|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
LHGDN |
Notably, retroviral expression of UBE1L rapidly induced apoptosis in NB4 APL cells, but not in cells lacking PML/RARalpha expression.
|
11891284 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
RA treatment of APL and other RA-responsive leukemic cells induced expression of UBE1L and ISG15 as well as intracellular ISG15 conjugates.
|
14976209 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
|
11891284 |
2002 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
|
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
|
Carcinoma of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
|
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-α through p38 MAPK and JNK signaling pathways in human lung carcinoma.
|
31428903 |
2019 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that shRNA knock-down of expression of ISG15 and UBA7 increased the titers of RABV in neuroblastoma cell line NA and microglial cell line BV-2 cells and shRNA knockdown of ISG15 conjugation alleviates the IFN-induced inhibition of RABV gene expression in vitro.
|
29056542 |
2017 |
|
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that shRNA knock-down of expression of ISG15 and UBA7 increased the titers of RABV in neuroblastoma cell line NA and microglial cell line BV-2 cells and shRNA knockdown of ISG15 conjugation alleviates the IFN-induced inhibition of RABV gene expression in vitro.
|
29056542 |
2017 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The effects of ISGylation on HCV were independent of upstream IFN signalling: IFN-alpha-induced ISG expression was not altered by Ube1L knockdown.
|
19846672 |
2010 |
|
Intellectual Disability
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The new ARID genes include nine with loss-of-function mutations (ABI2, MAPK8, MPDZ, PIDD1, SLAIN1, TBC1D23, TRAPPC6B, UBA7 and USP44), and missense mutations include the first reports of variants in BDNF or TET1 associated with ID.
|
28397838 |
2018 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
Biomarker
|
disease |
BEFREE |
In contrast, the proteasomal inhibitor, N-acetyl-leucinyl-leucinyl-norleucinal, inhibited both UBE1L- and RA-mediated PML/RARalpha degradation.
|
18413804 |
2008 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
Biomarker
|
disease |
BEFREE |
We previously identified the ubiquitin-activating enzyme-E1-like protein (UBE1L) as an RA-regulated target gene in APL that triggers PML/RARalpha degradation and apoptosis.
|
14976209 |
2004 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Notably, retroviral expression of UBE1L rapidly induced apoptosis in NB4 APL cells, but not in cells lacking PML/RARalpha expression.
|
11891284 |
2002 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
This difference in expression of the UBE1L protein between normal lung tissue and lung tumor-derived cell lines suggests a possible involvement of an E1-like protein in the origin and/or progression of lung tumors.
|
10709110 |
2000 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
These upregulated genes, including serine/arginine-rich splicing factors (SRSFs; such as <i>SRSF2</i>, <i>SRSF5</i>, <i>SRSF7</i>, and <i>SRSF8</i>) that are associated with messenger RNA splicing and export, and ubiquitin conjugating enzyme E2 (UBE2) members (such as <i>UBE2D2</i>, <i>UBE2G2</i>, <i>UBE2J1</i>, and <i>UBE2E1</i>) that are crucial for protein ubiquitination and protein processing in endoplasmic reticulum (ER), were identified as negative prognostic biomarkers of PCa, as the high expression of them correlated with poor overall survival of PCa patients.
|
31841638 |
2019 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Upregulated genes, including serine/arginine-rich splicing factors (SRSFs; such as SRSF2, SRSF5, SRSF7 and SRSF8), and ubiquitin conjugating enzyme E2 (UBE2) members (such as UBE2D2, UBE2G2, UBE2J1 and UBE2E1), were identified as negative prognostic biomarkers of PCa, as the high expression of them correlated with poor overall survival of PCa patients.
|
31563279 |
2019 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In contrast, UBE1L mRNA expression was markedly repressed in several cancer cell lines.
|
14976209 |
2004 |
|
Mood Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
These findings also provide a mechanistic basis for the tumor suppressive effects of UBE1L through cyclin D1 repression.
|
15520223 |
2004 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that shRNA knock-down of expression of ISG15 and UBA7 increased the titers of RABV in neuroblastoma cell line NA and microglial cell line BV-2 cells and shRNA knockdown of ISG15 conjugation alleviates the IFN-induced inhibition of RABV gene expression in vitro.
|
29056542 |
2017 |