|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The whole peripheral blood samples obtained immediately after admission were stimulated with bacterial lipopolysaccharide and then determined for production of tumor necrosis factor α. Sepsis morbidity rate and multiple organ dysfunction (MOD) scores were accessed.
|
22266968 |
2012 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genotypes of TNF-β and the production of TNF-α were related to the occurrence of sepsis.
|
24796628 |
2014 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study we analyzed the impact of PLD1 in the regulation of TNF-α, inflammation and organ damage in experimental sepsis.
|
29968773 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared with healthy children, children with sepsis demonstrated lower LPS-induced TNF-α production (P < 0.0001) and lower phytohemagglutinin-induced IFN-γ production (P < 0.0001).
|
29470918 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because TNF-α is a major mediator of the pathophysiology of sepsis and blocking inflammation is a possible line of therapy in such circumstances, we tested the efficacy of rPPE18 in reducing symptoms of sepsis in a mouse model of <i>Escherichia coli-</i>induced septic peritonitis. rPPE18 significantly decreased levels of serum TNF-α, IL-1β, IL-6, and IL-12 and reduced organ damage in mice injected i.p. with high doses of <i>E. coli</i> Peritoneal cells isolated from rPPE18-treated mice had characteristics of M2 macrophages which are protective in excessive inflammation.
|
29669785 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lethality from sepsis is believed to be mediated by a proinflammatory cytokine cascade, yet blocking the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) fails to prevent mortality in human disease and a mouse model of sepsis induced by cecal ligation and puncture (CLP).
|
12117955 |
2002 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis.
|
8741040 |
1996 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of 24 h delayed normobaric oxygen (NBO<sub>2</sub>) and HBO<sub>2</sub> treatment on the endogenous production of the inflammatory markers interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-10, and on mortality in rats with cecal ligation and puncture (CLP) induced sepsis.
|
29204105 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Single Nucleotide Polymorphisms (SNPs) at positions -238, -308, -376 and +489 in the promoter region of TNF gene exhibit differential association to inflammation and increased TNF production in sepsis.
|
23317877 |
2013 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevated levels of PCT, IL-6, IL-8, IL-10, and TNFα were observed in most patients with sepsis and DIC.
|
30991817 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study will provide high-quality synthesis of current evidence of QWBDD in the treatment of sepsis from the following aspects, including 28-day mortality, mean arterial pressure (MAP), blood lactate, procalcitonin (PCT), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), acute physiology and chronic health score (APACHE-II), intensive care unit stay, mean hospital stay, mechanical ventilation time, etc.
|
30817635 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Based on LPS induced sepsis model for the measurement of TNF-α inhibition in Swiss Albino mice and neutrophilia inhibition for asthma and COPD in Sprague Dawley rats with the potential molecules, compound 4 m would be great promise as a hit inhibitor in the future study.
|
30131242 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor alpha as a central mediator of the inflammation cascade is correlated to sepsis outcome.
|
15187748 |
2004 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review explores some of the new elements of immunoinflammatory response in severe sepsis, tumor necrosis factor-alpha in severe acute pancreatitis as a clinical example of immune response in sepsis, immune response in severe trauma with or without secondary sepsis, and genetic aspects of host immuno-inflammatory response to various insults in critically ill patients.
|
24371374 |
2013 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The amount of TNF released in situations of severe infection and sepsis appears to be influenced genetically.
|
8625623 |
1996 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF) is recognized as a central mediator of sepsis, septic shock, and multiple organ failure.
|
8832971 |
1997 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Honokiol Increases CD4+ T Cell Activation and Decreases TNF but Fails to Improve Survival Following Sepsis.
|
29023360 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Toll-like receptors (TLR) recognize pathogens and trigger the production of vigorous pro-inflammatory cytokines [such as tumour necrosis factor (TNF)] that induce systemic damages associated with sepsis and chronic inflammation.
|
24758719 |
2014 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increase in cytokines such as IL-6, Il-8, IL-10, IL-18 and TNF-α may have implications in diagnosis and treatment of sepsis.
|
24292568 |
2014 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Key mediators of pathologic sequelae of sepsis in the brain include cytokines, including TNF-α, and sphingolipids, which are biologically active components of cellular membranes that possess diverse functions.
|
28670310 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Whereas it is known that BA metabolism is dysregulated in sepsis and related conditions, we have shown that T cells are able to control the synthesis and metabolism of BAs, a process which depends on TNF and IFN-γ.
|
31207266 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Antibodies to ubiquitin were able to (1) significantly increase (2- to 5-fold) the TNF-alpha response to endotoxin in whole blood from trauma and sepsis patients, (2) completely neutralize the inhibitory effect of trauma patients' serum on healthy donors' TNF-alpha production, and (3) partially neutralize the inhibitory effect of sepsis patients' serum on healthy donors' TNF-alpha production.
|
12406900 |
2003 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Impaired TNF-α production as a marker of sepsis-associated innate immune dysfunction may be a feasible target for immune stimulation to decrease time to organ failure recovery.
|
28372498 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Blood urea nitrogen, creatinine, plasma neutrophil gelatinase-associated lipocalin, interleukin-6, interleukin-10, and tumor necrosis factor-α were markedly increased in the H d-gal group after establishment of the sepsis model (H d-gal vs control, <i>P</i><0.05 at 12 h and 24 h post-CLP).
|
28408808 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
It has been shown that Fas, Fas-L, TNF and TNFR-1 display high serum concentrations in subjects with sepsis.
|
28144786 |
2017 |