Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020476
Disease: Hyperlipoproteinemias
Hyperlipoproteinemias 		0.010 Biomarker disease BEFREE We describe a gel isoelectric focusing procedure for resolving into at least five bands the arginine-rich protein of very-low-density lipoproteins, and use the method in diagnosis of hyperlipoproteinemia type 3. 215348 1979
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.020 GeneticVariation disease BEFREE A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. 8649854 1996
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.020 GeneticVariation disease BEFREE We amplified and sequenced the multiple arginine coding area of the ARP gene in primary head and neck, non-small cell lung, and renal cell cancers. 9230196 1997
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 GeneticVariation group BEFREE We have reported the presence of a specific mutation (ATG50-->AGG) or deletion of codon 50 of the ARP gene in different tumor types (Shridhar et al., 1996, 1996a). 9174057 1997
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.020 GeneticVariation disease BEFREE Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers. 9174057 1997
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.020 GeneticVariation disease BEFREE Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers. 9174057 1997
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.010 GeneticVariation group BEFREE To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues. 10767373 2000
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.010 GeneticVariation disease BEFREE To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues. 10767373 2000
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.010 GeneticVariation disease BEFREE However, they were also found in its corresponding normal tissues, suggesting that variation of the ARP gene found in ESC is polymorphic. 10767373 2000
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.010 GeneticVariation disease BEFREE To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues. 10767373 2000
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 Biomarker disease BEFREE The selective, neuroprotective effect of MANF for dopaminergic neurons suggests that it may be indicated for the treatment of Parkinson's disease. 12794311 2003
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.020 GeneticVariation disease BEFREE To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC). 17072959 2006
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.020 GeneticVariation disease BEFREE To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC). 17072959 2006
CUI: C0039128
Disease: Syphilis
Syphilis 		0.020 Biomarker disease BEFREE The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis. 18554302 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 Biomarker disease BEFREE The rescue experiments confirm DmMANF as a functional ortholog of the human MANF gene thus opening the window for comparative studies of this protein family with potential for the treatment of Parkinson's disease. 19164766 2009
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker disease RGD Induction profile of MANF/ARMET by cerebral ischemia and its implication for neuron protection. 19773801 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.040 Biomarker group BEFREE In this study, we examined the protective effect of adeno-associated virus serotype 7 encoding MANF in a rodent model of stroke. 20685313 2010
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.100 Biomarker disease BEFREE Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson disease-like symptoms in a rat 6-hydroxydopamine model. 21047780 2011
CUI: C0018801
Disease: Heart failure
Heart failure 		0.010 Biomarker disease BEFREE Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure. 20970425 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 Biomarker disease BEFREE Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure. 20970425 2011
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.010 Biomarker disease BEFREE Accordingly, in light of its function as a potentially secreted cardiomyokine, MANF has translational potential as a novel therapy for ischemic heart disease. 20970425 2011
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 Biomarker disease BEFREE We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons. 23255601 2013
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 Biomarker disease BEFREE We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons. 23255601 2013
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 Biomarker disease BEFREE We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons. 23255601 2013
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.030 Biomarker disease BEFREE The more interesting results in this study were that MANF repressed the cleavage of caspase-3 triggered by focal cerebral ischemia. 25001514 2014