Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, focusing on MUC5B may provide a unique opportunity to define the early molecular events that lead to, and potentially prevent, the development of IPF.
|
30431344 |
2018 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
To determine whether single-nucleotide polymorphisms (SNPs) within TOLLIP and MUC5B modify the effect of interventions in subjects participating in the Evaluating the Effectiveness of Prednisone, Azathioprine, and N-Acetylcysteine in Patients with Idiopathic Pulmonary Fibrosis (PANTHER-IPF) clinical trial.
|
26331942 |
2015 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel genome-wide significant signal of association with IPF susceptibility near A-kinase anchoring protein 13 (AKAP13; rs62025270, odds ratio [OR] 1·27 [95% CI 1·18-1·37], p=1·32 × 10<sup>-9</sup>) and confirmed previously reported signals, including in mucin 5B (MUC5B; rs35705950, OR 2·89 [2·56-3·26], p=1·12 × 10<sup>-66</sup>) and desmoplakin (DSP; rs2076295, OR 1·44 [1·35-1·54], p=7·81 × 10<sup>-28</sup>).
|
29066090 |
2017 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, patients with the MUC5B polymorphism show more severe coughing as MUC5B encodes for the dominant mucin in the honeycomb cysts of IPF patients.
|
30269188 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
MUC5B promoter rs868903 polymorphism and TLs were associated with radiographic extent and survival in a Chinese IPF cohort.
|
31653936 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, genetic variants of TOLLIP, MUC-5B, and other genes associated with a differential response to treatment and with the development and/or the prognosis of IPF are reported.
|
30526140 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Secreted mucins (MUC2, MUC5AC, MUC5B, MUC6-8 and MUC19) are released to the extracellular medium and recent evidence has shown that a promoter polymorphism in the secreted mucin MUC5B is associated with IPF risk.
|
31514468 |
2019 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The MUC5B promoter SNP rs35705950 was associated with IPF in the Mexican (OR = 7.36, P = .0001), but not the Korean (P = .99) cohort.
|
25275363 |
2015 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A common variant in mucin 5B predisposes to both familial and sporadic IPF and is present in the majority of cases, indicating sporadic IPF occurs in those with genetic predisposition.
|
23020878 |
2013 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis.
|
25581455 |
2015 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Associations between 2 polymorphisms in TERT (rs2736100) and MUC5B (rs35705950) and IPF or non-IPF sporadic ILD were tested using 227 patients with ILD and 689 control subjects.
|
24434656 |
2014 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A promoter variant in MUC5B, rs35705950, was previously found to be strongly associated with the incidence of idiopathic pulmonary fibrosis (IPF) and also the overall survival (OS) of such patients.
|
28189065 |
2017 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirm the MUC5B variant association with IPF.
|
23321605 |
2013 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Baseline bacterial burden predicted the rate of decline in lung volume and risk of death and associated independently with the rs35705950 polymorphism of the MUC5B mucin gene, a proven host susceptibility factor for IPF.
|
25184687 |
2014 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of MUC5B is also highly correlated with expression of cilium genes in IPF lung.
|
26595739 |
2015 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, genetic variants of TOLLIP, MUC5B, and other genes are associated with a differential response to treatment and with the development and/or the prognosis of IPF.
|
29408012 |
2018 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with IPF.
|
30560893 |
2018 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis.
|
28272906 |
2017 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The MUC5B promoter polymorphism was recently found to markedly elevate risk for IPF, though a particular association with NSIP has not been previously reported, nor has its contribution to disease risk previously been evaluated in the genome-wide context of all genetic variants.
|
25192356 |
2014 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In spIPF carriership of MUC5B minor allele did not influence survival.
|
26699835 |
2016 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A common promoter polymorphism (rs35705950) in MUC5B, the gene encoding mucin 5B, is associated with idiopathic pulmonary fibrosis.
|
23692170 |
2013 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Similarly, recent genetic studies have demonstrated strong and replicable associations between a common promoter polymorphism in the mucin 5B gene (MUC5B) and both IPF and the presence of abnormal imaging findings in the general population.
|
24547893 |
2014 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the MUC5B promoter in the first 142 patients of the French national prospective cohort of IPF, in 981 French patients with SSc (346 ILD), 598 Italian patients with SSc (207 ILD), 1383 French controls and 494 Italian controls.
|
23940607 |
2013 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found that the MUC5B promoter variant was associated with RA-ILD and more specifically associated with evidence of usual interstitial pneumonia on imaging.
|
30345907 |
2018 |
Idiopathic Pulmonary Fibrosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The variation of G>T in the MUC5B promoter (rs35705950) has been associated with idiopathic pulmonary fibrosis (IPF) and familial interstitial pneumonia (FIP) in Caucasians, but no information is available regarding this variant in the Chinese population.
|
25121989 |
2014 |