Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, focusing on MUC5B may provide a unique opportunity to define the early molecular events that lead to, and potentially prevent, the development of IPF.
|
30431344 |
2018 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
A common MUC5B promoter polymorphism and pulmonary fibrosis.
|
21506741 |
2011 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
To determine whether single-nucleotide polymorphisms (SNPs) within TOLLIP and MUC5B modify the effect of interventions in subjects participating in the Evaluating the Effectiveness of Prednisone, Azathioprine, and N-Acetylcysteine in Patients with Idiopathic Pulmonary Fibrosis (PANTHER-IPF) clinical trial.
|
26331942 |
2015 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel genome-wide significant signal of association with IPF susceptibility near A-kinase anchoring protein 13 (AKAP13; rs62025270, odds ratio [OR] 1·27 [95% CI 1·18-1·37], p=1·32 × 10<sup>-9</sup>) and confirmed previously reported signals, including in mucin 5B (MUC5B; rs35705950, OR 2·89 [2·56-3·26], p=1·12 × 10<sup>-66</sup>) and desmoplakin (DSP; rs2076295, OR 1·44 [1·35-1·54], p=7·81 × 10<sup>-28</sup>).
|
29066090 |
2017 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, patients with the MUC5B polymorphism show more severe coughing as MUC5B encodes for the dominant mucin in the honeycomb cysts of IPF patients.
|
30269188 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
MUC5B promoter rs868903 polymorphism and TLs were associated with radiographic extent and survival in a Chinese IPF cohort.
|
31653936 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, genetic variants of TOLLIP, MUC-5B, and other genes associated with a differential response to treatment and with the development and/or the prognosis of IPF are reported.
|
30526140 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Secreted mucins (MUC2, MUC5AC, MUC5B, MUC6-8 and MUC19) are released to the extracellular medium and recent evidence has shown that a promoter polymorphism in the secreted mucin MUC5B is associated with IPF risk.
|
31514468 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
|
23583980 |
2013 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The MUC5B promoter SNP rs35705950 was associated with IPF in the Mexican (OR = 7.36, P = .0001), but not the Korean (P = .99) cohort.
|
25275363 |
2015 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A common variant in mucin 5B predisposes to both familial and sporadic IPF and is present in the majority of cases, indicating sporadic IPF occurs in those with genetic predisposition.
|
23020878 |
2013 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis.
|
25581455 |
2015 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Associations between 2 polymorphisms in TERT (rs2736100) and MUC5B (rs35705950) and IPF or non-IPF sporadic ILD were tested using 227 patients with ILD and 689 control subjects.
|
24434656 |
2014 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A promoter variant in MUC5B, rs35705950, was previously found to be strongly associated with the incidence of idiopathic pulmonary fibrosis (IPF) and also the overall survival (OS) of such patients.
|
28189065 |
2017 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirm the MUC5B variant association with IPF.
|
23321605 |
2013 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Baseline bacterial burden predicted the rate of decline in lung volume and risk of death and associated independently with the rs35705950 polymorphism of the MUC5B mucin gene, a proven host susceptibility factor for IPF.
|
25184687 |
2014 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of MUC5B is also highly correlated with expression of cilium genes in IPF lung.
|
26595739 |
2015 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
A common MUC5B promoter polymorphism and pulmonary fibrosis.
|
21506741 |
2011 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, genetic variants of TOLLIP, MUC5B, and other genes are associated with a differential response to treatment and with the development and/or the prognosis of IPF.
|
29408012 |
2018 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with IPF.
|
30560893 |
2018 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis.
|
28272906 |
2017 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The MUC5B promoter polymorphism was recently found to markedly elevate risk for IPF, though a particular association with NSIP has not been previously reported, nor has its contribution to disease risk previously been evaluated in the genome-wide context of all genetic variants.
|
25192356 |
2014 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In spIPF carriership of MUC5B minor allele did not influence survival.
|
26699835 |
2016 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A common promoter polymorphism (rs35705950) in MUC5B, the gene encoding mucin 5B, is associated with idiopathic pulmonary fibrosis.
|
23692170 |
2013 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Similarly, recent genetic studies have demonstrated strong and replicable associations between a common promoter polymorphism in the mucin 5B gene (MUC5B) and both IPF and the presence of abnormal imaging findings in the general population.
|
24547893 |
2014 |