|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to examine the association of common genetic variation in the base-excision repair (BER) pathway with bladder cancer risk, we analyzed 43 single nucleotide polymorphisms (SNPs) in 12 BER genes (OGG1, MUTYH, APEX1, PARP1, PARP3, PARP4, XRCC1, POLB, POLD1, PCNA, LIG1, and LIG3).
|
17203305 |
2007 |
|
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphism of DNA repair genes OGG1, XRCC1, XPD and ERCC6 in bladder cancer in Belarus.
|
25089939 |
2014 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy.
|
23553206 |
2013 |
|
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, in the case of XRCC1, there was no significant difference in susceptibility to bladder cancer development between patients with the Arg399 and these with the Gln399 allele (OR.0.72 (95% CI, 0.41-1.26)).
|
17214369 |
2007 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study.
|
18365755 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between bladder cancer risk and the XRCC1 399 polymorphism. p53 mutations were found in 20.1% (35/174) patients.
|
20514470 |
2010 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The analysis suggests that the XRCC1 Arg399Gln polymorphism might be a moderate risk factor for bladder cancer, especially in non-Asian population.
|
24176953 |
2014 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no evidence of an association between any of the 14 XRCC1 polymorphisms and bladder cancer risk.
|
17425776 |
2007 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants in the XRCC1 gene might alter protein structure or function or create alternatively spliced proteins which may influence BER efficiency and hence affect individual susceptibility to bladder cancer.
|
24039945 |
2013 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the XRCC1 codon 399 polymorphism also had a protective effect on bladder cancer among heavy smokers.
|
14652287 |
2003 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype of XRCC1 also associated with significant risk for PCa and BC.
|
22019847 |
2012 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we recruited 251 bladder cancer cases and 251 healthy controls to evaluate the effect of hOGG1 codon 326 and XRCC1 codon 399 polymorphisms on bladder cancer.
|
18272472 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results of the present study suggest that XRCC1 Arg399Gln polymorphism might not modify the susceptibility to bladder cancer.
|
23479765 |
2013 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After adjustment for age and smoking, the PCNA-6084C variant was significantly associated with an increased risk of bladder cancer [CC + CG versus GG, odds ratio (OR), 1.61; 95% confidence interval (95% CI), 1.00-2.61], as well as the XRCC1-26651G variant (GG+AG versus AA: OR, 1.73; 95% CI, 1.17-2.56).
|
16284380 |
2005 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Further studies based on larger, stratified population were required to explore the role of XRCC1 polymorphisms in bladder cancer risk.
|
18765423 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DNA adducts were instead positively associated with occupational cumulative exposure to AAs (p = 0.028), whereas XRCC1 Arg 399 (p<0.006) was related with a decreased adduct levels, but with no impact on BC risk.
|
24722645 |
2014 |
|
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
XPD and XRCC1 appear to have no impact on the risk of bladder cancer.
|
11304692 |
2001 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that XRCC1 Arg194Trp and Arg280His polymorphisms were risk factors for increasing bladder cancer in Asian population.
|
24266849 |
2013 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified no association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk.
|
25501209 |
2014 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested whether polymorphisms in XRCC1 were associated with bladder cancer risk and whether this association was modified by cigarette smoking.
|
11219769 |
2001 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, in the subgroup analysis by cancer type, we found that XRCC1-rs25489 polymorphism was associated with an increased risk of bladder cancer (BC) in heterozygote model.
|
28330811 |
2017 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our data are consistent with a potential role of the XRCC1 Arg399Gln polymorphism in bladder cancer susceptibility and further suggest that there may be DNA lesions important in bladder carcinogenesis, repaired by the base excision repair mechanism, that are not directly associated with tobacco smoking.
|
15298955 |
2004 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls.
|
22927776 |
2012 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first meta-analysis conducted in Asian investigating the correlation between XRCC1 polymorphisms and susceptibility to bladder cancer.
|
23704969 |
2013 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility.
|
18336890 |
2008 |