|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
The XRCC1 399Gln allele was associated with a reduction of risk of high-risk adenomas (OR 0.62, 95% CI 0.41-0.96).
|
16542436 |
2006 |
|
Adenoma
|
0.030 |
GeneticVariation
|
group |
BEFREE |
We have previously reported an inverse association between the XRCC1 codon 399 SNP and adenoma risk among these subjects.
|
17164360 |
2006 |
|
Adenoma of large intestine
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Using a large sigmoidoscopy-based case-control study (753 cases and 799 controls) in Los Angeles County, we investigated possible associations between single-nucleotide polymorphisms in the XRCC1 (codons 194 Arg/Trp and codon 399 Arg/Gln) and XRCC3 (codon 241 Thr/Met) genes and colorectal adenoma risk and their possible role as modifiers of the effect of monounsaturated fatty acid, the ratio of omega-6/omega-3 polyunsaturated fatty acids, and antioxidant intake.
|
15767338 |
2005 |
|
Adenoma of large intestine
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that polymorphisms in APEX1, XRCC1, and PARP1 may be associated with advanced colorectal adenoma.
|
17283177 |
2007 |
|
Adenoma of large intestine
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study.
|
16542436 |
2006 |
|
Adenosquamous carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In stratification analysis, significant elevated risk of adenocarcinoma/adenosquamous carcinoma was associated with the XRCC1 399GlnGln genotype among nonsmokers (OR = 3.85, 95% CI = 1.28-11.59, P = 0.017), but not among smokers.
|
15990162 |
2005 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In addition, the XRCC1 Arg194Trp polymorphism was associated with decreased NHL risk (Arg/Trp vs. Arg/Arg, OR: 0.72; 95% CI: 0.49-1.07; Trp/Trp vs. Arg/Arg, OR: 0.45; 95% CI: 0.10-1.99; p trend: 0.059), mainly in diffuse large B-cell lymphoma.
|
17666372 |
2007 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
DNA repair gene XRCC1 polymorphisms and haplotypes in diffuse large B-cell lymphoma in a Korean population.
|
19963133 |
2010 |
|
Adult Glioblastoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The highest odds ratios (ORs) for the associations were observed between the homozygous variant genotype XRCC1 Gln399Gln and the risk of glioma (OR = 1.32; 95% confidence interval, CI, 0.97-1.81), glioblastoma (OR = 1.48; 95% CI, 0.98-2.24), and meningioma (OR = 1.34; 95% CI, 0.96-1.86).
|
18330515 |
2008 |
|
Adult Glioblastoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we evaluated the association between polymorphisms in DNA repair genes, namely: XRCC1 rs25487, XRCC3 rs861539 and RAD51 rs1801320, with the susceptibility to develop glioblastoma.
|
26511493 |
2016 |
|
Adult Hepatocellular Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests the participation of XRCC1 Arg399Gln is a genetic susceptibility for hepatocellular cancer in Asians and breast cancer in Indians.
|
24205095 |
2013 |
|
Adult Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We observed that, in combination, allelic variants in the XPC Ala499Val, NBN Glu185Gln, XRCC3 Thr241Me, XRCC1 Arg194Trp, and XRCC1 399Gln polymorphisms modify the risk for developing HL.
|
21374732 |
2011 |
|
Adult Liver Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Surprisingly, we found that low ALDH2 expression levels associated with high XRCC1 expression levels are indicative for a poor overall survival, particularly in lung and liver cancer patients.
|
30088263 |
2018 |
|
Adult Liver Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We aimed to establish whether XRCC1, XRCC3, and XPD are associated with liver cancer in Pakistan and to examine the interaction of hepatitis B virus (HBV) or hepatitis C virus (HCV) with repaired genes in the occurrence of liver cancer.
|
23044807 |
2013 |
|
Adult Liver Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Trial sequential analysis (TSA), false-positive report probabilities (FPRP), and combined genotype analysis revealed that XRCC1 Arg399Gln is mainly associated with susceptibility to liver cancer.
|
30408066 |
2018 |
|
Adult Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma.
|
22047709 |
2012 |
|
Adult Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In this work, we retrospectively evaluated the influence of an XRCC1 polymorphism (rs25487) on the treatment results in a series of 73 patients with lymphoma subjected to ASCT.
|
21463129 |
2011 |
|
Adult Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
DNA repair gene XRCC1 polymorphisms could lead to defective DNA repair and increased risk of lymphoma.
|
19963133 |
2010 |
|
Adult Meningioma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the genotype of CAPS8, XRCC1, and NF2 was associated with different subtype of meningioma risk.
|
29581016 |
2018 |
|
Adult Meningioma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
However, in pair-wise comparisons a few SNP combinations were associated with the risk of brain tumors: Among others, carriers of both homozygous variant genotypes, i.e., XRCC1 Gln399Gln and XRCC3 Met241Met, were associated with a three-fold increased risk of glioma (OR = 3.18; 95% CI, 1.26-8.04) and meningioma (OR = 2.99; 95% CI, 1.16-7.72).
|
18330515 |
2008 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome.
|
26482462 |
2016 |
|
Adult Non-Hodgkin Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
DNA repair gene XRCC1 polymorphisms and non-Hodgkin lymphoma risk in a Chinese population.
|
19446740 |
2009 |
|
Adult Non-Hodgkin Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms in the DNA repair gene, XRCC1 associate with non-Hodgkin lymphoma susceptibility: A systematic review and meta-analysis.
|
26723520 |
2016 |
|
Advanced lung cancer
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Predictive assessment in pharmacogenetics of XRCC1 gene on clinical outcomes of advanced lung cancer patients treated with platinum-based chemotherapy.
|
26585370 |
2015 |
|
Advanced lung cancer
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The predictability of DNA repair XRCC1 (X-ray repair cross-complementing group 1 protein) single nucleotide polymorphisms (SNPs) for cisplatin-based grades 3 and 4 chemotherapy-related toxicity in patients with newly diagnosed advanced lung cancer was evaluated.
|
18400332 |
2008 |