|
Oral Cavity Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Distribution of altered XRCC1 gene haplotype was higher in OCC cases.
|
30954277 |
2020 |
|
Refractory Cytopenia of Childhood
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
From the prospective German clinical cohort study (RCC-Registry), 99 patients with papillary mRCC treated with systemic first-line therapy between December 2007 and May 2017 were included.
|
31498894 |
2020 |
|
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results provided compelling preclinical support that Cx-platin-Cl and Cx-DN604-Cl could reverse chemo-immune resistance via decaying JWA-XRCC1-mediated SSBR and immunosuppression, improving the development of emerging Pt(IV) candidate as a potential immunotherapeutic agent for cancer resistant prevention.
|
31703842 |
2020 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
They are structurally organized, containing canonical promyelocytic leukemia (PML) nuclear body protein SP100 concentrated in a peripheral layer, and XRCC1 in the center.
|
30260704 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results reveal that XRCC1-contaning foci constitute newly recognized PML-like nuclear bodies that accrete and locally deliver essential factors for repair of single-strand DNA breaks in replication regions.-Kordon, M. M., Szczurek, A., Berniak, K., Szelest, O., Solarczyk, K., Tworzydło, M., Wachsmann-Hogiu, S., Vaahtokari, A., Cremer, C., Pederson, T., Dobrucki, J. W. PML-like subnuclear bodies, containing XRCC1, juxtaposed to DNA replication-based single-strand breaks.
|
30260704 |
2019 |
|
Alveolar Soft Part Sarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Laboratory A results were as follows: archival cases (42 of 98, 43%), ASPS (16 of 19, 84%), and Xp11-RCC (7 of 8, 88%).
|
30851332 |
2019 |
|
Heredodegenerative Disorders, Nervous System
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Arguably the most exciting aspect of XRCC1 function that has emerged in the last few years is its intimate relationship with PARP1 activity and critical role in preventing hereditary neurodegenerative disease.
|
31324530 |
2019 |
|
Hereditary Leiomyomatosis and Renal Cell Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on these results, we analyzed the outcome of bevacizumab plus erlotinib in Korean patients with HLRCC-associated RCC.
|
30913859 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results showed that IPF fibroblasts residing in a collagen rich matrix are resistance to cisplatin-induced cell death due to the aberrantly high CK2/XRCC1-dependent DNA repair activity.
|
30850922 |
2019 |
|
Promyelocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
They are structurally organized, containing canonical promyelocytic leukemia (PML) nuclear body protein SP100 concentrated in a peripheral layer, and XRCC1 in the center.
|
30260704 |
2019 |
|
Non-obstructive azoospermia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated if substitutions in the ERCC1, ERCC2, and XRCC1 genes of the DNA repair pathway correlate with non-obstructive azoospermia and male infertility.
|
30390177 |
2019 |
|
Lung diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
MATERIAL AND METHODS The XRCC1 gene T-77C, Arg194Trp, Arg280His, Arg399Gln, COMT gene 186C>T, and Val158Met mutations were evaluated in peripheral blood collected from 261 non-smoking female patients diagnosed with primary lung cancer and 265 female patients with benign lung disease.
|
30109864 |
2018 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Molecular marker analysis suggested that Polb- and Xrcc1-deficient medulloblastomas belonged to the SHHα subtype, underscoring the important role of genomic stability in preventing this devastating pediatric cerebellar tumor.
|
30274781 |
2018 |
|
Osteitis Deformans
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that carrying the allele T of XRCC1 rs1799782 polymorphism and the allele G of APEX rs1130409 polymorphism increased the risk of developing PDB.
|
29630930 |
2018 |
|
Osteosarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these findings revealed that XRCC1 rs3213245 polymorphism was associated with increased risk of OS, which could affect XRCC1 expression in vitro and in vivo.
|
30464596 |
2018 |
|
Henoch-Schoenlein Purpura
|
0.010 |
Biomarker
|
disease |
BEFREE |
They include new HCAs genes such as GRM1 (SCA44), FAT2 (SCA45), PLD3 (SCA46), SCYL1 (SCAR21), UBA5 (SCAR24) and XRCC1 (SCAR26) as well as CAPN1 (SPG76) and CPT1C (SPG73) in HSPs.
|
29847346 |
2018 |
|
Hepatitis E
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recent GWAS-associated studies reported that single nucleotide polymorphisms (SNPs) in ABCB1, TGFβ1, XRCC1 genes were associated with hepatitis A virus (HAV) infection, and variants of APOA4 and APOE genes were associated with and hepatitis E virus (HEV) infection in US population.
|
29558945 |
2018 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, we report 2 cases of aggressive ESC-RCC course including widespread bone metastases in addition to 2 typical indolent tumors.
|
29885406 |
2018 |
|
Myelofibrosis due to another disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Progression to secondary myelofibrosis/leukemia is influenced by exposure to cytoreductive agents, and caspase and BER polymorphisms {globally, CASP8 3'untranslated region [odds ratio (OR)=0.24; 95% confidence interval (CI), 0.08‑0.69], XRCC1 Arg194Trp [OR=3.58; 95% CI, 0.98‑13.01]; for essential thrombocythemia patients CASP9 Arg173His [OR=11.27; 95% CI, 1.13‑112.28], APEX1 Asp148Glu [OR=0.28; 95% CI, 0.74‑1.03], and XRCC1 Arg194Trp [OR=6.60; 95% CI, 1.60‑27.06]}.
|
30320340 |
2018 |
|
Absence of sensation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, this study showed modulations of hOGG1 and XRCC1 expression especially 1 day after elective surgery in patients undergoing PROP and ISO anaesthesia.
|
29669111 |
2018 |
|
Osteosarcoma of bone
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these findings revealed that XRCC1 rs3213245 polymorphism was associated with increased risk of OS, which could affect XRCC1 expression in vitro and in vivo.
|
30464596 |
2018 |
|
Malignant Female Reproductive System Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Overall, no significant association between any of the studied XRCC1 polymorphisms and gynecologic cancer risk was observed.
|
28391259 |
2018 |
|
Atypical Lipoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RAP1 or XRCC1 downregulation cooperated with ATRX loss in driving the ALT phenotype.
|
29545335 |
2018 |
|
Childhood Cerebellar Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Molecular marker analysis suggested that Polb- and Xrcc1-deficient medulloblastomas belonged to the SHHα subtype, underscoring the important role of genomic stability in preventing this devastating pediatric cerebellar tumor.
|
30274781 |
2018 |
|
Childhood Osteosarcoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these findings revealed that XRCC1 rs3213245 polymorphism was associated with increased risk of OS, which could affect XRCC1 expression in vitro and in vivo.
|
30464596 |
2018 |