|
Diabetes Mellitus
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Furthermore, increased MANF levels has been detected in the sera of young children with newly diagnosed Type 1 (T1D) diabetes and Type 2 (T2D) diabetic patients.
|
30386256 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We concluded that serum MANF level was higher in patients with newly diagnosed prediabetes and T2DM than in NGT controls.
|
28216543 |
2017 |
|
Esophageal carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues.
|
10767373 |
2000 |
|
Esophageal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues.
|
10767373 |
2000 |
|
Focal glomerulosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
K201 and MANF could be promising therapies for the treatment of podocyte ER stress-induced NS/FSGS.
|
31235574 |
2019 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure.
|
20970425 |
2011 |
|
Hepatitis
|
0.020 |
Biomarker
|
group |
BEFREE |
In conclusion, MANF plays an important role in linking ER stress and liver inflammation by inhibiting the NF-κB/Snail signal pathway in EMT and HCC progression.
|
31469428 |
2019 |
|
Hepatitis
|
0.020 |
AlteredExpression
|
group |
BEFREE |
These results suggested that the AP‑1 complex may be a novel regulator of MANF transcription, which may be involved in liver inflammation and fibrosis.
|
30365109 |
2018 |
|
Hepatitis B
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, MANF was strongly expressed in the liver tissues of patients with hepatitis B virus (HBV) infection, compared with in normal liver tissues from patients with hepatic hemangioma.
|
30365109 |
2018 |
|
Hepatitis B
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B.
|
29649564 |
2018 |
|
Hyperlipoproteinemias
|
0.010 |
Biomarker
|
disease |
BEFREE |
We describe a gel isoelectric focusing procedure for resolving into at least five bands the arginine-rich protein of very-low-density lipoproteins, and use the method in diagnosis of hyperlipoproteinemia type 3.
|
215348 |
1979 |
|
Idiopathic chronic pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pathogenic genetic variants were identified in 58, 63, and 27% of patients with ARIP, an unexplained first episode of AP <35 years of age, and ICP without ARP, respectively.
|
28440306 |
2017 |
|
Inflammatory disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we determined that ER stress inducible protein Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) was up-regulated in autoimmune diseases and inflammatory disease models.
|
25640174 |
2015 |
|
Insulin-Like Growth Factor I Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results show that the mere IGF-1 deficiency seems to be responsible for an altered expression of genes coding for neurotrophic factors (particularly ciliary neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor), their receptors and signaling pathways (specially RET).
|
30708048 |
2019 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings provide insight into the mechanisms of MANF in promoting functional recovery from ischemic stroke.
|
31785307 |
2020 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
In addition, for the first time, we have discovered that MANF can potentially serve as a urinary ER stress biomarker in ER stress-mediated kidney disease.
|
28719799 |
2017 |
|
Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Recently, we have identified mesencephalic astrocyte-derived neurotrophic factor (MANF) and cysteine-rich with EGF-like domains 2 (CRELD2) as urinary ER stress biomarkers in ER stress-mediated kidney diseases.
|
30099615 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition.
|
31469428 |
2019 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we found that MANF mRNA and protein levels were lower in HCC tissues versus adjacent non-cancer tissues.
|
31469428 |
2019 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MANF levels were also associated with the status of liver cirrhosis, advanced Tumor-Node-Metastasis (TNM) stage and tumor size.
|
31469428 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression of glucocorticoid receptor isoforms and associations with serine/arginine-rich protein 30c and 40 in patients with systemic lupus erythematosus.
|
25665148 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the patients with SLE disease activity index (SLEDAI) <12, PERK and MANF expressions were significantly decreased, compared with the patients with severe SLE (SLEDAI ≥ 12).
|
25226532 |
2014 |
|
Malignant neoplasm of esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To examine the involvement of the ARP gene in esophageal cancer, we screened mutations around codon 50 in 35 ESC tumours and matched normal tissues.
|
10767373 |
2000 |
|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition.
|
31469428 |
2019 |
|
Malignant neoplasm of pancreas
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC).
|
17072959 |
2006 |