|
Acute asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.
|
28716644 |
2017 |
|
Acute otitis media
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesize that MEEs containing MUC5B will exhibit a microbiome largely devoid of typical acute otitis media bacteria.
|
28027286 |
2017 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The present study suggested that the combination of MUC5B and TTF-1 expression is useful for discriminating adenocarcinomas from squamous cell carcinomas, yielding prognostic significance in patients with lung adenocarcinoma.
|
25733373 |
2015 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Adenocarcinomas in FOXM1 transgenic mice expressed increased MUC5B and MUC5AC, and reduced NKX2.1, which are characteristics of mucinous adenocarcinomas.
|
29267283 |
2017 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
MUC5AC and MUC5B expression is related to mucus formation in adenocarcinomas.
|
11578957 |
2001 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Colon adenocarcinoma cell lines varied in MUC2 expression levels, and one colon adenocarcinoma cell line, HT-29, had higher levels of MUC5 than MUC2.
|
7946402 |
1994 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
AGR2 preferentially engages with MUC-5 as a primary client and is coexpressed with the acidic mucin in Barrett's esophagus and esophageal adenocarcinoma tissue.
|
31436131 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Previous studies in our laboratory have demonstrated that MUC5B is expressed in human lung adenocarcinomas and during lung morphogenesis.
|
21126317 |
2011 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The high expression of MUC5B was significantly associated with poor outcomes in lung adenocarcinoma.
|
29670111 |
2018 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
The cases were stained for: beta-catenin, c-myc, glutathione synthase kinase (GSK), E-cadherin, cyclin D1, and adenomatous polyposis coli (APC), and MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B and MUC6, using standard immunohistochemistry.
|
17676483 |
2007 |
|
airway disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Symptoms were monitored, and nasal lavages were analysed for MUC5AC and MUC5B, i.e. specific mucins associated with airway diseases.
|
21981454 |
2011 |
|
airway disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
We therefore conclude that this newly cloned mouse Muc5b gene could be used as a marker for studying aberrant mucin gene expression in mouse models of various airway diseases.
|
11587997 |
2001 |
|
airway disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
Mucus hypersecretion with elevated MUC5B mucin production is a pathologic feature in many airway diseases associated with oxidative stress.
|
18757307 |
2009 |
|
Anaplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Disorganisation of the basal lamina observed in patients with Sjögren syndrome may lead to dedifferentiation of acinar mucous cells and, as a consequence, alter sulfation of MUC5B.
|
17998215 |
2008 |
|
Anthracosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first report showing an association between the MUC5B rs2672794 polymorphism and CWP, and our results suggest that MUC5B rs2672794 CC genotype could increase the risk of CWP.
|
24924948 |
2014 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We quantified the principal airway mucins MUC5AC and MUC5B in the sputum of age-matched children with acute and stable asthma and healthy control subjects by using Western blotting.
|
28716644 |
2017 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Accordingly, knowledge of MUC5B structure and its interactions with itself and other proteins is critical to better understand airway mucus biology and improve the management of lung diseases such as asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD).
|
31570524 |
2019 |
|
Asthma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Herein, we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma.
|
29186064 |
2017 |
|
Asthma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In addition, Muc5 expression and goblet cells were significantly decreased in the lung tissue of asthma model mice treated with TLR7a plus Der f 1.
|
28559967 |
2017 |
|
Ataxia Telangiectasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
At w12, steroids decreased MUC5AC (from 40 to 5) and MUC5B (from 45 to 2.5) in NP-ATA patients' epithelium and glands, respectively, compared with baseline.
|
18547287 |
2008 |
|
Autoimmune inflammation of skeletal muscle
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Exploration of the MUC5B promoter variant and ILD risk in patients with autoimmune myositis.
|
29206633 |
2017 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
MUC5AC mucin leads to pathological plugging of the airways whereas MUC5B has a protective role against bacterial infection.
|
31678518 |
2020 |
|
Barrett Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
AGR2 preferentially engages with MUC-5 as a primary client and is coexpressed with the acidic mucin in Barrett's esophagus and esophageal adenocarcinoma tissue.
|
31436131 |
2019 |
|
Bladder Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This observation suggests that the long rare MUC5B-MS6 alleles evaluated in this study could be used to identify the risk of bladder cancer.
|
19191526 |
2009 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We compared the prognostic significance of cytokeratin 19 (CK19), carcinoembryonic antigen (CEA), mammaglobin (MG) and the mucin MUC5B mRNA in bone marrow aspirates in the follow-up of 80 operable breast cancer patients.
|
16012742 |
2005 |