|
Obesity
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
OBESITY, SEVERE, AND TYPE II DIABETES
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Decreased resting energy expenditure
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Increased waist to hip ratio
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
Spontaneously occurring microscopic lung and lymph node metastases (in athymic mice) of a low metastatic human lung carcinoma cell line, UCP3, and its high metastatic variant, MV522, were isolated.
|
2244163 |
1990 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude it is unlikely that variants in the coding region of the UCP3 gene contribute to the pathogenesis of juvenile-onset obesity among Danish Caucasians.
|
9498661 |
1998 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The UCP3 variant was not significantly associated with metabolic rate or obesity.
|
9700198 |
1998 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
Two recently described proteins in the mitochondrial uncoupling protein (UCP) family, UCP-2 and UCP-3, have been linked to phenotypes of obesity and NIDDM.
|
9726246 |
1998 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In contrast, mRNA levels of UCP-3 were significantly reduced in skeletal muscle of NIDDM patients compared with control subjects.
|
9726246 |
1998 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate whether obesity is accompanied by aberrations in UCP2 and UCP3 regulation.
|
9726596 |
1998 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
With the capacity to participate in thermogenesis and energy balance, UCP3 is an important obesity candidate gene.
|
9769326 |
1998 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
With the capacity to participate in thermogenesis and energy balance, UCP3 is an important obesity candidate gene.
|
9769326 |
1998 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.
|
9769326 |
1998 |
|
Obesity, Morbid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.
|
9769326 |
1998 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We conclude that 1) skeletal muscle mRNA levels encoding UCP2 and UCP3 are correlated among individuals and may be coordinately regulated; 2) UCP3 expression is not regulated by differential effects on UCP3L and UCP3S forms of the mRNA; and 3) UCP mRNA expression tends to increase in muscle as a function of obesity but not of resting metabolic rate or insulin resistance, and is increased in patients with type 2 diabetes.
|
9836527 |
1998 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We conclude that 1) skeletal muscle mRNA levels encoding UCP2 and UCP3 are correlated among individuals and may be coordinately regulated; 2) UCP3 expression is not regulated by differential effects on UCP3L and UCP3S forms of the mRNA; and 3) UCP mRNA expression tends to increase in muscle as a function of obesity but not of resting metabolic rate or insulin resistance, and is increased in patients with type 2 diabetes.
|
9836527 |
1998 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
From the three different human UCPs identified so far by gene cloning both UCP2 and UCP3 were mapped in close proximity (75-150 kb) to regions of human chromosome 11 (11q13) that have been linked to obesity and hyperinsulinaemia.
|
10027754 |
1999 |
|
Hyperinsulinism
|
0.020 |
Biomarker
|
disease |
BEFREE |
From the three different human UCPs identified so far by gene cloning both UCP2 and UCP3 were mapped in close proximity (75-150 kb) to regions of human chromosome 11 (11q13) that have been linked to obesity and hyperinsulinaemia.
|
10027754 |
1999 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The data suggest that it is not a reduction in UCP2 or UCP3 expression that causes obesity in the susceptible mice.
|
10066417 |
1999 |
|
Anorexia Nervosa
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In the current study we have used classical case-control association analysis to determine whether two highly polymorphic microsatellite markers, located within a 3-cM region of the UCP-2/UCP-3 locus, show involvement of this region of the human genome in the predisposition to AN.
|
10089012 |
1999 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In this paper, we investigated whether altered UCP2 and UCP3 mRNA levels are associated with obesity or weight reduction.
|
10102249 |
1999 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
UCP2 and UCP3 could therefore have an important role in body weight regulation and susceptibility to diabetes.
|
10382588 |
1999 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
UCP2 and UCP3 could therefore have an important role in body weight regulation and susceptibility to diabetes.
|
10382588 |
1999 |
|
Metabolic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Very recently, the cloning of UCP2 and UCP3, two homologues of UCP1, has renewed the field of research on the importance of respiration control in metabolic processes and metabolic diseases.
|
10395193 |
1999 |