|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of lncRNA XIST can repress the myocardial cell apoptosis in AMI model rats by downregulating miR-449 level.
|
31646589 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
LncRNA XIST expression is upregulated in several cancers, however, its biologic role in the development of the chemotherapy of human lung adenocarcinoma (LAD) has not been elucidated.
|
28961027 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
To identify the most feasible candidates in a particular tissue (lung adenocarcinomas), we considered protein-coding genes that (1) were positively correlated with XIST expression within sexes, (2) were targeted by miRNAs shared with XIST, and (3) expressed in lung adenocarcinoma.
|
31419261 |
2019 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNAs (lncRNAs) XIST and HIF1A-AS1 have been shown to play important regulatory roles in cancer biology, and lncRNA-XIST and HIF1A-AS1 are upregulated in several cancers such as glioblastoma, breast cancer and thoracoabdominal aorta aneurysm, however, its value in the diagnosis of non-small cell lung cancer (NSCLC) is unclear.
|
26339353 |
2015 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In vivo results demonstrated lncRNA-XIST knockdown reduces the tumorigenicity of glioblastoma cells.
|
31680298 |
2020 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we elucidated the function and the possible molecular mechanisms of lncRNA XIST in human glioblastoma stem cells (GSCs).
|
25578780 |
2015 |
|
Adult Teratoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ring X chromosome mosaicism was present in the amniotic cell culture and in the teratoma and the ring X was inactive (X-inactive specific transcript (XIST) locus expressed).
|
11755101 |
2002 |
|
Alopecia universalis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Turner syndrome female with a small ring X chromosome lacking the XIST, an unexpectedly mild phenotype and an atypical association with alopecia universalis.
|
15337477 |
2004 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the current study was to investigate the effect and molecular mechanism of the lncRNA X-inactive specific transcript (XIST) in AD.
|
31743528 |
2020 |
|
Aortic Aneurysm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNAs (lncRNAs) XIST and HIF1A-AS1 have been shown to play important regulatory roles in cancer biology, and lncRNA-XIST and HIF1A-AS1 are upregulated in several cancers such as glioblastoma, breast cancer and thoracoabdominal aorta aneurysm, however, its value in the diagnosis of non-small cell lung cancer (NSCLC) is unclear.
|
26339353 |
2015 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Long noncoding RNA X-inactive specific transcript (XIST) has been reported to be implicated in atherosclerosis.
|
31539155 |
2019 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data provide insight into the role of the lncRNA XIST in ox-LDL mediated ECs injury, which can aid in developing new therapeutic strategies for the treatment of atherosclerosis.
|
29902461 |
2018 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data provide insight into the role of the lncRNA XIST in ox-LDL mediated ECs injury, which can aid in developing new therapeutic strategies for the treatment of atherosclerosis.
|
29902461 |
2018 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Long noncoding RNA X-inactive specific transcript (XIST) has been reported to be implicated in atherosclerosis.
|
31539155 |
2019 |
|
Bladder Neoplasm
|
0.050 |
Biomarker
|
disease |
BEFREE |
LncRNA XIST may act as an inhibitor of miR-200c to regulate the stemness properties and tumourigenicity of bladder cancer cells, and our findings might reveal a potential strategy of targeting XIST for bladder cancer therapy.
|
29559853 |
2018 |
|
Bladder Neoplasm
|
0.050 |
Biomarker
|
disease |
BEFREE |
The correlations of miR-124 with XIST and AR in bladder cancer samples were statistically analyzed.
|
28869948 |
2017 |
|
Bladder Neoplasm
|
0.050 |
Biomarker
|
disease |
BEFREE |
Mechanistically, we confirmed that lncRNA XIST participates in bladder cancer by downregulating p53 via binding to TET1.
|
30362292 |
2019 |
|
Bladder Neoplasm
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
High expression of XIST was significantly associated with tumour progression and poor prognosis of patients with bladder cancer.
|
31602223 |
2019 |
|
Bladder Neoplasm
|
0.050 |
Biomarker
|
disease |
BEFREE |
Taken together, our study suggested that lncRNA XIST may serve as a prognostic biomarker and a potential therapeutic target for bladder cancer.
|
29212249 |
2017 |
|
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results suggest that XIST is down-regulated in breast cancer and suppresses breast cancer cell growth, migration, and invasion via the miR-155/CDX1 axis.
|
29550489 |
2018 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
XIST and 53BP1 may be predictive biomarkers in BRCA1-like breast cancer.
|
26637364 |
2016 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
For functional illustrations and downstream signaling pathways analysis, XIST, H19 and MALAT1 mainly shared their regulatory functions in cell motility and interleukin signaling in breast cancer progression.
|
30092355 |
2018 |
|
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, decreased Xist expression in breast cancer samples was associated with reduced levels of Jpx RNA, an lncRNA that positively regulates Xist promoter activity.
|
27248326 |
2016 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Here, we profiled long noncoding RNAs in brain metastatic tumors from patients with breast cancer and found that the X-inactive-specific transcript (XIST) was significantly downregulated in these tissues.
|
30026327 |
2018 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We investigated this topic by assessing XIST behaviour in different groups of breast carcinomas and in a panel of breast cancer cell lines both BRCA1 mutant and wild type.
|
19440381 |
2009 |