|
Lupus Erythematosus, Systemic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the patients with SLE disease activity index (SLEDAI) <12, PERK and MANF expressions were significantly decreased, compared with the patients with severe SLE (SLEDAI ≥ 12).
|
25226532 |
2014 |
|
Syphilis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
From September 2009 to August 2013, we collected 658 clinical specimens from 375 patients who presented with syphilis for genotyping to examine the number of 60-bp repeats in the acidic repeat protein (arp) gene, T. pallidum repeat (tpr) polymorphism, and tp0548 gene, and to detect A2058G and A2059G point mutations by restriction fragment length polymorphism.
|
24438059 |
2014 |
|
Middle Cerebral Artery Occlusion
|
0.020 |
Biomarker
|
disease |
BEFREE |
The recombinant human MANF was therapeutically administrated to the ipsilateral ventricle at 2 h after MCAO.
|
25001514 |
2014 |
|
Parkinson Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease.
|
25369767 |
2015 |
|
Autoimmune Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models.
|
25640174 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of glucocorticoid receptor isoforms and associations with serine/arginine-rich protein 30c and 40 in patients with systemic lupus erythematosus.
|
25665148 |
2015 |
|
Inflammatory disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models.
|
25640174 |
2015 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In particular, studies employing glial cell line-derived neurotrophic factor (GDNF) and its family member neurturin (NRTN), as well as the recently described cerebral dopamine neurotrophic factor (CDNF) and the mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown positive results in protecting and repairing dopaminergic neurons in various models of PD.
|
26616211 |
2016 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which degenerate in Parkinson's disease (PD).
|
27425895 |
2017 |
|
Parkinson Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Intrastriatal injection of mesencephalic astrocyte-derived neurotrophic factor (MANF) protein has been shown to provide neuroprotective and neurorestorative effects in a 6-hydroxydopamine (6-OHDA) - lesioned rat model of Parkinson's disease.
|
28131727 |
2017 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recent studies in rodent models have demonstrated that MANF mitigates diabetes, exerts neurotrophic function in neurodegenerative disease, protects cardiomyocytes and neurons in myocardial infarction and cerebral ischemia, respectively, and promotes immune cell phenotype switch from proinflammatory macrophages to prorepair anti-inflammatory macrophages.
|
28719799 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Recent studies in rodent models have demonstrated that MANF mitigates diabetes, exerts neurotrophic function in neurodegenerative disease, protects cardiomyocytes and neurons in myocardial infarction and cerebral ischemia, respectively, and promotes immune cell phenotype switch from proinflammatory macrophages to prorepair anti-inflammatory macrophages.
|
28719799 |
2017 |
|
Neurodegenerative Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Of them 12 are associated with other autoimmune diseases than SLE, whereas three genes (ZNF804A, CDK1, and MANF) have not previously been associated with autoimmunity.
|
28740209 |
2017 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In addition, for the first time, we have discovered that MANF can potentially serve as a urinary ER stress biomarker in ER stress-mediated kidney disease.
|
28719799 |
2017 |
|
nervous system disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
This review focuses on MANF, summarizing its unique structure, potential signaling pathway, and role in neurological disease.
|
28685189 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Total IgG levels to 11 different proteins known or predicted to be involved in reticulocyte binding or invasion (ARP, GAMA, P41, P12, PVX_081550, and five members of the PvRBP family), as well as the leading pre-erythrocytic vaccine candidate (CSP) were measured using a multiplexed bead-based assay.
|
28454546 |
2017 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis.
|
28440306 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls.
|
28216543 |
2017 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis.
|
28440306 |
2017 |
|
Retinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Vitreous MANF may be a promising protein biomarker for the indirect assessment of retinal disorders, which could provide indirect evidence of retinal pathology.
|
28367115 |
2017 |
|
Idiopathic chronic pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pathogenic genetic variants were identified in 58, 63, and 27% of patients with ARIP, an unexplained first episode of AP <35 years of age, and ICP without ARP, respectively.
|
28440306 |
2017 |
|
Prediabetes syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls.
|
28216543 |
2017 |