|
Schizophrenia
|
0.430 |
AlteredExpression
|
disease |
BEFREE |
The discoidin domain receptor (DDR1) is highly expressed in oligodendrocytes during the neurodevelopmental myelination process and is genetically associated to schizophrenia.
|
18836851 |
2009 |
|
Schizophrenia
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
We replicated the association between DDR1 and SZ (rs1264323, adjusted P = 0.015).
|
30597424 |
2019 |
|
Schizophrenia
|
0.430 |
Biomarker
|
disease |
BEFREE |
In conclusion, we propose the DDR1 as a new susceptibility gene for schizophrenia.
|
17440435 |
2007 |
|
Malignant neoplasm of lung
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
To test whether the genetic variants of CAK genes modify the risk of lung cancer, we compared the manifestation of 25 single nucleotide polymorphisms (SNPs) and the haplotypes of Cdk7, MAT1 and cyclin H between 500 patients with lung cancer and 517 healthy controls.
|
17707548 |
2007 |
|
Malignant neoplasm of lung
|
0.350 |
Biomarker
|
disease |
BEFREE |
In contrast, cell lines of colon and lung cancer did not reveal any sex-dependent difference in the correlation between DDR1 and ZEB1.
|
31807189 |
2019 |
|
Malignant neoplasm of lung
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
DDR1 was expressed in a panel of human lung cancer cell lines, and high DDR1 levels in human lung tumors were associated with poor survival.
|
22223527 |
2012 |
|
Malignant neoplasm of lung
|
0.350 |
Biomarker
|
disease |
BEFREE |
Thus, minor Col IV α5(IV) chain supports lung cancer progression via DDR1-mediated cancer cell autonomous and non-autonomous mechanisms.
|
25992553 |
2015 |
|
Malignant neoplasm of lung
|
0.350 |
Biomarker
|
disease |
BEFREE |
Here, we provide novel evidence regarding the molecular mechanisms through which IGF-I/IGF-IR signaling triggers a functional cross-talk with GPER and DDR1 in both mesothelioma and lung cancer cells.
|
27384677 |
2016 |
|
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
Western blot experiments were performed using whole cell extracts to proof the presence of NEP protein in LNCaP and hPCPs.
|
14968440 |
2004 |
|
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
DDR-Defective Metastatic Prostate Cancers Are Susceptible to Olaparib.
|
31836603 |
2020 |
|
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
The results suggest that the analyzed structural motifs determine the subcellular distribution of NEP in epithelial LNCaP PC cells and stromal prostatic cells and therefore could be responsible for the altered cellular localization of NEP observed in PC.
|
14550292 |
2003 |
|
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
These experiments demonstrate that lentiviral NEP gene transfer is a novel targeted strategy for the treatment of NEP-deficient PC.
|
17415380 |
2007 |
|
Malignant neoplasm of prostate
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression of PCA-1 and DDR-1 was associated with a hormone-independent state of prostate cancer.
|
17970783 |
2008 |
|
Lung Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
DDR1 was expressed in a panel of human lung cancer cell lines, and high DDR1 levels in human lung tumors were associated with poor survival.
|
22223527 |
2012 |
|
Lung Neoplasms
|
0.320 |
Biomarker
|
group |
BEFREE |
Overall, our data suggest that IGF-I/IGF-IR system triggers stimulatory actions through both GPER and DDR1 in aggressive tumors as mesothelioma and lung tumors.
|
27384677 |
2016 |
|
Adenocarcinoma
|
0.310 |
AlteredExpression
|
group |
BEFREE |
DDR1 up-regulation tend to be more frequently observed in invasive adenocarcinoma (64%) compared to DDR1 expression in BAC (38%) (p=0.056).
|
20596615 |
2010 |
|
Heart failure
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Methods and Results- NEP mRNA was quantitated by real-time polymerase chain reaction (PCR) in left ventricular biopsies from patients with aortic valve stenosis (AS, n=19) and heart failure due to dilated cardiomyopathy (DCM, n=14), and control subjects with normal systolic function (CON, n=14).
|
11804980 |
2002 |
|
Congestive heart failure
|
0.210 |
AlteredExpression
|
disease |
BEFREE |
Methods and Results- NEP mRNA was quantitated by real-time polymerase chain reaction (PCR) in left ventricular biopsies from patients with aortic valve stenosis (AS, n=19) and heart failure due to dilated cardiomyopathy (DCM, n=14), and control subjects with normal systolic function (CON, n=14).
|
11804980 |
2002 |
|
Carcinoma of lung
|
0.150 |
Biomarker
|
disease |
BEFREE |
Here, we provide novel evidence regarding the molecular mechanisms through which IGF-I/IGF-IR signaling triggers a functional cross-talk with GPER and DDR1 in both mesothelioma and lung cancer cells.
|
27384677 |
2016 |
|
Carcinoma of lung
|
0.150 |
Biomarker
|
disease |
BEFREE |
In contrast, cell lines of colon and lung cancer did not reveal any sex-dependent difference in the correlation between DDR1 and ZEB1.
|
31807189 |
2019 |
|
Carcinoma of lung
|
0.150 |
Biomarker
|
disease |
BEFREE |
Thus, minor Col IV α5(IV) chain supports lung cancer progression via DDR1-mediated cancer cell autonomous and non-autonomous mechanisms.
|
25992553 |
2015 |
|
Carcinoma of lung
|
0.150 |
GeneticVariation
|
disease |
BEFREE |
To test whether the genetic variants of CAK genes modify the risk of lung cancer, we compared the manifestation of 25 single nucleotide polymorphisms (SNPs) and the haplotypes of Cdk7, MAT1 and cyclin H between 500 patients with lung cancer and 517 healthy controls.
|
17707548 |
2007 |
|
Carcinoma of lung
|
0.150 |
AlteredExpression
|
disease |
BEFREE |
DDR1 was expressed in a panel of human lung cancer cell lines, and high DDR1 levels in human lung tumors were associated with poor survival.
|
22223527 |
2012 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A negative correlation between DDR1 index (defined by the logarithmic value of DDR1 divided by ZEB1, based on the mRNA data from the RT-PCR analysis) and an invasive phenotype was observed in cancer cell lines in a sex-specific manner.
|
31807189 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, minor Col IV α5(IV) chain supports lung cancer progression via DDR1-mediated cancer cell autonomous and non-autonomous mechanisms.
|
25992553 |
2015 |