|
Lupus Erythematosus, Systemic
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
UBE2L3 was up-regulated in SLE patients in several types of immune cells.Methylations (e.g. cg06850285) and mRNA expression of UBE2L3 were causally associated with SLE.
|
31670388 |
2020 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.
|
27193031 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
This is consistent with earlier reports on higher expression of UBE2L3 in patients with SLE.
|
25880549 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
The UBE2L3 risk allele correlated with increased circulating plasmablast and plasma cell numbers in SLE individuals, consistent with substantially elevated UBE2L3 protein levels in plasmablasts and plasma cells.
|
25640675 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.
|
24091983 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.490 |
SusceptibilityMutation
|
disease |
ORPHANET |
Variants in TNFSF4, TNFAIP3, TNIP1, BLK, SLC15A4 and UBE2L3 interact to confer risk of systemic lupus erythematosus in Chinese population.
|
24091983 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.490 |
Biomarker
|
disease |
BEFREE |
CFH (P=8.41 × 10(-6)), HLA-DRA (P=4.91 × 10(-6)), HLA-DRB1 (P=9.46 × 10(-9)), PXK (P=3.62 × 10(-4)), BLK (P=9.32 × 10(-3)), and UBE2L3 (P=4.07 × 10(-3)) were identified as shared genes between IgAN and SLE.
|
24458077 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.490 |
SusceptibilityMutation
|
disease |
ORPHANET |
Advances in lupus genetics.
|
23917156 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.490 |
SusceptibilityMutation
|
disease |
ORPHANET |
Genetics and epigenetics of systemic lupus erythematosus.
|
23943494 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.490 |
SusceptibilityMutation
|
disease |
ORPHANET |
The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression.
|
22476155 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression.
|
22476155 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.490 |
SusceptibilityMutation
|
disease |
ORPHANET |
We studied the UBE2L3 risk allele for association with SLE, interferon-α (IFN-α), and autoantibodies in a predominantly African American SLE cohort.
|
22045845 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
We studied the UBE2L3 risk allele for association with SLE, interferon-α (IFN-α), and autoantibodies in a predominantly African American SLE cohort.
|
22045845 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The findings confirm the association of the BLK and UBE2L3 loci with RA, thus adding to the list of loci showing overlap between RA and SLE.
|
21068098 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.490 |
Biomarker
|
disease |
BEFREE |
SNPs in the SLE susceptibility loci BANK1, KIAA1542, and UBE2L3 showed evidence of association with anti-dsDNA + SLE and were not associated with anti-dsDNA - SLE.
|
21408207 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.490 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
|
18204446 |
2008 |