|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Skin cancer predisposition is significantly augmented when mice are additionally defective in Trp53 (p53) gene function.
|
10725660 |
2000 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A different molecular signature in the p53 gene is found in skin cancer caused by sunlight.
|
8781359 |
1996 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A dysfunction of the p53 gene is thus likely to play a part in epidermodysplasia verruciformis carcinogenesis, either due to ultraviolet-B-induced p53 mutations, as in nonmelanoma skin cancers in the general population, or involving other mutagens or mechanisms.
|
11676835 |
2001 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A new study shows that UV-damaged DNA is deaminated during transcription, which is a probable mechanism underlying CC tandem mutations found in the p53 gene in skin cancers.
|
20129038 |
2010 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.
|
1946433 |
1991 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
About 40-50% of all skin cancers in normal individuals and 60-80% of the DNA-repair-deficient xeroderma pigmentosum patients exhibit p53 mutations.
|
12444960 |
2002 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additionally, we show that, following exposure to UV-B radiation, XPC p53 mutant mice have more severe solar keratosis and suffer accelerated skin cancer compared with XPC mutant mice that are wild-type with respect to p53.
|
8994835 |
1996 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Alteration of the p53 gene is the most frequent event reported in human cancer, and p53 mutations have been observed in various neoplasms, including certain forms of skin cancer.
|
9261472 |
1997 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although mammalian solar UV-induced mutation spectra were studied intensively in the aprt gene using rodent cultured cells and the UV-specific mutation pattern was confirmed, the second characteristic of the p53 mutations in human skin cancers had not been reproduced.
|
16620158 |
2007 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
An early event in skin cancer is the mutation of a single p53 allele.
|
25789975 |
2015 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Analysis of skin cancer risk factors in immunosuppressed renal transplant patients shows high levels of UV-specific tandem CC to TT mutations of the p53 gene.
|
17065198 |
2007 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of p53 arginine polymorphism with skin cancer.
|
15230885 |
2004 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
bcl-2 vs p53 protein expression and apoptotic rate in human nonmelanoma skin cancers.
|
9158413 |
1997 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Because p53 tumor suppressor protein is a protective cellular molecule against environmental carcinogens and mutations in the p53 gene are frequent in nonmelanoma skin cancers, we studied p53 in 23 premalignant or malignant skin lesions from seven patients with a history of arsenic medication.
|
10223623 |
1998 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because ultraviolet light can induce specific p53 mutations and is linked to the development of skin cancers, this study was done to determine the significance of p53 protein (p53p) overexpression in melanomas originating at different cutaneous sites varying in frequency of sunlight exposure.
|
9445187 |
1998 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
C/EBPβ Suppresses Keratinocyte Autonomous Type 1 IFN Response and p53 to Increase Cell Survival and Susceptibility to UVB-induced Skin Cancer.
|
30698678 |
2019 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Characteristic p53 mutation spectra have been associated with dietary aflatoxin B(1) (AFB(1)) exposure and hepatocellular carcinoma (HCC); sunlight exposure and skin cancer; and cigarette smoking and lung cancer.
|
10767641 |
2000 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
Current evidence suggests that p53 accumulation is critical to the development of skin cancer in the general population.
|
10037511 |
1999 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
DNA preparations from 2 cm(2) sections of chronically irradiated Hupki epidermis harbor C to T and CC to TT mutations at two mutation hotspots identified in human skin cancer, one at codons 278-279, and one at codons 247-248; the latter is the most frequent UVB-associated mutation site in humans but not in p53 wild-type mice.
|
11719445 |
2001 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression of p53 by keratinocytes may be important in the pathogenesis of skin cancer induced by ultraviolet light.
|
29664771 |
2018 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For example, the p53 mutational spectrum reveals evidence for a direct causal effect of ultraviolet radiation in skin cancer, of aflatoxin B1 in liver cancer, and of tobacco smoke in lung cancer.
|
10612830 |
2000 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic alterations within the p53 gene have been shown to have a direct correlation with cancer development and have been shown to occur in nearly 50% of all cancers. p53 mutations are particularly common in skin cancers and UV irradiation has been shown to be a primary cause of specific 'signature' mutations that can result in oncogenic transformation.
|
17270229 |
2007 |
|
Malignant neoplasm of skin
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Hence, EMAST likely reflects a particular pattern of somatic events that are interactive with p53 mutation, particularly common in skin cancer and limited to non-invasive disease in bladder cancer.
|
12118368 |
2002 |
|
Malignant neoplasm of skin
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Here the authors describe an immunohistochemical study to evaluate the expression of p53 in benign and malignant skin lesions from renal transplant recipients and immunocompetent patients with skin cancer.
|
11552722 |
2001 |
|
Malignant neoplasm of skin
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the relationship between Tp53 and cutaneous HPV infection is not well understood in skin cancers.
|
22545084 |
2012 |