|
Squamous cell carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Even though UBA1 or UBA7, the early enzymes involved in protein ubiquitination and ubiquitin-like regulation of target proteins, did not underlie the exposure-related deregulation of ubiquitination, a difference was detected in the UBA1 and UBA7 levels between squamous cell carcinomas and respective normal lung tissue (p = 0.02 and p = 0.01) without regard to exposure status.
|
19014429 |
2008 |
|
Mood Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-α through p38 MAPK and JNK signaling pathways in human lung carcinoma.
|
31428903 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
Biomarker
|
disease |
BEFREE |
In contrast, the proteasomal inhibitor, N-acetyl-leucinyl-leucinyl-norleucinal, inhibited both UBE1L- and RA-mediated PML/RARalpha degradation.
|
18413804 |
2008 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
Biomarker
|
disease |
BEFREE |
We previously identified the ubiquitin-activating enzyme-E1-like protein (UBE1L) as an RA-regulated target gene in APL that triggers PML/RARalpha degradation and apoptosis.
|
14976209 |
2004 |
|
Carcinoma of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Notably, retroviral expression of UBE1L rapidly induced apoptosis in NB4 APL cells, but not in cells lacking PML/RARalpha expression.
|
11891284 |
2002 |
|
Carcinoma of lung
|
0.030 |
Biomarker
|
disease |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
These upregulated genes, including serine/arginine-rich splicing factors (SRSFs; such as <i>SRSF2</i>, <i>SRSF5</i>, <i>SRSF7</i>, and <i>SRSF8</i>) that are associated with messenger RNA splicing and export, and ubiquitin conjugating enzyme E2 (UBE2) members (such as <i>UBE2D2</i>, <i>UBE2G2</i>, <i>UBE2J1</i>, and <i>UBE2E1</i>) that are crucial for protein ubiquitination and protein processing in endoplasmic reticulum (ER), were identified as negative prognostic biomarkers of PCa, as the high expression of them correlated with poor overall survival of PCa patients.
|
31841638 |
2019 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Upregulated genes, including serine/arginine-rich splicing factors (SRSFs; such as SRSF2, SRSF5, SRSF7 and SRSF8), and ubiquitin conjugating enzyme E2 (UBE2) members (such as UBE2D2, UBE2G2, UBE2J1 and UBE2E1), were identified as negative prognostic biomarkers of PCa, as the high expression of them correlated with poor overall survival of PCa patients.
|
31563279 |
2019 |
|
Virus Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The UBE1L level induced in human fibroblast cells by interferon beta treatment or virus infection was reduced by pUL50 expression.
|
29743376 |
2018 |
|
Virus Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We assessed the role of ISG15-UbE1L interactions in control of virus infection by constructing double subgenomic Sindbis viruses that expressed the mISG15 R151A mutant.
|
19073728 |
2009 |
|
Acute Promyelocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
RA treatment of APL and other RA-responsive leukemic cells induced expression of UBE1L and ISG15 as well as intracellular ISG15 conjugates.
|
14976209 |
2004 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
These findings also provide a mechanistic basis for the tumor suppressive effects of UBE1L through cyclin D1 repression.
|
15520223 |
2004 |
|
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
|
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
UBE1L mRNA was shown previously as repressed in certain lung cancer cell lines, directly implicating UBE1L in lung carcinogenesis.
|
15520223 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
LHGDN |
Notably, retroviral expression of UBE1L rapidly induced apoptosis in NB4 APL cells, but not in cells lacking PML/RARalpha expression.
|
11891284 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
|
11891284 |
2002 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
|
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Assessment of the level and distribution pattern of the UBE1L protein in normal and tumor tissue using the generated antibodies showed that the UBE1L protein was present in normal lung cells and non-lung cancer cell lines, but was undetectable in all 14 human lung cancer cell lines analyzed.
|
10709110 |
2000 |
|
Intellectual Disability
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The new ARID genes include nine with loss-of-function mutations (ABI2, MAPK8, MPDZ, PIDD1, SLAIN1, TBC1D23, TRAPPC6B, UBA7 and USP44), and missense mutations include the first reports of variants in BDNF or TET1 associated with ID.
|
28397838 |
2018 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that shRNA knock-down of expression of ISG15 and UBA7 increased the titers of RABV in neuroblastoma cell line NA and microglial cell line BV-2 cells and shRNA knockdown of ISG15 conjugation alleviates the IFN-induced inhibition of RABV gene expression in vitro.
|
29056542 |
2017 |
|
Rabies (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
To our knowledge, we for the first time documented the anti-RABV function of ISG15 and UBA7, which may provide a means of understanding the pathogenesis of rabies and improving therapeutic methods.
|
29056542 |
2017 |