|
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Moreover, recurrence after resection was common in cases that displayed zyxin overexpressions in the initial resected tumor (P = 0.05).
|
16680155 |
2006 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
LIM domains containing 1 (LIMD1) is a member of the Zyxin family proteins and functions as a tumor suppressor in lung cancer.
|
30600590 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Depletion of Zyxin resulted in significantly impaired colon cancer cell proliferation, migration, anchorage-independent growth, and tumor formation in xenograft animal models.
|
29967145 |
2018 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The Zyxin family comprises seven homologous proteins involved in migration and proliferation of many cell types of which Zyxin has been described as a tumour suppressor in ES.
|
24033704 |
2013 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Functional examination of zyxin by small interfering RNA-mediated knockdown in Hep3B cell line indicated a significant inhibition on cell migration through porous membrane (P = 0.002) and invasion through matrigel-coated membrane (P = 0.005).
|
16680155 |
2006 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Altogether, our results suggest that ZYX defective binding to ACTN4, which occupies focal adhesions instead of ACTN1, induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion.
|
25860875 |
2015 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Zyxin as a potential cancer prognostic marker promotes the proliferation and metastasis of colorectal cancer cells.
|
30697742 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
By regulating cell-cell junctions, integrin α5β1 expression, and cell-extracellular matrix adhesion, zyxin may regulate cancer cell motility and EMT during lung cancer development and progression.
|
22778267 |
2012 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Here, we highlight the interesting member of the Zyxin family TRIP6 [thyroid receptor interactor protein 6; also designated ZRP-1 (zyxin-related protein 1)] and review current literature to define its role in cell physiology and cancer.
|
22054418 |
2011 |
|
Malignant tumor of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results suggested that zyxin and nesprin-1 are not only promising therapeutic targets but also potential diagnostic biomarkers for colon cancer.
|
31501460 |
2019 |
|
Malignant tumor of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
In two of these data sets, one or two genes had relatively high frequencies not noticeable with rules involving 20 or 50 genes: desmin for classifying colon cancer versus normal tissue; and zyxin and secretory granule proteoglycan genes for classifying two types of leukemia.
|
16959042 |
2006 |
|
Colon Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results suggested that zyxin and nesprin-1 are not only promising therapeutic targets but also potential diagnostic biomarkers for colon cancer.
|
31501460 |
2019 |
|
Colon Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In two of these data sets, one or two genes had relatively high frequencies not noticeable with rules involving 20 or 50 genes: desmin for classifying colon cancer versus normal tissue; and zyxin and secretory granule proteoglycan genes for classifying two types of leukemia.
|
16959042 |
2006 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
By regulating cell-cell junctions, integrin α5β1 expression, and cell-extracellular matrix adhesion, zyxin may regulate cancer cell motility and EMT during lung cancer development and progression.
|
22778267 |
2012 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Zyxin as a potential cancer prognostic marker promotes the proliferation and metastasis of colorectal cancer cells.
|
30697742 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Here, we highlight the interesting member of the Zyxin family TRIP6 [thyroid receptor interactor protein 6; also designated ZRP-1 (zyxin-related protein 1)] and review current literature to define its role in cell physiology and cancer.
|
22054418 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells.
|
21920000 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Misregulation of nuclear functions of zyxin appears to be associated with pathogenic effects and diseases, such as prostate cancer and non-small-cell lung cancer.
|
30657586 |
2019 |
|
Tuberculosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
AMPLICOR MTB polymerase chain reaction test for identification of Mycobacterium tuberculosis in positive Difco ESP II broth cultures.
|
9127101 |
1997 |
|
Tuberculosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The reliability of the Gen-Probe enhanced Mycobacterium Tuberculosis Direct Test (E-MTD) for identification of M. tuberculosis complex (MTBC) in ESP II broth cultures of nonrespiratory specimens was evaluated by testing aliquots from 262 signal-positive bottles.
|
10626137 |
1999 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
LIM domains containing 1 (LIMD1) is a member of the Zyxin family proteins and functions as a tumor suppressor in lung cancer.
|
30600590 |
2019 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
By regulating cell-cell junctions, integrin α5β1 expression, and cell-extracellular matrix adhesion, zyxin may regulate cancer cell motility and EMT during lung cancer development and progression.
|
22778267 |
2012 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Misregulation of nuclear functions of zyxin appears to be associated with pathogenic effects and diseases, such as prostate cancer and non-small-cell lung cancer.
|
30657586 |
2019 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin.
|
16885336 |
2006 |