|
Epithelioid angiomyolipoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Herein, we describe a series of six primary and metastatic ESC-RCCs morphologically and immunophenotypically mimicking epithelioid angiomyolipoma (eAML).
|
29885406 |
2018 |
|
Acquired cystic disease associated renal cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
ACKD-RCC-like cysts should be recognized as a distinct entity from ACKD-RCC, defined by the lack of any solid nodular growth within the cyst.
|
30001236 |
2018 |
|
Autoimmune Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
However, there was no significant association between XRCC1 Arg194Trp polymorphism and autoimmune diseases in different genetic models.
|
27812739 |
2017 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the presence of SNP rs11615 from ERCC1, rs13181 from ERCC2, and rs25487 from XRCC1 and the relationship between risk factors such as smoking, alcohol intake, hypertension, and diabetes.
|
27668351 |
2017 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We analyzed the presence of SNP rs11615 from ERCC1, rs13181 from ERCC2, and rs25487 from XRCC1 and the relationship between risk factors such as smoking, alcohol intake, hypertension, and diabetes.
|
27668351 |
2017 |
|
Genital Neoplasms, Female
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer.
|
28415705 |
2017 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pressure overload-induced heart failure is more severe in the mice lacking XRCC1, an essential protein for SSB repair, which is rescued by blocking DDR activation through genetic deletion of ATM, suggesting the causative role of SSB accumulation and DDR activation in the pathogenesis of heart failure.
|
28436431 |
2017 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pressure overload-induced heart failure is more severe in the mice lacking XRCC1, an essential protein for SSB repair, which is rescued by blocking DDR activation through genetic deletion of ATM, suggesting the causative role of SSB accumulation and DDR activation in the pathogenesis of heart failure.
|
28436431 |
2017 |
|
Microcephaly
|
0.010 |
Biomarker
|
disease |
BEFREE |
One of the most important interactions of XRCC1 is that with polynucleotide kinase/phosphatase (PNKP), a dual-function DNA kinase/phosphatase that processes damaged DNA termini and that, if mutated, results in ataxia with oculomotor apraxia 4 (AOA4) and microcephaly with early-onset seizures and developmental delay (MCSZ).
|
28821613 |
2017 |
|
Myeloproliferative disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The role of base excision repair (BER) genes in Philadelphia-negative (PN)-myeloproliferative neoplasms (MPNs) susceptibility was evaluated by genotyping eight polymorphisms [apurinic/apyrimidinic endodeoxyribonuclease 1, mutY DNA glycosylase, earlier mutY homolog (<i>E. coli</i>) (MUTYH), 8-oxoguanine DNA glycosylase 1, poly (ADP-ribose) polymerase (PARP) 1, PARP4 and X-ray repair cross-complementing 1 (XRCC1)] in a case-control study involving 133 Caucasian Portuguese patients.
|
28599464 |
2017 |
|
Nasal Polyps
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, no interaction was found between XRCC1 (Arg399Gln) polymorphism genotypes and Cd in association with NP disease.
|
27838878 |
2017 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Investigation of Polymorphisms in DNA Repair Genes (XRCC1, APE1 and XPD) in Women with Polycystic Ovary Syndrome
|
28610405 |
2017 |
|
Urologic Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Although overall analyses suggested a null result for XRCC1-rs25487 polymorphism, in the stratified analysis by ethnicity, an increased risk of urological neoplasms for Asians in allelic and homozygote models was identified.
|
28330811 |
2017 |
|
Secondary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cabozantinib treatment caused striking tumor regression and inhibited lung metastasis in TSG-RCC-030.
|
27715452 |
2017 |
|
Early radiation dermatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
T stage and smoking status were significantly associated with acute radiation oral mucositis with Grade ≥2 (OR = 2.508, P = .001, 95% CI: 1.427-4.408, OR = 6.355, P < .001, 95% CI: 2.533-15.841).The XRCC1 codon 399 genotype in NPC could be an important predicting factor in the risk of acute radiation dermatitis during IMRT.
|
29095251 |
2017 |
|
Squamous cell carcinoma of tongue
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of APE-1 and XRCC-1 was evaluated by immunohistochemistry in 82 cases of oral tongue squamous cell carcinoma.
|
27925687 |
2017 |
|
Progressive cerebellar ataxia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we show that biallelic mutations in the human XRCC1 gene are associated with ocular motor apraxia, axonal neuropathy, and progressive cerebellar ataxia.
|
28002403 |
2017 |
|
hiv-infection/aids
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association Between XRCC1 and WRN as Genetic Markers of Stability and Susceptibility to Cancer in Patients with HIV/AIDS and Cancer: a Cross-Sectional Study
|
28440612 |
2017 |
|
Apraxia, oculomotor, Cogan type
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we show that biallelic mutations in the human XRCC1 gene are associated with ocular motor apraxia, axonal neuropathy, and progressive cerebellar ataxia.
|
28002403 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings indicated that decreased XRCC1 expression was associated with lymph node metastasis but was not an independent prognostic factor in ccRCC patients.
|
29312615 |
2017 |
|
Papillary Renal Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TSG-RCC-030 provides a realistic preclinical model to better understand the development and progression of pRCC with MET mutation and accelerate the development of new therapies for pRCC.
|
27715452 |
2017 |
|
SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
One of the most important interactions of XRCC1 is that with polynucleotide kinase/phosphatase (PNKP), a dual-function DNA kinase/phosphatase that processes damaged DNA termini and that, if mutated, results in ataxia with oculomotor apraxia 4 (AOA4) and microcephaly with early-onset seizures and developmental delay (MCSZ).
|
28821613 |
2017 |
|
Solid Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
KPT-9274 is being evaluated in a phase I human clinical trial in solid tumors and lymphomas, which will allow this data to be rapidly translated into the clinic for the treatment of RCC.
|
27390344 |
2016 |
|
Squamous cell carcinoma of oropharynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Carriers of combined genotypes of c.580C>T and TTGG haplotype of XRCC1 gene were under 3.35- and 3.22-fold increased risk of OPSCC than others.
|
27372710 |
2016 |
|
Superficial ulcer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the presence of the Gln/Gln, Arg/His, and His/His genotypes of XRCC1 was significantly more likely to have bone erosion and extra-articular features in RA patients.
|
26692147 |
2016 |