Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 AlteredExpression disease BEFREE We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls. 28216543 2017
CUI: C0030305
Disease: Pancreatitis
Pancreatitis 		0.010 Biomarker disease BEFREE Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis. 28440306 2017
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.010 Biomarker group BEFREE Vitreous MANF may be a promising protein biomarker for the indirect assessment of retinal disorders, which could provide indirect evidence of retinal pathology. 28367115 2017
CUI: C0341471
Disease: Idiopathic chronic pancreatitis
Idiopathic chronic pancreatitis 		0.010 Biomarker disease BEFREE Pathogenic genetic variants were identified in 58, 63, and 27% of patients with ARIP, an unexplained first episode of AP <35 years of age, and ICP without ARP, respectively. 28440306 2017
CUI: C0362046
Disease: Prediabetes syndrome
Prediabetes syndrome 		0.010 AlteredExpression disease BEFREE We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls. 28216543 2017
CUI: C1290884
Disease: Inflammatory disorder
Inflammatory disorder 		0.010 AlteredExpression group BEFREE Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models. 25640174 2015
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 Biomarker disease BEFREE We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons. 23255601 2013
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 Biomarker disease BEFREE We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons. 23255601 2013
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 Biomarker disease BEFREE We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons. 23255601 2013
CUI: C0018801
Disease: Heart failure
Heart failure 		0.010 Biomarker disease BEFREE Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure. 20970425 2011
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 Biomarker disease BEFREE Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure. 20970425 2011
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.010 Biomarker disease BEFREE Accordingly, in light of its function as a potentially secreted cardiomyokine, MANF has translational potential as a novel therapy for ischemic heart disease. 20970425 2011
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.010 GeneticVariation group BEFREE To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues. 10767373 2000
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.010 GeneticVariation disease BEFREE To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues. 10767373 2000
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.010 GeneticVariation disease BEFREE However, they were also found in its corresponding normal tissues, suggesting that variation of the ARP gene found in ESC is polymorphic. 10767373 2000
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.010 GeneticVariation disease BEFREE To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues. 10767373 2000
CUI: C0020476
Disease: Hyperlipoproteinemias
Hyperlipoproteinemias 		0.010 Biomarker disease BEFREE We describe a gel isoelectric focusing procedure for resolving into at least five bands the arginine-rich protein of very-low-density lipoproteins, and use the method in diagnosis of hyperlipoproteinemia type 3. 215348 1979
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion 		0.020 Biomarker disease BEFREE Here, we examined the effects of MANF on cerebral angiogenesis in a permanent middle cerebral artery occlusion model in rats. 31785307 2020
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.020 Biomarker group BEFREE In conclusion, MANF plays an important role in linking ER stress and liver inflammation by inhibiting the NF-κB/Snail signal pathway in EMT and HCC progression. 31469428 2019
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.020 Biomarker group BEFREE Recently, we have identified mesencephalic astrocyte-derived neurotrophic factor (MANF) and cysteine-rich with EGF-like domains 2 (CRELD2) as urinary ER stress biomarkers in ER stress-mediated kidney diseases. 30099615 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 AlteredExpression group BEFREE MANF levels were also associated with the status of liver cirrhosis, advanced Tumor-Node-Metastasis (TNM) stage and tumor size. 31469428 2019
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.020 Biomarker group BEFREE Many groups, including ours, have proved that MANF rescues neuronal loss in several neurological disorders, such as Parkinson's disease and cerebral ischemia. 30760285 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE In vitro experiments revealed that MANF suppressed the migration and invasion of hepatoma cells. 31469428 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.020 AlteredExpression group BEFREE These results suggested that the AP‑1 complex may be a novel regulator of MANF transcription, which may be involved in liver inflammation and fibrosis. 30365109 2018
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.020 AlteredExpression disease BEFREE Furthermore, MANF was strongly expressed in the liver tissues of patients with hepatitis B virus (HBV) infection, compared with in normal liver tissues from patients with hepatic hemangioma. 30365109 2018