|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested whether polymorphisms in XRCC1 were associated with bladder cancer risk and whether this association was modified by cigarette smoking.
|
11219769 |
2001 |
|
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
XPD and XRCC1 appear to have no impact on the risk of bladder cancer.
|
11304692 |
2001 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk.
|
12223443 |
2002 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the XRCC1 codon 399 polymorphism also had a protective effect on bladder cancer among heavy smokers.
|
14652287 |
2003 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Our data are consistent with a potential role of the XRCC1 Arg399Gln polymorphism in bladder cancer susceptibility and further suggest that there may be DNA lesions important in bladder carcinogenesis, repaired by the base excision repair mechanism, that are not directly associated with tobacco smoking.
|
15298955 |
2004 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data are consistent with a potential role of the XRCC1 Arg399Gln polymorphism in bladder cancer susceptibility and further suggest that there may be DNA lesions important in bladder carcinogenesis, repaired by the base excision repair mechanism, that are not directly associated with tobacco smoking.
|
15298955 |
2004 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After adjustment for age and smoking, the PCNA-6084C variant was significantly associated with an increased risk of bladder cancer [CC + CG versus GG, odds ratio (OR), 1.61; 95% confidence interval (95% CI), 1.00-2.61], as well as the XRCC1-26651G variant (GG+AG versus AA: OR, 1.73; 95% CI, 1.17-2.56).
|
16284380 |
2005 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, the XRCC1 194 variant allele was associated with a reduced bladder cancer risk among heavy smokers [adjusted OR 0.4, 95% CI 0.2-0.9)].
|
16311243 |
2006 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The methodology is illustrated through an example based on a study about the joint effects of XRCC1 polymorphisms and smoking on bladder cancer.
|
16463309 |
2006 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to examine the association of common genetic variation in the base-excision repair (BER) pathway with bladder cancer risk, we analyzed 43 single nucleotide polymorphisms (SNPs) in 12 BER genes (OGG1, MUTYH, APEX1, PARP1, PARP3, PARP4, XRCC1, POLB, POLD1, PCNA, LIG1, and LIG3).
|
17203305 |
2007 |
|
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, in the case of XRCC1, there was no significant difference in susceptibility to bladder cancer development between patients with the Arg399 and these with the Gln399 allele (OR.0.72 (95% CI, 0.41-1.26)).
|
17214369 |
2007 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no evidence of an association between any of the 14 XRCC1 polymorphisms and bladder cancer risk.
|
17425776 |
2007 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we recruited 251 bladder cancer cases and 251 healthy controls to evaluate the effect of hOGG1 codon 326 and XRCC1 codon 399 polymorphisms on bladder cancer.
|
18272472 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In this study, we recruited 251 bladder cancer cases and 251 healthy controls to evaluate the effect of hOGG1 codon 326 and XRCC1 codon 399 polymorphisms on bladder cancer.
|
18272472 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility.
|
18336890 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study.
|
18365755 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Further studies based on larger, stratified population were required to explore the role of XRCC1 polymorphisms in bladder cancer risk.
|
18765423 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further studies based on larger, stratified population were required to explore the role of XRCC1 polymorphisms in bladder cancer risk.
|
18765423 |
2008 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the XRCC1 and APE1 polymorphisms may contribute to susceptibility to bladder cancer.
|
20218899 |
2010 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between bladder cancer risk and the XRCC1 399 polymorphism. p53 mutations were found in 20.1% (35/174) patients.
|
20514470 |
2010 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype of XRCC1 also associated with significant risk for PCa and BC.
|
22019847 |
2012 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls.
|
22927776 |
2012 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results of the present study suggest that XRCC1 Arg399Gln polymorphism might not modify the susceptibility to bladder cancer.
|
23479765 |
2013 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Crude odds ratios with 95% confidence intervals were used to assess the associations between XRCC1 Arg194Trp and Arg399Gln polymorphisms and bladder cancer risk.
|
23496911 |
2013 |
|
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapy.
|
23553206 |
2013 |