|
Malignant neoplasm of gastrointestinal tract
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that inheritance of variant alleles in XRCC1 Arg194Trp and Arg399Gln SNPs may act as biomarkers for the early detection of GIC, especially for gastric and colorectal cancers in the Sabah population.
|
27221877 |
2016 |
|
Childhood Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome.
|
26482462 |
2016 |
|
Skin Erosion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the presence of the Gln/Gln, Arg/His, and His/His genotypes of XRCC1 was significantly more likely to have bone erosion and extra-articular features in RA patients.
|
26692147 |
2016 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome.
|
26482462 |
2016 |
|
Patent ductus arteriosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Combining ß-lapachone with XRCC1 knockdown or methoxyamine (MeOX), an apyrimidinic/apurinic (AP)-modifying agent, led to NQO1-dependent synergistic killing in PDA, NSCLC, breast and head and neck cancers.
|
26602448 |
2015 |
|
Fuchs Endothelial Dystrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Haplotypes of both polymorphisms of the XRCC1 were associated with FECD occurrence.
|
26388025 |
2015 |
|
Hypertensive disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our findings provide evidence for a contributory role of XRCC1 gene rs25487 variant in the development of hypertension, and this variant possibly acted in a recessive pattern.
|
25529925 |
2015 |
|
Lymphopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
XRCC1 A1196G was associated with the incidence of lymphopenia (p = 0.024) and diarrhea (p = 0.020).
|
26033426 |
2015 |
|
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
XRCC1 Arg/Gln+Gln/Gln genotype increased the risk of MS.
|
26562193 |
2015 |
|
Ovarian Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the impact of 135G>C RAD51 and XRCC1 Arg399Gln polymorphisms on ovarian carcinoma risk in Serbian women.
|
26406958 |
2015 |
|
Xeroderma pigmentosum, group B
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Nine single nucleotide polymorphisms (SNPs) of XRCC1 (X-ray repair cross-complementing 1), CD3EAP (CD3e molecule, epsilon associated protein), PPP1R13L (protein phosphatase 1, regulatory subunit 13 like), XPB (Xeroderma pigmentosum group B), XPC (Xeroderma pigmentosum group C) and XPF (Xeroderma pigmentosum group F) were genotyped by the Snapshot and TaqMan-MGB® probe techniques, in a study involving 102 CBP patients and 204 controls.
|
26681190 |
2015 |
|
Xeroderma pigmentosum, group F
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Nine single nucleotide polymorphisms (SNPs) of XRCC1 (X-ray repair cross-complementing 1), CD3EAP (CD3e molecule, epsilon associated protein), PPP1R13L (protein phosphatase 1, regulatory subunit 13 like), XPB (Xeroderma pigmentosum group B), XPC (Xeroderma pigmentosum group C) and XPF (Xeroderma pigmentosum group F) were genotyped by the Snapshot and TaqMan-MGB® probe techniques, in a study involving 102 CBP patients and 204 controls.
|
26681190 |
2015 |
|
Pseudoaphakia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Various combinations of the keywords and MeSH terms were used to screen for potentially relevant studies, specifically "genetic polymorphisms" or "SNPs" or "variation" or "single nucleotide polymorphism" or "polymorphism" or "mutation" or "variant"; "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "XPD" or "Xeroderma Pigmentosum Complementation Group D Protein" or "ERCC2" or "XRCC1" or "XRCC1 DNA repair protein"; and "Cataract" or " Membranous Cataract" or " Pseudoaphakia."
|
25873778 |
2015 |
|
Oropharyngeal disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
For polymorphism XRCC1 Arg399Gln, multivariate analysis showed that the 399Gln allele increased the risk of local disease relapse for irradiated oral and oropharyngeal patients (OR = 3.35; CI = 1.10-10.13) by over 3-fold.
|
26505394 |
2015 |
|
Malignant neoplasm of kidney
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Renal cell carcinoma with rhabdoid differentiation (RCC-R) in adult patients is an aggressive variant of renal cancer with no known specific genetic alterations.
|
25439741 |
2015 |
|
Renal carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Renal cell carcinoma with rhabdoid differentiation (RCC-R) in adult patients is an aggressive variant of renal cancer with no known specific genetic alterations.
|
25439741 |
2015 |
|
PATENT DUCTUS ARTERIOSUS 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Combining ß-lapachone with XRCC1 knockdown or methoxyamine (MeOX), an apyrimidinic/apurinic (AP)-modifying agent, led to NQO1-dependent synergistic killing in PDA, NSCLC, breast and head and neck cancers.
|
26602448 |
2015 |
|
Diabetic Nephropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No significant difference was observed in the genotype and allele distribution of eNOS -786T > C, intron 4a4b, p22phox 242C > T and XRCC1 Arg399Gln polymorphisms between T2DM groups with and without DN.
|
25041504 |
2014 |
|
Gonorrhea
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis findings revealed that GC patients with the GA+AA (A carrier) genotypes of XRCC1 Arg399Gln showed a lower effective clinical response (CR+PR) than those with the GG (A non-carrier) genotype (OR=0.41, 95 % CI 0.20∼0.82, P=0.012).
|
24590266 |
2014 |
|
Keratoconus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The A/G genotype and the A allele of the c.1196A>G polymorphism of the X-ray repair cross-complementing group 1 (XRCC1) were associated with increased, and the G/G genotype and the G allele, with decreased KC occurrence.
|
25356504 |
2014 |
|
Systemic Scleroderma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results corroborate the presence of genomic instability in SSc peripheral blood cells, as evaluated by increased DNA damage, and show that polymorphic sites of the XRCC1 and XRCC4 DNA repair genes may differentially influence DNA damage and the development of autoantibodies.
|
24488411 |
2014 |
|
Migraine Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In contrast, no statistically significant differences were found in genotype distributions of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) and XPG between migraine cases and controls (p>0.05).
|
24892639 |
2014 |
|
Malignant neoplasm of nasopharynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study provides an estimate of allele and genotype frequencies of XRCC1Arg280His, XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms in the Malaysian population and showed no association with nasopharyngeal cancer.
|
24761895 |
2014 |
|
Congenital contractural arachnodactyly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that, in the Thai population, polymorphisms in XRCC1 and OGG1 genes, particularly in combination, are associated with increased susceptibility to CCA, and that their role as modifiers of the effect of smoking and alcohol consumption influences the risk of CCA.
|
25335960 |
2014 |
|
Cancer of Nasopharynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study provides an estimate of allele and genotype frequencies of XRCC1Arg280His, XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms in the Malaysian population and showed no association with nasopharyngeal cancer.
|
24761895 |
2014 |