|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the current study was to investigate the effect and molecular mechanism of the lncRNA X-inactive specific transcript (XIST) in AD.
|
31743528 |
2020 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study exhibits the role of XIST as a miRNA sponge in RCC and supports the potential application of XIST in RCC therapy.
|
30717973 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulated expression of XIST led to an increase in miR-93-5p expression, thereby decreasing CDKN1A and suppressing renal interstitial fibrosis in DN.
|
31545928 |
2019 |
|
Encephalitis, St. Louis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SLE T cells also have altered expression of XIST RNA interactome genes, accounting for perturbations of Xi epigenetic features.
|
30944248 |
2019 |
|
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
LncRNA XIST was overespressed in esophageal cancer tissues and cells.
|
30551480 |
2019 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these in vivo and in vitro findings identify XIST as a necessary regulator of cardiac hypertrophy due to its regulation of the miR-101/TLR2 axis, suggesting that XIST might act as a therapeutic target for the treatment of cardiac hypertrophy and heart failure.
|
30605239 |
2019 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these in vivo and in vitro findings identify XIST as a necessary regulator of cardiac hypertrophy due to its regulation of the miR-101/TLR2 axis, suggesting that XIST might act as a therapeutic target for the treatment of cardiac hypertrophy and heart failure.
|
30605239 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> The <i>miR-15a-5p-XIST-CUL3</i> regulatory axis was related to the pathogenesis of sepsis-induced AKI.
|
31658856 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SLE T cells also have altered expression of XIST RNA interactome genes, accounting for perturbations of Xi epigenetic features.
|
30944248 |
2019 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In short, the current study showed that XIST was a crucial regulator in progression and oxaliplatin resistance of MM, providing a novel insight into the pathogenesis and underlying therapeutic target for MM.
|
30640294 |
2019 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA XIST regulates myocardial infarction by targeting miR-130a-3p.
|
29226319 |
2019 |
|
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
XIST was significantly upregulated in neuroblastoma tissues (<i>n</i> = 30) and cells lines, and it was statistically associated with the age and International Neuroblastoma Staging System (INSS) staging in neuroblastoma patients.
|
31208278 |
2019 |
|
Osteoporosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It was revealed that XIST was significantly upregulated in plasma and monocytes from patients with OP compared with the normal controls.
|
30651866 |
2019 |
|
Esophageal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA XIST was overespressed in esophageal cancer tissues and cells.
|
30551480 |
2019 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of lncRNA XIST can repress the myocardial cell apoptosis in AMI model rats by downregulating miR-449 level.
|
31646589 |
2019 |
|
Neuroendocrine Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
LncRNA XIST depletion prevents cancer progression in invasive pituitary neuroendocrine tumor by inhibiting bFGF via upregulation of microRNA-424-5p.
|
31564894 |
2019 |
|
Renal interstitial fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulated expression of XIST led to an increase in miR-93-5p expression, thereby decreasing CDKN1A and suppressing renal interstitial fibrosis in DN.
|
31545928 |
2019 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Lentiviruses targeting sh-XIST (LV-sh-XIST) were injected into ALF model mice via tail vein to elucidate the in vivo role of XIST in ALF injury.
|
31418997 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study exhibits the role of XIST as a miRNA sponge in RCC and supports the potential application of XIST in RCC therapy.
|
30717973 |
2019 |
|
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The objective of the study was to elucidate the roles and underlying mechanisms of XIST in laryngeal squamous cell carcinoma.
|
31071316 |
2019 |
|
Malignant neoplasm of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA XIST was overespressed in esophageal cancer tissues and cells.
|
30551480 |
2019 |
|
Malignant neoplasm of gastrointestinal tract
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, subgroup analysis based on cancer type revealed that lncRNA XIST expression correlated with distant metastasis in digestive cancer (OR = 2.90, 95% CI = 1.80-4.68; P < .001).
|
30653128 |
2019 |
|
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
XIST was significantly upregulated in neuroblastoma tissues (<i>n</i> = 30) and cells lines, and it was statistically associated with the age and International Neuroblastoma Staging System (INSS) staging in neuroblastoma patients.
|
31208278 |
2019 |
|
MOHR-TRANEBJAERG SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the role of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) and multidrug resistance-1 (MDR1) in tumor tissue samples and the chemoresistant human NSCLC cell lines, H460/DDP and A549/DDP, and in a murine A549/DDP tumor xenograft.
|
31659146 |
2019 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
Biomarker
|
disease |
BEFREE |
A functional lncRNA, X‑inactive specific transcript (XIST), was identified in the disease network and the main miRNAs (miR‑424‑5p and miR‑497‑5p) that are regulated by XIST were further screened to obtain the ceRNA regulatory network of DCM.
|
31173240 |
2019 |