Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We assessed the hypothesis that there is a relationship between the p53 codon 72, Pro/Pro polymorphism, cumulative arsenic exposure, and the risk of skin cancer in a hospital-based case-control study in southwestern Taiwan.
|
12635827 |
2003 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Because p53 tumor suppressor protein is a protective cellular molecule against environmental carcinogens and mutations in the p53 gene are frequent in nonmelanoma skin cancers, we studied p53 in 23 premalignant or malignant skin lesions from seven patients with a history of arsenic medication.
|
10223623 |
1998 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer.
|
8128225 |
1994 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Alteration of the p53 gene is the most frequent event reported in human cancer, and p53 mutations have been observed in various neoplasms, including certain forms of skin cancer.
|
9261472 |
1997 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that the alterations in the critical binding region of the p53 gene are infrequent in rat skin cancers induced by either electron or neon ion radiation.
|
8625503 |
1996 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The MDM2 oncogene negatively regulates p53 protein levels, and both genes have functional polymorphisms that may modify skin cancer risk.
|
21123835 |
2011 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This clonal expansion of mutant p53 may provide a molecular basis for high risk of developing subsequent new skin cancers in patients with BCC.
|
7769260 |
1995 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ultraviolet-light induced p53 mutational spectrum in yeast is indistinguishable from p53 mutations in human skin cancer.
|
9635858 |
1998 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Characteristic p53 mutation spectra have been associated with dietary aflatoxin B(1) (AFB(1)) exposure and hepatocellular carcinoma (HCC); sunlight exposure and skin cancer; and cigarette smoking and lung cancer.
|
10767641 |
2000 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
UVB irradiation is known to produce DNA damage at mutation hotspots in the p53 tumor suppressor gene, leading to the development of skin cancers.
|
11174390 |
2001 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
USA, in press, 1993) report such a strand bias of p53 mutation in skin cancers from XP-C patients.
|
8221675 |
1993 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A new study shows that UV-damaged DNA is deaminated during transcription, which is a probable mechanism underlying CC tandem mutations found in the p53 gene in skin cancers.
|
20129038 |
2010 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Secondly, we detected mutations both in p53 and ras of skin cancers from patients with xeroderma pigmentosum (XP).
|
10764991 |
2000 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have measured deamination events in the human p53 gene, which contains a large percentage of C to T transitions in skin cancers.
|
9813119 |
1998 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer.
|
8336934 |
1993 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
About 40-50% of all skin cancers in normal individuals and 60-80% of the DNA-repair-deficient xeroderma pigmentosum patients exhibit p53 mutations.
|
12444960 |
2002 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Spontaneous skin cancer-like tumors were detected in about 25% of RKTG nullizygous and p53 heterozygous mice within 7 months of age.
|
21385899 |
2011 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We assessed the association of the p53 codon 72 polymorphism with tanning response, and its interaction with MC1R variants on tanning response and skin cancer risk.
|
18510673 |
2008 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
|
8483937 |
1993 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A different molecular signature in the p53 gene is found in skin cancer caused by sunlight.
|
8781359 |
1996 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Hence, EMAST likely reflects a particular pattern of somatic events that are interactive with p53 mutation, particularly common in skin cancer and limited to non-invasive disease in bladder cancer.
|
12118368 |
2002 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The presence of a characteristic p53 mutation also can manifest a molecular link between exposure to a particular carcinogen and a specific type of human cancer, e.g. aflatoxin B1 (AFB1) exposure and codon 249ser mutations in hepatocellular carcinoma, ultraviolet (UV) exposure and CC to TT tandem mutations in skin cancer, and cigarette smoke and the prevalence of G to T transversions in lung cancer.
|
11720736 |
2001 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additionally, we show that, following exposure to UV-B radiation, XPC p53 mutant mice have more severe solar keratosis and suffer accelerated skin cancer compared with XPC mutant mice that are wild-type with respect to p53.
|
8994835 |
1996 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
UV-related mutations of the p53 gene have been identified in human skin cancers.
|
8030743 |
1994 |
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Microdissection would increase the detection rate of the p53 gene mutations and LOH not only in skin cancer but also in precancerous lesions.
|
10940505 |
2000 |