ZNF750, zinc finger protein 750, 79755

N. diseases: 20; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1853258
Disease: Seborrhea-Like Dermatitis with Psoriasiform Elements
Seborrhea-Like Dermatitis with Psoriasiform Elements 		0.600 Biomarker disease CTD_human
CUI: C0036508
Disease: Seborrheic dermatitis
Seborrheic dermatitis 		0.100 Biomarker disease HPO
CUI: C0870082
Disease: Hyperkeratosis
Hyperkeratosis 		0.100 Biomarker disease HPO
CUI: C4553962
Disease: Hyperkeratosis, CTCAE
Hyperkeratosis, CTCAE 		0.100 Biomarker phenotype HPO
CUI: C1853258
Disease: Seborrhea-Like Dermatitis with Psoriasiform Elements
Seborrhea-Like Dermatitis with Psoriasiform Elements 		0.600 GermlineCausalMutation disease ORPHANET Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. 16751772 2006
CUI: C1853258
Disease: Seborrhea-Like Dermatitis with Psoriasiform Elements
Seborrhea-Like Dermatitis with Psoriasiform Elements 		0.600 Biomarker disease GENOMICS_ENGLAND Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. 16751772 2006
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 GeneticVariation disease BEFREE This report suggests that ZNF750 mutations could contribute to psoriasis susceptibility. 18256691 2008
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 GeneticVariation disease LHGDN This report suggests that ZNF750 mutations could contribute to psoriasis susceptibility. 18256691 2008
CUI: C1853258
Disease: Seborrhea-Like Dermatitis with Psoriasiform Elements
Seborrhea-Like Dermatitis with Psoriasiform Elements 		0.600 Biomarker disease GENOMICS_ENGLAND Association analysis identifies ZNF750 regulatory variants in psoriasis. 22185198 2011
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 AlteredExpression disease BEFREE Using a promoter functional assay in stimulated human primary keratinocytes, we showed that four ZNF750 promoter and 5' UTR variants displayed a 35-55% reduction of ZNF750 promoter activity, consistent with the promoter activity reduction seen in a Mendelian psoriasis family with a ZNF750 promoter variant. 22185198 2011
CUI: C0262985
Disease: Psoriasiform eczema
Psoriasiform eczema 		0.010 GeneticVariation disease BEFREE Mutations in the ZNF750 promoter and coding regions have been previously associated with Mendelian forms of psoriasis and psoriasiform dermatitis. 22185198 2011
CUI: C0406709
Disease: Hay-Wells syndrome
Hay-Wells syndrome 		0.010 Biomarker disease BEFREE Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63. 22922031 2012
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.030 GeneticVariation disease BEFREE We assessed the association of psoriasis and its main clinical phenotypes with common variants of three potential psoriasis susceptibility genes: ZNF750, RPTOR and TRAF31P2. 24005976 2014
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.060 Biomarker disease BEFREE Functional analyses suggest roles for several genes (CBX4, CBX8, AJUBA, and ZNF750) in ESCC. 25839328 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.010 GeneticVariation disease BEFREE To the best of our knowledge, our study is the first one that links TBCD and ZNF750 mutations to SCZ susceptibility and to the transcript levels in human brain tissues. 26728569 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. 27819679 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE Overexpression of tumor suppressor gene ZNF750 inhibits oral squamous cell carcinoma metastasis. 29113187 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE ZNF750, an epidermal differentiation regulator, has been suggested to act as a tumor suppressor of esophageal squamous cell carcinoma (ESCC). 28558382 2017
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.060 AlteredExpression disease BEFREE The aim of the present study was to evaluate the relationship between ZNF750 expression and response to CRT in ESCC. 28558382 2017
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.060 Biomarker disease BEFREE The present authors previously identified a novel candidate tumor suppressor gene, zinc finger protein 750 (<i>ZNF750</i>), in esophageal squamous cell carcinoma (ESCC) (1). 28789412 2017
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.060 GeneticVariation disease BEFREE Combined analysis from current and previous genomic ESCC studies indicated more frequent ZNF750 mutation in diagnosed cases with LN metastasis than in those without metastasis (14% versus 3.4%, n = 629, P = 1.78 × 10<sup>-5</sup> ). 28608921 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE Overexpression of tumor suppressor gene ZNF750 inhibits oral squamous cell carcinoma metastasis. 29113187 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. 27819679 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 GeneticVariation group BEFREE The Cancer Genome Atlas data further showed that ZNF750 genetic alterations were associated with early disease relapse. 28608921 2017
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 GeneticVariation group BEFREE The Cancer Genome Atlas data further showed that ZNF750 genetic alterations were associated with early disease relapse. 28608921 2017