|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CAIX is overexpressed in a variety of tumor types and associated with increased metastasis and poor prognosis.
|
15342400 |
2004 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A tumor targeted gene vector modified with G250 monoclonal antibody for gene therapy.
|
18316136 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.
|
18482982 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, the attributes of PDHK1 and CAIX predict them to be promising targets for the design of new, specific inhibitors that could negatively influence tumor cell proliferation and survival, or increase efficacy of standard treatment regimens, and at the same time avoid normal tissue toxicity.
|
30509100 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with CA IX-positive tumors had a significantly lower disease-specific and overall survival than patients with CA IX-negative tumors (P = 0.033 and P = 0.044, respectively).
|
15240538 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibition of CA IX enzymatic activity with selective inhibitors, antibodies or labeled probes has been shown to reverse the acidic environment of solid tumors and reduce the tumor growth establishing the significant role of CA IX in tumorigenesis.
|
29181278 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Due to the proposed function of CAND1 in stabilizing CA IX, these molecules could represent an efficient tool to lower the amount of CA IX in hypoxic cancer cells, thus limiting its action in survival and the metastatic spread of tumors.
|
28388044 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Poly(ethylene glycol)-grafted polyethylenimine modified with G250 monoclonal antibody for tumor gene therapy.
|
19788387 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The objective of this study was to examine the prognostic significance of carbonic anhydrase IX (CAIX), an endogenous marker for tumor hypoxia; the cellular tumor antigen p53; and the apoptosis regulator Bcl-2, in triple-negative breast cancer (TNBC) patients.
|
28777433 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Direct measurements of tumour oxygenation, and surrogate markers of the hypoxic response in tumours (for instance, hypoxia inducible factor-1alpha, carbonic anhydrase 9 and glucose transporter-1) are well-established prognostic markers in solid cancers.
|
19840191 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CA IX is a tumour-associated carbonic anhydrase with proposed roles in pH modulation and intercellular communication.
|
12115877 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.
|
15556624 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis.
|
16428489 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CAIX functions to help produce and maintain an intracellular pH (pHi) favorable for tumor cell growth and survival, while at the same time participating in the generation of an increasingly acidic extracellular space, facilitating tumor cell invasiveness.
|
22289741 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The CA IX directed nanoplatform in combination with Sor has shown multiple benefits in overcoming drug resistance through (i) inhibition of p-AKT, (ii) upregulation of tumoricidal M1 macrophages resulting in induction of caspase 3/7 mediated apoptosis of Evr-res A498 cells in macrophage-RCC co-culturing condition, (iii) significant in vitro and in vivo Evr-res A498 tumor growth inhibition as compared to individual therapy, and (iv) untraceable liver and kidney toxicity in mice.
|
30179778 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PDAC cells with knockdown of CA9 formed smaller xenograft tumors in mice, and injection of gemcitabine inhibited tumor growth and significantly increased survival times of mice.
|
31078621 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several oxygen-dependent factors, e.g., CAIX (carbonic anhydrase IX) or phosphoglycerate kinase 1 (PGK1) interacting with the CXCR4/SDF1 axis (chemokine receptor 4/stromal cell derived factor 1) have been shown to be involved in processes of tumour pathology including tumourigenicity, tumour cell dissemination and poor survival in several solid tumour entities.
|
26510737 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor tissues were associated with a borderline increase of CA IX staining signal and slight but significant decrease of CA XII immunoreactivity, whereas no association was found for pVHL.
|
15849821 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
From the surgical specimens, a tissue microarray was constructed using triplicate tissue cores from the primary tumor and used for immunohistochemical staining for the following markers: carbonic anhydrase IX, dihydrofolate reductase, p16(INK4A) , and PARP1/2.
|
20665497 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of this work is to characterize the expression of the metabolism-related proteins MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX in a series of pediatric adrenocortical tumors.
|
28969033 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The current study explored the combined effect of CA9 gene polymorphisms and exposure to environmental carcinogens on the susceptibility of developing oral squamous cell carcinoma (OSCC) and the clinicopathological characteristics of the tumors.
|
23226559 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical staining of tumor tissue sections confirmed the increased expression of CAIX, HK2 and LDHA in ccRCC, validating the microarray data and supporting their potential as the energetic metabolism-related biomarkers of the ccRCC.
|
25998032 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We correlated array mRNA fold changes with carbonic anhydrase 9 (CA IX) staining of tumours as a surrogate marker of hypoxia.
|
16052224 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, MCT4 was associated with parametrial invasion and HPV18 infection, CD147 and GLUT1 with distant metastasis, CAIX with tumor size and HPV18 infection, and VEGFR-1 with local and lymphnode metastasis.
|
26525902 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma.
|
30349321 |
2018 |