although this novel polymorphic allele was not associated with BD susceptibility.
|
17657677 |
2007 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Six polymorphisms in the promoter region of TNFA were genotyped in 254 BD patients and 344 control subjects, via the PCR-RFLP technique.
|
16891799 |
2006 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of TNFA promoter region haplotype in Behçet's Disease.
|
16891799 |
2006 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relation of the TNF-alpha-1031 T/C polymorphism with susceptibility to BD in a Turkish population and to determine the functional importance of this polymorphism.
|
16882174 |
2006 |