XIST, X inactive specific transcript, 7503

N. diseases: 146; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1848138
Disease: X INACTIVATION, FAMILIAL SKEWED, 1 (disorder)
X INACTIVATION, FAMILIAL SKEWED, 1 (disorder) 		0.300 Biomarker disease CTD_human
CUI: C0000786
Disease: Spontaneous abortion
Spontaneous abortion 		0.100 Biomarker phenotype HPO
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.010 Biomarker disease BEFREE <b>Conclusion:</b> The <i>miR-15a-5p-XIST-CUL3</i> regulatory axis was related to the pathogenesis of sepsis-induced AKI. 31658856 2019
CUI: C0796004
Disease: Kabuki make-up syndrome
Kabuki make-up syndrome 		0.010 GeneticVariation disease BEFREE Kabuki syndrome-like features associated with a small ring chromosome X and XIST gene expression. 11484209 2001
CUI: C0041408
Disease: Turner Syndrome
Turner Syndrome 		0.040 GeneticVariation disease BEFREE Turner syndrome female with a small ring X chromosome lacking the XIST, an unexpectedly mild phenotype and an atypical association with alopecia universalis. 15337477 2004
CUI: C0014060
Disease: Encephalitis, St. Louis
Encephalitis, St. Louis 		0.010 AlteredExpression disease BEFREE SLE T cells also have altered expression of XIST RNA interactome genes, accounting for perturbations of Xi epigenetic features. 30944248 2019
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.010 AlteredExpression disease BEFREE SLE T cells also have altered expression of XIST RNA interactome genes, accounting for perturbations of Xi epigenetic features. 30944248 2019
CUI: C0033770
Disease: Prune Belly Syndrome
Prune Belly Syndrome 		0.010 Biomarker disease BEFREE Prune-belly syndrome and other anomalies in a stillborn fetus with a ring X chromosome lacking XIST. 9129738 1997
CUI: C0205851
Disease: Germ cell tumor
Germ cell tumor 		0.010 AlteredExpression disease BEFREE XIST expression was common in seminomatous testicular germ cell tumors (2 of 2 or 100% of seminoma derived cell lines and 10 of 12 or 83% of seminomatous testicular germ cell tumor tissues) but not in nonseminomatous testicular germ cell tumors (0 of 2 or 0% nonseminoma derived cell lines and 2 of 8 or 25% of nonseminomatous testicular germ cell tumor tissues). 12629412 2003
CUI: C0036631
Disease: Seminoma
Seminoma 		0.020 AlteredExpression disease BEFREE XIST expression was common in seminomatous testicular germ cell tumors (2 of 2 or 100% of seminoma derived cell lines and 10 of 12 or 83% of seminomatous testicular germ cell tumor tissues) but not in nonseminomatous testicular germ cell tumors (0 of 2 or 0% nonseminoma derived cell lines and 2 of 8 or 25% of nonseminomatous testicular germ cell tumor tissues). 12629412 2003
CUI: C1335059
Disease: testicular nonseminoma
testicular nonseminoma 		0.010 AlteredExpression disease BEFREE XIST expression was common in seminomatous testicular germ cell tumors (2 of 2 or 100% of seminoma derived cell lines and 10 of 12 or 83% of seminomatous testicular germ cell tumor tissues) but not in nonseminomatous testicular germ cell tumors (0 of 2 or 0% nonseminoma derived cell lines and 2 of 8 or 25% of nonseminomatous testicular germ cell tumor tissues). 12629412 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. 14723995 2004
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.020 Biomarker disease BEFREE XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. 14723995 2004
CUI: C0855197
Disease: Malignant Testicular Germ Cell Tumor
Malignant Testicular Germ Cell Tumor 		0.010 Biomarker disease BEFREE XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. 14723995 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.010 GeneticVariation group BEFREE X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors. 17545591 2007
CUI: C0432475
Disease: XX males
XX males 		0.010 PosttranslationalModification disease BEFREE XIST methylation was 18% in (SRY+) XX-males, and thus they were severely hypomethylated compared to (SRY-) XX-males (48%; P<0.01), Klinefelter men (44%; P<0.01) and female controls (47%; P<0.01). 19812237 2010
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.060 Biomarker disease BEFREE XIST and 53BP1 may be predictive biomarkers in BRCA1-like breast cancer. 26637364 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.060 Biomarker disease BEFREE XIST and 53BP1 may be predictive biomarkers in BRCA1-like breast cancer. 26637364 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.090 Biomarker disease BEFREE XIST promoted CRC cell proliferation by affecting the cell cycle. 28730777 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE XIST, one of the first found cancer-associated lncRNAs, has been frequently reported to play major role in several biological processes. 28771809 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE XIST, one of the first found cancer-associated lncRNAs, has been frequently reported to play major role in several biological processes. 28771809 2018
CUI: C0030193
Disease: Pain
Pain 		0.020 Biomarker phenotype BEFREE XIST silencing alleviated pain behaviors including both mechanical and thermal hyperalgesia in the CCI rats. 29115665 2018
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal 		0.030 Biomarker phenotype BEFREE XIST silencing alleviated pain behaviors including both mechanical and thermal hyperalgesia in the CCI rats. 29115665 2018
CUI: C0260037
Disease: Multiple tumors
Multiple tumors 		0.010 Biomarker phenotype BEFREE X-inactive specific transcript (XIST), an lncRNA, is known as an oncogene in multiple tumors. 29219216 2018
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.100 Biomarker disease BEFREE XIST was identified to function as a competitive endogenous RNA (ceRNA) for miR-137 to promote NSCLC cell viability and invasion. 29337100 2018