|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
The serum MANF in patients with AF was markedly lower than that in patients with SR, which was inversely correlated with atrial apoptosis in patients with AF.
|
31789884 |
2020 |
|
Chronic atrial fibrillation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that MANF down-regulation may lead to more atrial apoptosis in human chronic AF, indicating MANF as a potential therapeutic agent in AF treatment.
|
31789884 |
2020 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings provide insight into the mechanisms of MANF in promoting functional recovery from ischemic stroke.
|
31785307 |
2020 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, whether MANF exerts its protective effect against Aβ neurotoxicity in AD remains unknown.
|
30760285 |
2019 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, MANF may be a cancer suppressor and a potential therapeutic target for HCC.
|
31469428 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Circulating MANF concentrations were significantly higher in PD patients compared to controls (<i>P</i> < 0.001) and were positively correlated with Beck Depression Inventory (BDI) depression rating.
|
31555085 |
2019 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Circulating MANF concentrations were significantly higher in PD patients compared to controls (<i>P</i> < 0.001) and were positively correlated with Beck Depression Inventory (BDI) depression rating.
|
31555085 |
2019 |
|
Focal glomerulosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
K201 and MANF could be promising therapies for the treatment of podocyte ER stress-induced NS/FSGS.
|
31235574 |
2019 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MANF levels were also associated with the status of liver cirrhosis, advanced Tumor-Node-Metastasis (TNM) stage and tumor size.
|
31469428 |
2019 |
|
Multiple Epiphyseal Dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Treatment of MED chondrocytes with exogenous MANF led to a decrease in the cellular levels of BiP (GRP78), confirming MANF's potential to modulate ER stress responses.
|
30543055 |
2019 |
|
Nephrotic Syndrome
|
0.010 |
Biomarker
|
group |
BEFREE |
K201 and MANF could be promising therapies for the treatment of podocyte ER stress-induced NS/FSGS.
|
31235574 |
2019 |
|
Subarachnoid Hemorrhage
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MANF was mainly expressed in rat neurons, and its expression increased significantly at 3 h after SAH induction and peaked at 24 h. Stereotactic injection of rh-MANF into the cerebroventricle significantly increased the level of MANF, p-Akt, p-mouse double minute 2 homolog (p-MDM2), and B-cell lymphoma 2 (Bcl-2) in brain tissue, whereas it down-regulated the expression of P53, Bcl-2-associated X protein (Bax), and cleaved caspase-3, which indicated that neuronal apoptosis was remarkably suppressed.
|
30211660 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
MANF was mainly expressed in rat neurons, and its expression increased significantly at 3 h after SAH induction and peaked at 24 h. Stereotactic injection of rh-MANF into the cerebroventricle significantly increased the level of MANF, p-Akt, p-mouse double minute 2 homolog (p-MDM2), and B-cell lymphoma 2 (Bcl-2) in brain tissue, whereas it down-regulated the expression of P53, Bcl-2-associated X protein (Bax), and cleaved caspase-3, which indicated that neuronal apoptosis was remarkably suppressed.
|
30211660 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition.
|
31469428 |
2019 |
|
Metaphyseal chondrodysplasia Schmid type
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MANF plays a cytoprotective role in several soft tissues and is upregulated in conditions resulting from intracellular retention of mutant protein, including two skeletal diseases, metaphyseal chondrodysplasia, Schmid type (MCDS) and multiple epiphyseal dysplasia (MED).
|
30543055 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition.
|
31469428 |
2019 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Circulating MANF concentrations were significantly higher in PD patients compared to controls (<i>P</i> < 0.001) and were positively correlated with Beck Depression Inventory (BDI) depression rating.
|
31555085 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition.
|
31469428 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, MANF may be a cancer suppressor and a potential therapeutic target for HCC.
|
31469428 |
2019 |
|
Insulin-Like Growth Factor I Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results show that the mere IGF-1 deficiency seems to be responsible for an altered expression of genes coding for neurotrophic factors (particularly ciliary neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor), their receptors and signaling pathways (specially RET).
|
30708048 |
2019 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that MANF mRNA and protein levels were lower in HCC tissues versus adjacent non-cancer tissues.
|
31469428 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As an endoplasmic reticulum (ER) stress-related protein, mesencephalic astrocyte-derived neurotrophic factor (MANF) is involved in inflammatory diseases, such as rheumatoid arthritis.
|
29649564 |
2018 |
|
Retinal damage
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
It was recently shown that mesencephalic astrocyte-derived neurotrophic factor (MANF) induces alternative or M2 activation of immune cells after retinal damage in both fruit fly and mouse and mediates retinal repair.
|
29806020 |
2018 |
|
SPINOCEREBELLAR ATAXIA 17
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a recently identified neurotrophic factor, and increasing MANF expression ameliorated SCA17 neuropathology in TBP-105Q knock-in (KI) mouse model, indicating that MANF could be a therapeutic target for treating SCA17.
|
29378605 |
2018 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis.
|
28440306 |
2017 |