Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Even though UBA1 or UBA7, the early enzymes involved in protein ubiquitination and ubiquitin-like regulation of target proteins, did not underlie the exposure-related deregulation of ubiquitination, a difference was detected in the UBA1 and UBA7 levels between squamous cell carcinomas and respective normal lung tissue (p = 0.02 and p = 0.01) without regard to exposure status.
|
19014429 |
2008 |
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
Biomarker
|
disease |
BEFREE |
In contrast, the proteasomal inhibitor, N-acetyl-leucinyl-leucinyl-norleucinal, inhibited both UBE1L- and RA-mediated PML/RARalpha degradation.
|
18413804 |
2008 |
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
Biomarker
|
disease |
BEFREE |
We previously identified the ubiquitin-activating enzyme-E1-like protein (UBE1L) as an RA-regulated target gene in APL that triggers PML/RARalpha degradation and apoptosis.
|
14976209 |
2004 |
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Notably, retroviral expression of UBE1L rapidly induced apoptosis in NB4 APL cells, but not in cells lacking PML/RARalpha expression.
|
11891284 |
2002 |
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
Carcinoma of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-α through p38 MAPK and JNK signaling pathways in human lung carcinoma.
|
31428903 |
2019 |
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
LHGDN |
Notably, retroviral expression of UBE1L rapidly induced apoptosis in NB4 APL cells, but not in cells lacking PML/RARalpha expression.
|
11891284 |
2002 |
Acute Promyelocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
RA treatment of APL and other RA-responsive leukemic cells induced expression of UBE1L and ISG15 as well as intracellular ISG15 conjugates.
|
14976209 |
2004 |
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
|
11891284 |
2002 |
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
These upregulated genes, including serine/arginine-rich splicing factors (SRSFs; such as <i>SRSF2</i>, <i>SRSF5</i>, <i>SRSF7</i>, and <i>SRSF8</i>) that are associated with messenger RNA splicing and export, and ubiquitin conjugating enzyme E2 (UBE2) members (such as <i>UBE2D2</i>, <i>UBE2G2</i>, <i>UBE2J1</i>, and <i>UBE2E1</i>) that are crucial for protein ubiquitination and protein processing in endoplasmic reticulum (ER), were identified as negative prognostic biomarkers of PCa, as the high expression of them correlated with poor overall survival of PCa patients.
|
31841638 |
2019 |
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Upregulated genes, including serine/arginine-rich splicing factors (SRSFs; such as SRSF2, SRSF5, SRSF7 and SRSF8), and ubiquitin conjugating enzyme E2 (UBE2) members (such as UBE2D2, UBE2G2, UBE2J1 and UBE2E1), were identified as negative prognostic biomarkers of PCa, as the high expression of them correlated with poor overall survival of PCa patients.
|
31563279 |
2019 |
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The effects of ISGylation on HCV were independent of upstream IFN signalling: IFN-alpha-induced ISG expression was not altered by Ube1L knockdown.
|
19846672 |
2010 |
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that shRNA knock-down of expression of ISG15 and UBA7 increased the titers of RABV in neuroblastoma cell line NA and microglial cell line BV-2 cells and shRNA knockdown of ISG15 conjugation alleviates the IFN-induced inhibition of RABV gene expression in vitro.
|
29056542 |
2017 |
Rabies (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
To our knowledge, we for the first time documented the anti-RABV function of ISG15 and UBA7, which may provide a means of understanding the pathogenesis of rabies and improving therapeutic methods.
|
29056542 |
2017 |
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that shRNA knock-down of expression of ISG15 and UBA7 increased the titers of RABV in neuroblastoma cell line NA and microglial cell line BV-2 cells and shRNA knockdown of ISG15 conjugation alleviates the IFN-induced inhibition of RABV gene expression in vitro.
|
29056542 |
2017 |
Progression of prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, the ISGylation system controls AR mRNA and protein expressions, as overexpression of Ube1L as a limiting ISGylation factor in the AR(+) androgen-sensitive PCa cell line, LNCaP, results in significant AR upregulation, accompanied by an increased proliferation even under androgen deprivation.
|
19430494 |
2009 |
Sindbis virus infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The importance of UbE1L was confirmed by demonstrating that mice lacking this ISG15 E1 enzyme were highly susceptible to Sindbis virus infection.
|
19073728 |
2009 |
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that shRNA knock-down of expression of ISG15 and UBA7 increased the titers of RABV in neuroblastoma cell line NA and microglial cell line BV-2 cells and shRNA knockdown of ISG15 conjugation alleviates the IFN-induced inhibition of RABV gene expression in vitro.
|
29056542 |
2017 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |