|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic association study of tumor necrosis factor-alpha with sepsis and septic shock in Thai pediatric patients.
|
23033000 |
2013 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genotypes of TNF-β and the production of TNF-α were related to the occurrence of sepsis.
|
24796628 |
2014 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, results showed that pretreatment with rapamycin reduced the pyroptosis of peritoneal macrophages stimulated by cecal contents and the release of inflammatory factors such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α); In septic mice, rapamycin treatment decreased the activation of inflammasome in lung, and alleviated the pathological injuries in lung, liver and spleen tissues during acute stage of sepsis.
|
31174699 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that IL-1β production during sepsis with uropathogenic <i>E. coli</i> is mediated by caspase-8, since caspase-8 and RIPK3 double knock out mice show substantially lower cytokine during sepsis and increased survival after injection of TNFα.
|
28428949 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-<i>α</i> and IL-1<i>β</i> in peritoneal lavage fluid of mice with sepsis.
|
30538802 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Honokiol Increases CD4+ T Cell Activation and Decreases TNF but Fails to Improve Survival Following Sepsis.
|
29023360 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, no significant association was found between TNF-α -308G/A and -238G/A polymorphisms and sepsis-related mortality.
|
28294408 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the apparent protective effect of the tumor necrosis factor B1B1 genotype on the development of severe encephalopathy may be related to the effects of this genotype on tumor necrosis factor-alpha production in sepsis.
|
9696492 |
1998 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-27 was elevated in sepsis patients with acute hepatic injury, which correlated with the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHEII) scores, Sequential Organ Failure Assessment (SOFA) scores, and procalcitonin, C-reactive protein, IL-6, and TNF-α expression.
|
31786500 |
2020 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-38 administration decreased the inflammatory response, as reflected by lower levels of cytokines and chemokines (including IL-6, TNF-α, interleukin 10, interleukin 17, interleukin 27, CXCL1, and CCL2), and less damage to tissues (including lung, liver, and kidney) in CLP-induced sepsis.
|
29762676 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Impaired TNF-α production as a marker of sepsis-associated innate immune dysfunction may be a feasible target for immune stimulation to decrease time to organ failure recovery.
|
28372498 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, 20 patients with post-surgical inflammation, 20 patients with sepsis or septic shock were included and TNFα was determined following ex vivo stimulation of whole blood with 500 pg/mL LPS.
|
28771573 |
2017 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, rTM administered prior to or after LPS suppressed the level of pro-inflammatory cytokine TNF-α in sera at 1-3 h after LPS injection, whereas only the administration of rTM after LPS suppressed the levels of HMGB1 and nucleosome (late-phase mediators of sepsis) (9-12 h) in sera after the LPS injection.
|
28587368 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, in this pilot study the biallelic Ncol polymorphism within the TNF locus was not a prognostic marker for disease progression in high-risk NICU-admitted term and preterm infants with culture-proven sepsis.
|
10782394 |
2000 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study may indicate that TNF-alpha-308G/A and IL-10-592C/A polymorphisms involved in subsequent activation of cytokine network had a larger effect on clinical outcome in patients with sepsis than TLR4Asp299Gly, Thr399Ile, and CD14-159C/T polymorphisms associated with the initial host-microbial interaction.
|
16051275 |
2005 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In critically ill patients with sepsis induced AKI, serum TNF-α and uNAG measured at admission can predict severity of sepsis and AKI (defined by REFILE) occurrence along with pre-existing CKD and DM.
|
29978383 |
2018 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, this work provides the first in vivo evidence that administering BMMSCs or UCMSCs to rats with CLP-induced sepsis could increase circulating CD3+CD4+CD25+ Treg cells and Treg cells/T cells ratio, enhance Treg cell suppressive function, and decrease serum levels of interleukin-6 and tumor necrosis factor-α, suggesting the immunomodulatory association of Treg cells and MSCs during sepsis.
|
25337817 |
2014 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, a cell model of sepsis, comprising lipopolysaccharide (LPS)‑tolerant THP‑1 cells, was used to investigate whether the SirT1 activator, resveratrol, repressed the transcription of TNF‑α.
|
27878240 |
2016 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis.
|
26025100 |
2015 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study we analyzed the impact of PLD1 in the regulation of TNF-α, inflammation and organ damage in experimental sepsis.
|
29968773 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, the relationship between the TNF-alpha 308G/A, the IL-6-174 G/C, the PAI-1, the FVL, the EPCR, and the Cathepsin G (Ars 125 Ser) polymorphisms and the development and outcome of sepsis in pediatric patients was studied.
|
16444434 |
2006 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vivo Lipopolysaccharide Tolerance Recruits CD11b+ Macrophages to the Liver with Enhanced Bactericidal Activity and Low Tumor Necrosis Factor-Releasing Capability, Resulting in Drastic Resistance to Lethal Septicemia.
|
28675904 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vivo, IAL reduced the secretion of IL-6 and TNF-α in serum, and increased the survival rate of mice with LPS-induced sepsis.
|
28407580 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increase in cytokines such as IL-6, Il-8, IL-10, IL-18 and TNF-α may have implications in diagnosis and treatment of sepsis.
|
24292568 |
2014 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased levels of TNF-α in sepsis sera do not explain diminished keratinocyte migration.
|
28086962 |
2017 |