|
Obesity
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
OBESITY, SEVERE, AND TYPE II DIABETES
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Decreased resting energy expenditure
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Increased waist to hip ratio
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
UCP3 -55C>T polymorphism carriers have apparently a lower risk of obesity when taking into consideration recreational energy expenditure.
|
16006788 |
2005 |
|
Impaired glucose tolerance
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
UCP3 protein content was significantly lower in prediabetic IGT subjects and in diabetic patients compared with healthy controls (39.0 +/- 28.5, 47.2 +/- 24.7, and 72.0 +/- 23.7 arbitrary units, respectively; P < 0.05), whereas the levels of the mitochondrial protein complex I-V were similar between groups.
|
16384852 |
2006 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
UCP3-55C/T and the RPTOR-26934C/T may only have subtle effects on the development of obesity-related traits in the present humans.
|
25533680 |
2014 |
|
Hypertensive disease
|
0.210 |
Biomarker
|
group |
BEFREE |
UCP3 protein was involved in the incidence of high-salt induced hypertension and the progression of cardiac dysfunction in the early stages of heart failure.
|
29694982 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Ala55Val and -55C/T polymorphisms at the UCP3-2 loci are associated with a significantly reduced risk of developing type 2 diabetes in Asian Indians.
|
21175267 |
2011 |
|
hearing impairment
|
0.200 |
Biomarker
|
phenotype |
RGD |
A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats.
|
22543089 |
2012 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A variant in the putative promoter region of UCP3 (-55 c-->t) has recently been identified, and an association with obesity reported in French subjects.
|
11151767 |
2000 |
|
Arthritis, Psoriatic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, 1,25(OH)2D significantly increased ATP levels and gene expression related to mitochondrial function such as carnitine palmitoyltransferase 1 (CPT1), peroxisome proliferator-activated receptor α (PPARα), very long-chain acyl-CoA dehydrogenase (VLCAD), long-chain acyl-CoA dehydrogenase (LCAD), medium-chain acyl-CoA dehydrogenase (MCAD), uncoupling protein 2 (UCP2), and UCP3 and the vitamin D pathway including 25-dihydroxyvitamin D3 24-hydroxylase (CYP24) and 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27) in PA-treated C2C12 myotubes.
|
31744213 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
After confirming that myocardial UCP3 levels were systematically decreased by 20-49% in animal models of insulin resistance and type 2 diabetes, we genetically engineered Sprague-Dawley rats with partial loss of UCP3 (ucp3<sup>+/-</sup>).
|
30374710 |
2018 |
|
Prediabetes syndrome
|
0.210 |
GeneticVariation
|
disease |
BEFREE |
After the adjustment for possible covariates, the A allele of rs1800849 in UCP3 was significantly associated with prediabetes (aOR<sub>AA vs GG</sub> = 1.68, 95% CI: 1.02-2.78), and the association was also significant under the recessive model (aOR <sub>AA vs GA + GG</sub> = 1.64, 95% CI: 1.02-2.66).
|
29529994 |
2018 |
|
Hyperthyroidism
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Although induction of the UCP3 gene and increased protein expression during hyperthyroidism has been shown, there are no convincing data that increased UCP3 levels account for the increase in thermogenesis in the hyperthyroid state in humans.
|
16175492 |
2005 |
|
Heart failure
|
0.220 |
Biomarker
|
disease |
BEFREE |
Although LVAD treatment improved clinical markers of heart failure (decrease of left ventricular diastolic dimension and normalization of serum sodium), only UCP3 expression reversed to non-failing transcript levels following mechanical unloading.
|
12145475 |
2002 |
|
Congestive heart failure
|
0.220 |
Biomarker
|
disease |
BEFREE |
Although LVAD treatment improved clinical markers of heart failure (decrease of left ventricular diastolic dimension and normalization of serum sodium), only UCP3 expression reversed to non-failing transcript levels following mechanical unloading.
|
12145475 |
2002 |
|
Anorexia Nervosa
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa.
|
11920154 |
2002 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents.
|
17870627 |
2007 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children.
|
24124336 |
2013 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of UCP-3 rs1626521 with obesity and stomach functions in humans.
|
25755013 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Beta2-adrenergic receptor and UCP3 variants modulate the relationship between age and type 2 diabetes mellitus.
|
17150099 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
RGD |
Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity.
|
15356383 |
2004 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
But neither the UCP2 Ala55Val nor the UCP3 -55C/T polymorphism showed any significant association with obesity risk in either subjects of Asian (REM OR = 0.84, 95% CI: 0.67-1.06 for Ala55Val; REM OR = 0.94, 95% CI: 0.55-1.28 for -55C/T) or of European descent (REM OR = 1.04, 95% CI: 0.80-1.36 for Ala55Val; FEM OR = 1.08, 95% CI: 0.97-1.20 for -55C/T).
|
23560041 |
2013 |