|
Lupus Erythematosus, Systemic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of glucocorticoid receptor isoforms and associations with serine/arginine-rich protein 30c and 40 in patients with systemic lupus erythematosus.
|
25665148 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the patients with SLE disease activity index (SLEDAI) <12, PERK and MANF expressions were significantly decreased, compared with the patients with severe SLE (SLEDAI ≥ 12).
|
25226532 |
2014 |
|
Syphilis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The sequence of the acidic repeat protein (arp) gene differentiates venereal from nonvenereal Treponema pallidum subspecies, and the gene has evolved under strong positive selection in the subspecies that causes syphilis.
|
18554302 |
2008 |
|
Syphilis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
From September 2009 to August 2013, we collected 658 clinical specimens from 375 patients who presented with syphilis for genotyping to examine the number of 60-bp repeats in the acidic repeat protein (arp) gene, T. pallidum repeat (tpr) polymorphism, and tp0548 gene, and to detect A2058G and A2059G point mutations by restriction fragment length polymorphism.
|
24438059 |
2014 |
|
Pancreatic carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers.
|
9174057 |
1997 |
|
Pancreatic carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC).
|
17072959 |
2006 |
|
Malignant neoplasm of pancreas
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC).
|
17072959 |
2006 |
|
Malignant neoplasm of pancreas
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers.
|
9174057 |
1997 |
|
Middle Cerebral Artery Occlusion
|
0.020 |
Biomarker
|
disease |
BEFREE |
The recombinant human MANF was therapeutically administrated to the ipsilateral ventricle at 2 h after MCAO.
|
25001514 |
2014 |
|
Middle Cerebral Artery Occlusion
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we examined the effects of MANF on cerebral angiogenesis in a permanent middle cerebral artery occlusion model in rats.
|
31785307 |
2020 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis.
|
28440306 |
2017 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, whether MANF exerts its protective effect against Aβ neurotoxicity in AD remains unknown.
|
30760285 |
2019 |
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As an endoplasmic reticulum (ER) stress-related protein, mesencephalic astrocyte-derived neurotrophic factor (MANF) is involved in inflammatory diseases, such as rheumatoid arthritis.
|
29649564 |
2018 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
The serum MANF in patients with AF was markedly lower than that in patients with SR, which was inversely correlated with atrial apoptosis in patients with AF.
|
31789884 |
2020 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Circulating MANF concentrations were significantly higher in PD patients compared to controls (<i>P</i> < 0.001) and were positively correlated with Beck Depression Inventory (BDI) depression rating.
|
31555085 |
2019 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Circulating MANF concentrations were significantly higher in PD patients compared to controls (<i>P</i> < 0.001) and were positively correlated with Beck Depression Inventory (BDI) depression rating.
|
31555085 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls.
|
28216543 |
2017 |
|
Focal glomerulosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
K201 and MANF could be promising therapies for the treatment of podocyte ER stress-induced NS/FSGS.
|
31235574 |
2019 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure.
|
20970425 |
2011 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure.
|
20970425 |
2011 |
|
Hyperlipoproteinemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
We describe a gel isoelectric focusing procedure for resolving into at least five bands the arginine-rich protein of very-low-density lipoproteins, and use the method in diagnosis of hyperlipoproteinemia type 3.
|
215348 |
1979 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MANF levels were also associated with the status of liver cirrhosis, advanced Tumor-Node-Metastasis (TNM) stage and tumor size.
|
31469428 |
2019 |
|
Multiple Epiphyseal Dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Treatment of MED chondrocytes with exogenous MANF led to a decrease in the cellular levels of BiP (GRP78), confirming MANF's potential to modulate ER stress responses.
|
30543055 |
2019 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We constructed a set of lentiviral vectors that contain or lack the highly conserved final four amino acids of MANF ("RTDL"), which resemble the canonical ER retention signal ("KDEL"), to study MANF regulation in neuroblastoma cells and rat primary cortical neurons.
|
23255601 |
2013 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients were classified into the following groups based on a review of medical records: (1) acute recurrent idiopathic pancreatitis (ARIP) with or without underlying chronic pancreatitis; (2) idiopathic chronic pancreatitis (ICP) without a history of ARP; (3) an unexplained first episode of acute pancreatitis (AP)<35 years of age; and (4) family history of pancreatitis.
|
28440306 |
2017 |