|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recent studies in rodent models have demonstrated that MANF mitigates diabetes, exerts neurotrophic function in neurodegenerative disease, protects cardiomyocytes and neurons in myocardial infarction and cerebral ischemia, respectively, and promotes immune cell phenotype switch from proinflammatory macrophages to prorepair anti-inflammatory macrophages.
|
28719799 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Diabetes Mellitus
|
0.030 |
Biomarker
|
group |
BEFREE |
Recent studies in rodent models have demonstrated that MANF mitigates diabetes, exerts neurotrophic function in neurodegenerative disease, protects cardiomyocytes and neurons in myocardial infarction and cerebral ischemia, respectively, and promotes immune cell phenotype switch from proinflammatory macrophages to prorepair anti-inflammatory macrophages.
|
28719799 |
2017 |
|
Neurodegenerative Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Here we will discuss the structural motifs and physiological functions of CDNF and MANF as well as their therapeutic potential for the treatment of neurodegenerative diseases and diabetes.
|
27425895 |
2017 |
|
Cerebral Infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
The more interesting results in this study were that MANF repressed the cleavage of caspase-3 triggered by focal cerebral ischemia.
|
25001514 |
2014 |
|
Middle Cerebral Artery Occlusion
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we examined the effects of MANF on cerebral angiogenesis in a permanent middle cerebral artery occlusion model in rats.
|
31785307 |
2020 |
|
Hepatitis
|
0.020 |
Biomarker
|
group |
BEFREE |
In conclusion, MANF plays an important role in linking ER stress and liver inflammation by inhibiting the NF-κB/Snail signal pathway in EMT and HCC progression.
|
31469428 |
2019 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Recently, we have identified mesencephalic astrocyte-derived neurotrophic factor (MANF) and cysteine-rich with EGF-like domains 2 (CRELD2) as urinary ER stress biomarkers in ER stress-mediated kidney diseases.
|
30099615 |
2019 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
MANF levels were also associated with the status of liver cirrhosis, advanced Tumor-Node-Metastasis (TNM) stage and tumor size.
|
31469428 |
2019 |
|
nervous system disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
Many groups, including ours, have proved that MANF rescues neuronal loss in several neurological disorders, such as Parkinson's disease and cerebral ischemia.
|
30760285 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In vitro experiments revealed that MANF suppressed the migration and invasion of hepatoma cells.
|
31469428 |
2019 |
|
Hepatitis
|
0.020 |
AlteredExpression
|
group |
BEFREE |
These results suggested that the AP‑1 complex may be a novel regulator of MANF transcription, which may be involved in liver inflammation and fibrosis.
|
30365109 |
2018 |
|
Hepatitis B
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, MANF was strongly expressed in the liver tissues of patients with hepatitis B virus (HBV) infection, compared with in normal liver tissues from patients with hepatic hemangioma.
|
30365109 |
2018 |
|
Hepatitis B
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B.
|
29649564 |
2018 |
|
Autoimmune Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Of them 12 are associated with other autoimmune diseases than SLE, whereas three genes (ZNF804A, CDK1, and MANF) have not previously been associated with autoimmunity.
|
28740209 |
2017 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In addition, for the first time, we have discovered that MANF can potentially serve as a urinary ER stress biomarker in ER stress-mediated kidney disease.
|
28719799 |
2017 |
|
nervous system disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
This review focuses on MANF, summarizing its unique structure, potential signaling pathway, and role in neurological disease.
|
28685189 |
2017 |
|
Tumor Cell Invasion
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Total IgG levels to 11 different proteins known or predicted to be involved in reticulocyte binding or invasion (ARP, GAMA, P41, P12, PVX_081550, and five members of the PvRBP family), as well as the leading pre-erythrocytic vaccine candidate (CSP) were measured using a multiplexed bead-based assay.
|
28454546 |
2017 |
|
Autoimmune Diseases
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models.
|
25640174 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of glucocorticoid receptor isoforms and associations with serine/arginine-rich protein 30c and 40 in patients with systemic lupus erythematosus.
|
25665148 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the patients with SLE disease activity index (SLEDAI) <12, PERK and MANF expressions were significantly decreased, compared with the patients with severe SLE (SLEDAI ≥ 12).
|
25226532 |
2014 |
|
Syphilis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
From September 2009 to August 2013, we collected 658 clinical specimens from 375 patients who presented with syphilis for genotyping to examine the number of 60-bp repeats in the acidic repeat protein (arp) gene, T. pallidum repeat (tpr) polymorphism, and tp0548 gene, and to detect A2058G and A2059G point mutations by restriction fragment length polymorphism.
|
24438059 |
2014 |
|
Middle Cerebral Artery Occlusion
|
0.020 |
Biomarker
|
disease |
BEFREE |
The recombinant human MANF was therapeutically administrated to the ipsilateral ventricle at 2 h after MCAO.
|
25001514 |
2014 |
|
Syphilis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis.
|
18554302 |
2008 |