|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, when we examined tissue samples from humans who died as the result of an asthma attack, we found increased accumulation of zyxin compared with non-asthmatics and asthmatics who died of other causes.
|
28278518 |
2017 |
|
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Zyxin is upregulated in human breast cancer and positively correlates with histological stages and metastasis.
|
27030211 |
2016 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Together, these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation.
|
29967145 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Supporting the involvement of the microfilament network in tumor cell behavior, several actin-binding proteins, including zyxin, a potential regulator of actin polymerization, may play a role in oncogenesis.
|
15748890 |
2005 |
|
Carcinoma of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
The study of miR-16 and its target zyxin will shed light on diagnosis and therapy of laryngeal cancer.
|
21360639 |
2011 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
LIM domains containing 1 (LIMD1) is a member of the Zyxin family proteins and functions as a tumor suppressor in lung cancer.
|
30600590 |
2019 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
By regulating cell-cell junctions, integrin α5β1 expression, and cell-extracellular matrix adhesion, zyxin may regulate cancer cell motility and EMT during lung cancer development and progression.
|
22778267 |
2012 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using immunoprobing, we verified that collagen IV (α<sub>2</sub> and α<sub>6</sub> isoforms), zyxin, and myomesin protein levels were reduced in the DCM-failing hearts.
|
27837684 |
2017 |
|
Childhood Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In two of these data sets, one or two genes had relatively high frequencies not noticeable with rules involving 20 or 50 genes: desmin for classifying colon cancer versus normal tissue; and zyxin and secretory granule proteoglycan genes for classifying two types of leukemia.
|
16959042 |
2006 |
|
Colon Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results suggested that zyxin and nesprin-1 are not only promising therapeutic targets but also potential diagnostic biomarkers for colon cancer.
|
31501460 |
2019 |
|
Colon Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In two of these data sets, one or two genes had relatively high frequencies not noticeable with rules involving 20 or 50 genes: desmin for classifying colon cancer versus normal tissue; and zyxin and secretory granule proteoglycan genes for classifying two types of leukemia.
|
16959042 |
2006 |
|
Colon Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Zyxin regulates YAP activity through the colon cancer oncogene CDK8.
|
29967145 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings provide the first evidence that decreased expression level of ZYX impairs CRC cell proliferation and metastasis probably via the FA pathway.
|
30697742 |
2019 |
|
Endothelial dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Stretch appears to be an important factor in the development of endothelial dysfunction with zyxin as a potential therapeutic target to interfere with these early changes in endothelial cell phenotype.
|
20705921 |
2010 |
|
Enteritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Rho/HSP27 (HSPB1)/zyxin pathway, involved in tissue contraction and myofibroblast transdifferentiation, was also altered in radiation enteritis, suggesting that this pathway could be related to the fibrogenic process.
|
14982484 |
2004 |
|
Ewings sarcoma
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
We observe similar phenotypic changes after zyxin gene transfer in SK-N-MC cells, suggesting that zyxin has tumor suppressor activity in Ewing tumor cells.
|
15748890 |
2005 |
|
Ewings sarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In this work, we investigate the status of zyxin in Ewing tumors, a family of pediatric malignancies of bone and soft tissues, which are mainly associated with a t(11;22) chromosomal translocation encoding the EWS-FLI1 oncoprotein.
|
15748890 |
2005 |
|
Ewings sarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The Zyxin family comprises seven homologous proteins involved in migration and proliferation of many cell types of which Zyxin has been described as a tumour suppressor in ES.
|
24033704 |
2013 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We noted that statins reduced TGF-β activity, cell viability and invasiveness, Rho/ROCK activity, phosphorylation and activity of the TGF-β mediator Smad3, and expression of TGF-β targets ZYX and SERPINE1 in GBM and GBM-initiating cell (GIC) lines.
|
30899443 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We noted that statins reduced TGF-β activity, cell viability and invasiveness, Rho/ROCK activity, phosphorylation and activity of the TGF-β mediator Smad3, and expression of TGF-β targets ZYX and SERPINE1 in GBM and GBM-initiating cell (GIC) lines.
|
30899443 |
2019 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, we demonstrated that miR-16-1 expression was markedly decreased in human glioma cell lines, and for the first time, described the roles of miR-16-1 in cellular proliferation, migration, and invasion abilities of high-invasive glioma cells, and suggested that Zyxin may be one of putative target genes of miR-16-1.
|
23175429 |
2013 |
|
Influenza A
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, ZYX knockdown reduced the expression of type I IFN and an interferon-inducible gene after stimulation with polyI:C or influenza A virus RNA.
|
28928438 |
2017 |
|
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In two of these data sets, one or two genes had relatively high frequencies not noticeable with rules involving 20 or 50 genes: desmin for classifying colon cancer versus normal tissue; and zyxin and secretory granule proteoglycan genes for classifying two types of leukemia.
|
16959042 |
2006 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although there was no correlation between zyxin expression and tumor stagings, there was a significant increase in messenger RNA levels in hepatocellular carcinoma cases that presented with multifocal disease (211.5 +/- 936.9-fold) compared to those with solitary lesions (3.5 +/- 6.3-fold).
|
16680155 |
2006 |